Polycystin-1 but not polycystin-2 deficiency causes upregulation of the mTOR pathway and can be synergistically targeted with rapamycin and metformin.
about
Vasopressin and disruption of calcium signalling in polycystic kidney disease.Metformin Inhibits Cyst Formation in a Zebrafish Model of Polycystin-2 Deficiency.Double inhibition of cAMP and mTOR signalling may potentiate the reduction of cell growth in ADPKD cells.Activation of Calcium-Sensing Receptor increases intracellular calcium and decreases cAMP and mTOR in PKD1 deficient cells.
P2860
Polycystin-1 but not polycystin-2 deficiency causes upregulation of the mTOR pathway and can be synergistically targeted with rapamycin and metformin.
description
2013 nî lūn-bûn
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2013年の論文
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2013年学术文章
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2013年学术文章
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2013年学术文章
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2013年学术文章
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2013年学术文章
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2013年學術文章
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2013年學術文章
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2013年學術文章
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name
Polycystin-1 but not polycysti ...... with rapamycin and metformin.
@en
Polycystin-1 but not polycysti ...... with rapamycin and metformin.
@nl
type
label
Polycystin-1 but not polycysti ...... with rapamycin and metformin.
@en
Polycystin-1 but not polycysti ...... with rapamycin and metformin.
@nl
prefLabel
Polycystin-1 but not polycysti ...... with rapamycin and metformin.
@en
Polycystin-1 but not polycysti ...... with rapamycin and metformin.
@nl
P2093
P2860
P1433
P1476
Polycystin-1 but not polycysti ...... with rapamycin and metformin.
@en
P2093
Albert C M Ong
Anniek Corvelyn
Djalila Mekahli
Elena Levtchenko
Eva Sammels
Georges Dechênes
Humbert De Smedt
Jean-Paul Decuypere
Joost Schoeber
Kirsten Welkenhuyzen
P2860
P2888
P304
P356
10.1007/S00424-013-1394-X
P577
2013-11-06T00:00:00Z