Suprainduction of p53 by disruption of 40S and 60S ribosome biogenesis leads to the activation of a novel G2/M checkpoint.
about
The importance of ribosome production, and the 5S RNP-MDM2 pathway, in health and diseasePerturbations at the ribosomal genes loci are at the centre of cellular dysfunction and human diseasep53- and ERK7-dependent ribosome surveillance response regulates Drosophila insulin-like peptide secretionStructure of human MDM2 complexed with RPL11 reveals the molecular basis of p53 activationMutation of the diamond-blackfan anemia gene Rps7 in mouse results in morphological and neuroanatomical phenotypesRole of ribosomal protein mutations in tumor development (Review)Inhibition of RNA polymerase I transcription initiation by CX-5461 activates non-canonical ATM/ATR signalingThe 5S RNP couples p53 homeostasis to ribosome biogenesis and nucleolar stressNucleolar stress induces ubiquitination-independent proteasomal degradation of PICT1 proteinDef defines a conserved nucleolar pathway that leads p53 to proteasome-independent degradationMutation of a Nopp140 gene dao-5 alters rDNA transcription and increases germ cell apoptosis in C. elegans.p53 is positively regulated by miR-542-3p.The role of the DNA damage response in zebrafish and cellular models of Diamond Blackfan anemia.The pre-rRNA processing factor DEF is rate limiting for the pathogenesis of MYCN-driven neuroblastoma.Nucleolar stress with and without p53.The emerging importance of ribosomal dysfunction in the pathogenesis of hematologic disorders.Marrow failure: a window into ribosome biologyRibosomal proteins: functions beyond the ribosomeInvolvement of human ribosomal proteins in nucleolar structure and p53-dependent nucleolar stressThe roles of RRP15 in nucleolar formation, ribosome biogenesis and checkpoint control in human cells.Dysregulation of RNA polymerase I transcription during disease.Ribosomal proteins RPL37, RPS15 and RPS20 regulate the Mdm2-p53-MdmX networkStimulation of mTORC1 with L-leucine rescues defects associated with Roberts syndrome.p53-Independent cell cycle and erythroid differentiation defects in murine embryonic stem cells haploinsufficient for Diamond Blackfan anemia-proteins: RPS19 versus RPL5.Crude Extracts, Flavokawain B and Alpinetin Compounds from the Rhizome of Alpinia mutica Induce Cell Death via UCK2 Enzyme Inhibition and in Turn Reduce 18S rRNA Biosynthesis in HT-29 Cells.Ribosome biogenesis dysfunction leads to p53-mediated apoptosis and goblet cell differentiation of mouse intestinal stem/progenitor cellsEffect of low doses of actinomycin D on neuroblastoma cell linesMutual protection of ribosomal proteins L5 and L11 from degradation is essential for p53 activation upon ribosomal biogenesis stressA liaison between mTOR signaling, ribosome biogenesis and cancerRibosomal and hematopoietic defects in induced pluripotent stem cells derived from Diamond Blackfan anemia patients.Repressed synthesis of ribosomal proteins generates protein-specific cell cycle and morphological phenotypes.Sirtuin 7 plays a role in ribosome biogenesis and protein synthesis.Tissue specific roles for the ribosome biogenesis factor Wdr43 in zebrafish development.Regulation of the HDM2-p53 pathway by ribosomal protein L6 in response to ribosomal stress.5S ribosomal RNA is an essential component of a nascent ribosomal precursor complex that regulates the Hdm2-p53 checkpoint.The Potential of Targeting Ribosome Biogenesis in High-Grade Serous Ovarian Cancer.Targeting the ubiquitin-mediated proteasome degradation of p53 for cancer therapy.Translation factors and ribosomal proteins control tumor onset and progression: how?Ribosomal proteins as novel players in tumorigenesis.Targeting RNA polymerase I to treat MYC-driven cancer.
P2860
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P2860
Suprainduction of p53 by disruption of 40S and 60S ribosome biogenesis leads to the activation of a novel G2/M checkpoint.
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
2012年论文
@zh
2012年论文
@zh-cn
name
Suprainduction of p53 by disru ...... on of a novel G2/M checkpoint.
@en
Suprainduction of p53 by disru ...... on of a novel G2/M checkpoint.
@nl
type
label
Suprainduction of p53 by disru ...... on of a novel G2/M checkpoint.
@en
Suprainduction of p53 by disru ...... on of a novel G2/M checkpoint.
@nl
prefLabel
Suprainduction of p53 by disru ...... on of a novel G2/M checkpoint.
@en
Suprainduction of p53 by disru ...... on of a novel G2/M checkpoint.
@nl
P2093
P2860
P356
P1433
P1476
Suprainduction of p53 by disru ...... ion of a novel G2/M checkpoint
@en
P2093
George Thomas
Stefano Fumagalli
Vasily V Ivanenkov
P2860
P304
P356
10.1101/GAD.189951.112
P50
P577
2012-05-01T00:00:00Z