Smac mimetic sensitizes glioblastoma cells to Temozolomide-induced apoptosis in a RIP1- and NF-κB-dependent manner.
about
The role of NF-κB in the pathogenesis of gliomaSmall-molecule SMAC mimetics as new cancer therapeuticsNETRIN-4 protects glioblastoma cells FROM temozolomide induced senescenceOvercoming chemotherapy drug resistance by targeting inhibitors of apoptosis proteins (IAPs)LCL161 increases paclitaxel-induced apoptosis by degrading cIAP1 and cIAP2 in NSCLC.Capsaicin and dihydrocapsaicin induce apoptosis in human glioma cells via ROS and Ca2+‑mediated mitochondrial pathway.BIRC3 is a novel driver of therapeutic resistance in Glioblastoma.How to target apoptosis signaling pathways for the treatment of pediatric cancersIdentification of non-canonical NF-κB signaling as a critical mediator of Smac mimetic-stimulated migration and invasion of glioblastoma cells.Patient-derived glioblastoma cells show significant heterogeneity in treatment responses to the inhibitor-of-apoptosis-protein antagonist birinapantInhibitor of apoptosis protein expression in glioblastomas and their in vitro and in vivo targeting by SMAC mimetic GDC-0152The LEF1/CYLD axis and cIAPs regulate RIP1 deubiquitination and trigger apoptosis in selenite-treated colorectal cancer cells.Distinctive effects of the cellular inhibitor of apoptosis protein c-IAP2 through stabilization by XIAP in glioblastoma multiforme cells.Differential role of RIP1 in Smac mimetic-mediated chemosensitization of neuroblastoma cells.How to train glioma cells to die: molecular challenges in cell death.Smac mimetic promotes glioblastoma cancer stem-like cell differentiation by activating NF-κB.Identification of RIP1 as a critical mediator of Smac mimetic-mediated sensitization of glioblastoma cells for Drozitumab-induced apoptosis.Identification of IRF1 as critical dual regulator of Smac mimetic-induced apoptosis and inflammatory cytokine response.Identification of DR5 as a critical, NF-κB-regulated mediator of Smac-induced apoptosis.Complex Pathologic Roles of RIPK1 and RIPK3: Moving Beyond Necroptosis.PKC activation sensitizes basal-like breast cancer cell lines to Smac mimetics.Smac Mimetic-Induced Upregulation of CCL2/MCP-1 Triggers Migration and Invasion of Glioblastoma Cells and Influences the Tumor Microenvironment in a Paracrine Manner.Smac mimetic-induced upregulation of interferon-β sensitizes glioblastoma to temozolomide-induced cell death.The Smac Mimetic BV6 Improves NK Cell-Mediated Killing of Rhabdomyosarcoma Cells by Simultaneously Targeting Tumor and Effector Cells.Smac mimetic Birinapant induces apoptosis and enhances TRAIL potency in inflammatory breast cancer cells in an IAP-dependent and TNF-α-independent mechanism.Targeting inhibitor of apoptosis proteins by Smac mimetic elicits cell death in poor prognostic subgroups of chronic lymphocytic leukemia.Sensitization of neuroblastoma for vincristine-induced apoptosis by Smac mimetic LCL161 is attended by G2 cell cycle arrest but is independent of NFκB, RIP1 and TNF-α.Apoptotic Signaling Pathways in Glioblastoma and Therapeutic Implications.Glioblastoma and acute myeloid leukemia: malignancies with striking similarities.Inhibitors of apoptosis: clinical implications in cancer.Cell death-based treatment of glioblastoma.Mutagenic assessment of chemotherapy and Smac mimetic drugs in cells with defective DNA damage response pathways
P2860
Q26825502-0705F836-F09C-4777-A210-FAE57827412EQ26864204-2DBD833F-07B1-41E4-9ABA-307422437273Q28535039-3F708602-68F4-430A-8855-A1E405AD4018Q33841579-F904E3F3-8593-4FC8-A6BE-7517CA14B90EQ34542571-74CBF750-C787-43A7-8A3F-1D7777890A91Q36164973-18AA7696-9147-4FF4-AC7C-42E7E584452CQ36591473-56815158-27AD-4A2A-8112-CF930A16B496Q36610528-FF820E1C-4DBF-4E32-B3A4-F7776854D80FQ36738071-FBD4C325-35ED-4A6C-820B-4BCC42F32A9AQ36750717-E1351A19-3BF9-4E0D-BDA4-28FDC9D19DA9Q37412477-15BE14C8-6D7B-4837-8771-0D6AA507BB5CQ37620626-7042255A-101C-4436-A7B1-7C2833AD059BQ37698911-9AA3F758-E6BA-4D93-B9B6-4C1F1091200FQ38310891-A9C2EBF0-DF63-4981-A4DE-8DA4BD087172Q38626416-B6F4A989-0414-4829-8F13-201DC83E3D3AQ38642010-80E216D4-E002-4FFB-B6DC-B652820E019CQ38886482-C88B327C-4FAC-4610-880C-2CC0C4EB250AQ38929174-A04A4A79-9CBE-429B-898C-84AED83DB903Q39052447-ADC0CEF5-A819-4F02-9EFC-D7FF446785D6Q39105381-0E386B4D-BBC4-4B31-954C-8C4406A50F9AQ39463749-FAB4D3B9-A33F-4399-BB26-64F3F07EFA1AQ41977146-192D99F0-D938-4E65-AB88-543DAD3A4020Q42147672-F4C2D726-C489-43F1-8F00-FA8C7CEA27AAQ42317995-3ADB79A5-4E54-4CC8-B2E0-A281944EAC67Q42713862-1FD85E86-8813-4A4D-8AFC-A11CD46FE0ACQ46711978-6DC5E75E-097D-4EA8-81C0-1DD9A5829875Q47107025-28816ED6-0B0E-418E-AD57-8C4F8BDEA6A7Q47136308-A2AC0747-A635-4356-BE77-7944F4B7C4A9Q47339574-B5A3F5F2-B10B-4EF2-869D-3967986546B4Q47607136-343529C0-1A1E-40F3-A680-4B133E91A0BAQ48163001-3BFBA5D5-F94B-4A4A-8864-19F0B0B49286Q58695632-B1CB5D64-FA28-49DD-9380-F6D84875C3B1
P2860
Smac mimetic sensitizes glioblastoma cells to Temozolomide-induced apoptosis in a RIP1- and NF-κB-dependent manner.
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年学术文章
@wuu
2012年学术文章
@zh-cn
2012年学术文章
@zh-hans
2012年学术文章
@zh-my
2012年学术文章
@zh-sg
2012年學術文章
@yue
2012年學術文章
@zh
2012年學術文章
@zh-hant
name
Smac mimetic sensitizes gliobl ...... 1- and NF-κB-dependent manner.
@en
Smac mimetic sensitizes gliobl ...... 1- and NF-κB-dependent manner.
@nl
type
label
Smac mimetic sensitizes gliobl ...... 1- and NF-κB-dependent manner.
@en
Smac mimetic sensitizes gliobl ...... 1- and NF-κB-dependent manner.
@nl
prefLabel
Smac mimetic sensitizes gliobl ...... 1- and NF-κB-dependent manner.
@en
Smac mimetic sensitizes gliobl ...... 1- and NF-κB-dependent manner.
@nl
P2093
P2860
P356
P1433
P1476
Smac mimetic sensitizes gliobl ...... P1- and NF-κB-dependent manner
@en
P2093
K Deshayes
S Cristofanon
V Marschall
P2860
P2888
P304
P356
10.1038/ONC.2012.108
P407
P577
2012-04-02T00:00:00Z