Smac mimetic Birinapant induces apoptosis and enhances TRAIL potency in inflammatory breast cancer cells in an IAP-dependent and TNF-α-independent mechanism.
about
Hepatitis B virus therapy: What's the future holding for us?Small-molecule SMAC mimetics as new cancer therapeuticsTargeting Non-proteolytic Protein Ubiquitination for the Treatment of Diffuse Large B Cell LymphomaChallenging a Misnomer? The Role of Inflammatory Pathways in Inflammatory Breast CancerOvercoming chemotherapy drug resistance by targeting inhibitors of apoptosis proteins (IAPs)Triggering necroptosis in cisplatin and IAP antagonist-resistant ovarian carcinoma.Bortezomib sensitizes non-small cell lung cancer to mesenchymal stromal cell-delivered inducible caspase-9-mediated cytotoxicity.Four genetic polymorphisms of lymphotoxin-alpha gene and cancer risk: a systematic review and meta-analysis.Combination effects of SMAC mimetic birinapant with TNFα, TRAIL, and docetaxel in preclinical models of HNSCC.Apoptotic Effect of Koumine on Human Breast Cancer Cells and the Mechanism Involved.Eliminating hepatitis B by antagonizing cellular inhibitors of apoptosis.Diffusion-weighted MRI for imaging cell death after cytotoxic or apoptosis-inducing therapy.Disulfiram (DSF) acts as a copper ionophore to induce copper-dependent oxidative stress and mediate anti-tumor efficacy in inflammatory breast cancer.An apoptosis-enhancing drug overcomes platinum resistance in a tumour-initiating subpopulation of ovarian cancer.IAP antagonists Birinapant and AT-406 efficiently synergise with either TRAIL, BRAF, or BCL-2 inhibitors to sensitise BRAFV600E colorectal tumour cells to apoptosis.PI3K-independent mTOR activation promotes lapatinib resistance and IAP expression that can be effectively reversed by mTOR and Hsp90 inhibitionMolecular pathways: turning proteasomal protein degradation into a unique treatment approach.Effect of a Smac Mimetic (TL32711, Birinapant) on the Apoptotic Program and Apoptosis Biomarkers Examined with Validated Multiplex Immunoassays Fit for Clinical Use.Smac127 Has Proapoptotic and Anti-Inflammatory Effects on Rheumatoid Arthritis Fibroblast-Like SynoviocytesPatient-derived glioblastoma cells show significant heterogeneity in treatment responses to the inhibitor-of-apoptosis-protein antagonist birinapantX-linked inhibitor of apoptosis protein mediates tumor cell resistance to antibody-dependent cellular cytotoxicity.Imaging caspase-3 activation as a marker of apoptosis-targeted treatment response in cancer.IAP proteins as targets for drug development in oncologyIAP antagonists sensitize murine osteosarcoma cells to killing by TNFαReactivation of Smac-mediated apoptosis in chronic lymphocytic leukemia cells: mechanistic studies of Smac mimetic.Anti-cancer IAP antagonists promote bone metastasis: a cautionary tale.Small molecule inhibitor of apoptosis proteins antagonists: a patent review.Bisphenol A activates EGFR and ERK promoting proliferation, tumor spheroid formation and resistance to EGFR pathway inhibition in estrogen receptor-negative inflammatory breast cancer cells.SMAC Mimetic Birinapant plus Radiation Eradicates Human Head and Neck Cancers with Genomic Amplifications of Cell Death Genes FADD and BIRC2.Three-dimensional culture systems in cancer research: Focus on tumor spheroid model.Discovery of Novel, Potent, and Specific Cell-Death Inducers in the Jurkat Acute Lymphoblastic Leukemia Cell Line.Identification of DR5 as a critical, NF-κB-regulated mediator of Smac-induced apoptosis.The novel SMAC mimetic birinapant exhibits potent activity against human melanoma cells.PKC activation sensitizes basal-like breast cancer cell lines to Smac mimetics.Acute Sensitivity of Ph-like Acute Lymphoblastic Leukemia to the SMAC-Mimetic Birinapant.Differential response of head and neck cancer cell lines to TRAIL or Smac mimetics is associated with the cellular levels and activity of caspase-8 and caspase-10CLL cells are resistant to smac mimetics because of an inability to form a ripoptosome complex.Scientific Summary from the Morgan Welch MD Anderson Cancer Center Inflammatory Breast Cancer (IBC) Program 10th Anniversary Conference.Development of a quantitative pharmacodynamic assay for apoptosis in fixed tumor tissue and its application in distinguishing cytotoxic drug-induced DNA double strand breaks from DNA double strand breaks associated with apoptosis.Simulating and predicting cellular and in vivo responses of colon cancer to combined treatment with chemotherapy and IAP antagonist Birinapant/TL32711.
P2860
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P2860
Smac mimetic Birinapant induces apoptosis and enhances TRAIL potency in inflammatory breast cancer cells in an IAP-dependent and TNF-α-independent mechanism.
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年学术文章
@wuu
2012年学术文章
@zh-cn
2012年学术文章
@zh-hans
2012年学术文章
@zh-my
2012年学术文章
@zh-sg
2012年學術文章
@yue
2012年學術文章
@zh
2012年學術文章
@zh-hant
name
Smac mimetic Birinapant induce ...... d TNF-α-independent mechanism.
@en
Smac mimetic Birinapant induce ...... d TNF-α-independent mechanism.
@nl
type
label
Smac mimetic Birinapant induce ...... d TNF-α-independent mechanism.
@en
Smac mimetic Birinapant induce ...... d TNF-α-independent mechanism.
@nl
prefLabel
Smac mimetic Birinapant induce ...... d TNF-α-independent mechanism.
@en
Smac mimetic Birinapant induce ...... d TNF-α-independent mechanism.
@nl
P2093
P2860
P921
P1476
Smac mimetic Birinapant induce ...... nd TNF-α-independent mechanism
@en
P2093
Gayathri R Devi
Jennifer L Allensworth
Michael A Morse
Scott J Sauer
P2860
P2888
P304
P356
10.1007/S10549-012-2352-6
P407
P577
2012-12-07T00:00:00Z
P6179
1036863515