The deubiquitination enzyme USP46 functions as a tumor suppressor by controlling PHLPP-dependent attenuation of Akt signaling in colon cancer.
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DUBs, New Members in the Hypoxia Signaling clUbThe role of deubiquitinating enzymes in synaptic function and nervous system diseasesDeubiquitinating enzymes as oncotargetsWD repeat protein WDR48 in complex with deubiquitinase USP12 suppresses Akt-dependent cell survival signaling by stabilizing PH domain leucine-rich repeat protein phosphatase 1 (PHLPP1)Allosteric Activation of Ubiquitin-Specific Proteases by β-Propeller Proteins UAF1 and WDR20Behavioral characteristics of ubiquitin-specific peptidase 46-deficient miceThe EBNA3 family of Epstein-Barr virus nuclear proteins associates with the USP46/USP12 deubiquitination complexes to regulate lymphoblastoid cell line growthE1-mediated recruitment of a UAF1-USP deubiquitinase complex facilitates human papillomavirus DNA replicationOTUB1 promotes metastasis and serves as a marker of poor prognosis in colorectal cancer.Aberrant expression of PHLPP1 and PHLPP2 correlates with poor prognosis in patients with hypopharyngeal squamous cell carcinomaArtificial Recruitment of UAF1-USP Complexes by a PHLPP1-E1 Chimeric Helicase Enhances Human Papillomavirus DNA Replication.High PHLPP expression is associated with better prognosis in patients with resected lung adenocarcinomaPHLPP2 Downregulation Contributes to Lung Carcinogenesis Following B[a]P/B[a]PDE ExposureLower expression of PH domain leucine-rich repeat protein phosphatase 1 (PHLPP1) association with poor prognosis of gastric cancerIdentification of candidate genes for familial early-onset essential tremor.The WD40-repeat proteins WDR-20 and WDR-48 bind and activate the deubiquitinating enzyme USP-46 to promote the abundance of the glutamate receptor GLR-1 in the ventral nerve cord of Caenorhabditis elegans.miR-542-3p inhibits colorectal cancer cell proliferation, migration and invasion by targeting OTUB1.CD151 in cancer progression and metastasis: a complex scenario.Cell death and deubiquitinases: perspectives in cancer.PHLPP phosphatases as a therapeutic target in insulin resistance-related diseases.USP49 negatively regulates tumorigenesis and chemoresistance through FKBP51-AKT signaling.Downregulation of USP32 inhibits cell proliferation, migration and invasion in human small cell lung cancer.Deubiquitinating enzyme Usp12 regulates the interaction between the androgen receptor and the Akt pathway.PHLPPing through history: a decade in the life of PHLPP phosphatases.Prognostic significance of USP10 as a tumor-associated marker in gastric carcinoma.Downregulation of PHLPP expression contributes to hypoxia-induced resistance to chemotherapy in colon cancer cells.Oncogenic Ras differentially regulates metabolism and anoikis in extracellular matrix-detached cells.Downregulation of WDR20 due to loss of 14q is involved in the malignant transformation of clear cell renal cell carcinoma.Transcription factor C/EBP-β induces tumor-suppressor phosphatase PHLPP2 through repression of the miR-17-92 cluster in differentiating AML cells.A novel USP9X substrate TTK contributes to tumorigenesis in non-small-cell lung cancer.The novel anti-androgen candidate galeterone targets deubiquitinating enzymes, USP12 and USP46, to control prostate cancer growth and survival.
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P2860
The deubiquitination enzyme USP46 functions as a tumor suppressor by controlling PHLPP-dependent attenuation of Akt signaling in colon cancer.
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年学术文章
@wuu
2012年学术文章
@zh-cn
2012年学术文章
@zh-hans
2012年学术文章
@zh-my
2012年学术文章
@zh-sg
2012年學術文章
@yue
2012年學術文章
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2012年學術文章
@zh-hant
name
The deubiquitination enzyme US ...... Akt signaling in colon cancer.
@en
The deubiquitination enzyme US ...... Akt signaling in colon cancer.
@nl
type
label
The deubiquitination enzyme US ...... Akt signaling in colon cancer.
@en
The deubiquitination enzyme US ...... Akt signaling in colon cancer.
@nl
prefLabel
The deubiquitination enzyme US ...... Akt signaling in colon cancer.
@en
The deubiquitination enzyme US ...... Akt signaling in colon cancer.
@nl
P2093
P2860
P356
P1433
P1476
The deubiquitination enzyme US ...... Akt signaling in colon cancer.
@en
P2093
P D Stevens
P2860
P2888
P304
P356
10.1038/ONC.2012.66
P407
P577
2012-03-05T00:00:00Z
P5875
P6179
1053619176