The phosphatase PHLPP controls the cellular levels of protein kinase C
about
PHLPP-mediated dephosphorylation of S6K1 inhibits protein translation and cell growthScribble-mediated membrane targeting of PHLPP1 is required for its negative regulation of AktPHLiPPing the switch on Akt and protein kinase C signalingRegulation of protein kinase C inactivation by Fas-associated protein with death domainLoss of PHLPP expression in colon cancer: role in proliferation and tumorigenesisDepletion of Pleckstrin homology domain leucine-rich repeat protein phosphatases 1 and 2 by Bcr-Abl promotes chronic myelogenous leukemia cell proliferation through continuous phosphorylation of Akt isoformsTurning off AKT: PHLPP as a drug targetThe Novel PKCθ from Benchtop to ClinicProtein kinase C mechanisms that contribute to cardiac remodellingProtein kinase C: poised to signalSuppression of survival signalling pathways by the phosphatase PHLPPNFκB1 (p50) suppresses SOD2 expression by inhibiting FoxO3a transactivation in a miR190/PHLPP1/Akt-dependent axisThe pursuit of oncotargets through understanding defective cell regulationProtein phosphatase PHLPP1 controls the light-induced resetting of the circadian clockPHLPP1 splice variants differentially regulate AKT and PKCα signaling in hippocampal neurons: characterization of PHLPP proteins in the adult hippocampusPhysiological regulation of Akt activity and stability.Discovery of small molecule inhibitors of the PH domain leucine-rich repeat protein phosphatase (PHLPP) by chemical and virtual screening.Biochemical characterization of the phosphatase domain of the tumor suppressor PH domain leucine-rich repeat protein phosphatase.Pleckstrin homology domain leucine-rich repeat protein phosphatases set the amplitude of receptor tyrosine kinase output.Lysosomal mTORC2/PHLPP1/Akt Regulate Chaperone-Mediated AutophagyDNA damage signaling guards against perturbation of cyclin D1 expression triggered by low-dose long-term fractionated radiationThe synthetic bryostatin analog Merle 23 dissects distinct mechanisms of bryostatin activity in the LNCaP human prostate cancer cell linePhysiological activation of Akt by PHLPP1 deletion protects against pathological hypertrophyMislocalization of the E3 ligase, β-transducin repeat-containing protein 1 (β-TrCP1), in glioblastoma uncouples negative feedback between the pleckstrin homology domain leucine-rich repeat protein phosphatase 1 (PHLPP1) and Akt.Frontier of epilepsy research - mTOR signaling pathway.Regulation of basal lateral membrane mobility and permeability to divalent cations by membrane associated-protein kinase CComplex regulation of PKCβ2 and PDK-1/AKT by ROCK2 in diabetic heart.Aberrant expression of PHLPP1 and PHLPP2 correlates with poor prognosis in patients with hypopharyngeal squamous cell carcinomaIdentification of PHLPP1 as a tumor suppressor reveals the role of feedback activation in PTEN-mutant prostate cancer progression.Active site inhibitors protect protein kinase C from dephosphorylation and stabilize its mature form.Disruption of the interface between the pleckstrin homology (PH) and kinase domains of Akt protein is sufficient for hydrophobic motif site phosphorylation in the absence of mTORC2Pleckstrin homology domain leucine-rich repeat protein phosphatase (PHLPP): a new player in cell signaling.Deletion of the PH-domain and Leucine-rich Repeat Protein Phosphatase 1 (Phlpp1) Increases Fibroblast Growth Factor (Fgf) 18 Expression and Promotes Chondrocyte Proliferation.Peptidyl-prolyl isomerase Pin1 controls down-regulation of conventional protein kinase C isozymesThe phosphatase PHLPP1 regulates Akt2, promotes pancreatic cancer cell death, and inhibits tumor formation.PHLPP2 Downregulation Contributes to Lung Carcinogenesis Following B[a]P/B[a]PDE ExposureLower expression of PH domain leucine-rich repeat protein phosphatase 1 (PHLPP1) association with poor prognosis of gastric cancerDiacylglycerol kinase δ modulates Akt phosphorylation through pleckstrin homology domain leucine-rich repeat protein phosphatase 2 (PHLPP2)Mitochondrial reactive oxygen species perturb AKT/cyclin D1 cell cycle signaling via oxidative inactivation of PP2A in lowdose irradiated human fibroblasts.Agonist-induced down-regulation of endogenous protein kinase c α through an endolysosomal mechanism.
P2860
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P2860
The phosphatase PHLPP controls the cellular levels of protein kinase C
description
2008 nî lūn-bûn
@nan
2008 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի մարտին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
The phosphatase PHLPP controls the cellular levels of protein kinase C
@ast
The phosphatase PHLPP controls the cellular levels of protein kinase C
@en
The phosphatase PHLPP controls the cellular levels of protein kinase C
@en-gb
The phosphatase PHLPP controls the cellular levels of protein kinase C
@nl
type
label
The phosphatase PHLPP controls the cellular levels of protein kinase C
@ast
The phosphatase PHLPP controls the cellular levels of protein kinase C
@en
The phosphatase PHLPP controls the cellular levels of protein kinase C
@en-gb
The phosphatase PHLPP controls the cellular levels of protein kinase C
@nl
prefLabel
The phosphatase PHLPP controls the cellular levels of protein kinase C
@ast
The phosphatase PHLPP controls the cellular levels of protein kinase C
@en
The phosphatase PHLPP controls the cellular levels of protein kinase C
@en-gb
The phosphatase PHLPP controls the cellular levels of protein kinase C
@nl
P2860
P356
P1476
The phosphatase PHLPP controls the cellular levels of protein kinase C
@en
P2093
John Brognard
Tianyan Gao
P2860
P304
P356
10.1074/JBC.M707319200
P407
P577
2008-03-07T00:00:00Z