Proteasome inhibitor MG132 induces selective apoptosis in glioblastoma cells through inhibition of PI3K/Akt and NFkappaB pathways, mitochondrial dysfunction, and activation of p38-JNK1/2 signaling.
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The 26S proteasome is a multifaceted target for anti-cancer therapiesCentral nervous system toxicity of metallic nanoparticlesLoss of SH3GL2 promotes the migration and invasion behaviours of glioblastoma cells through activating the STAT3/MMP2 signalling.Glioma-derived cancer stem cells are hypersensitive to proteasomal inhibition.The oxidation of HSP70 is associated with functional impairment and lack of stimulatory capacityPID1 increases chemotherapy-induced apoptosis in medulloblastoma and glioblastoma cells in a manner that involves NFκB.Enhanced anti-colorectal cancer effects of carfilzomib combined with CPT-11 via downregulation of nuclear factor-κB in vitro and in vivo.Divergent tissue and sex effects of rapamycin on the proteasome-chaperone network of old mice.Hepatitis C Virus Nonstructural Protein 5A Inhibits MG132-Induced Apoptosis of Hepatocytes in Line with NF-κB-Nuclear TranslocationPossible Involvement of Hepatitis B Virus Infection of Hepatocytes in the Attenuation of Apoptosis in Hepatic Stellate CellsProteasome inhibitor MG132 induces NAG-1/GDF15 expression through the p38 MAPK pathway in glioblastoma cellsPrion-mediated neurodegeneration is associated with early impairment of the ubiquitin-proteasome systemPreventive and therapeutic effects of MG132 by activating Nrf2-ARE signaling pathway on oxidative stress-induced cardiovascular and renal injuryGiant axonal neuropathy-associated gigaxonin mutations impair intermediate filament protein degradation.Impact of high glucose and proteasome inhibitor MG132 on histone H2A and H2B ubiquitination in rat glomerular mesangial cells.NFκB is a central regulator of protein quality control in response to protein aggregation stresses via autophagy modulation.Radiosensitization of noradrenaline transporter-expressing tumour cells by proteasome inhibitors and the role of reactive oxygen speciesNEAT1 long noncoding RNA regulates transcription via protein sequestration within subnuclear bodiesSensitization of U937 leukemia cells to doxorubicin by the MG132 proteasome inhibitor induces an increase in apoptosis by suppressing NF-kappa B and mitochondrial membrane potential loss.Mechanisms of proteasome inhibitor-induced cytotoxicity in malignant glioma.A Central Role for Phosphorylated p38α in Linking Proteasome Inhibition-Induced Apoptosis and Autophagy.p62/SQSTM1 is involved in caspase-8 associated cell death induced by proteasome inhibitor MG132 in U87MG cells.MG132-mediated inhibition of the ubiquitin-proteasome pathway ameliorates cancer cachexia.Towards Targeting PI3K-Dependent Regulation of Gene Expression in Brain CancerEffects of proteasome inhibitor MG-132 on the parasite Schistosoma mansoni.Role of SIRT1/PGC-1α in mitochondrial oxidative stress in autistic spectrum disorder.Celastrol inhibits migration and invasion through blocking the NF-κB pathway in ovarian cancer cells.Informed walks: whispering hints to gene hunters inside networks' jungleCystine uptake through the cystine/glutamate antiporter xCT triggers glioblastoma cell death under glucose deprivation.Proteasome inhibitors against amelanotic melanoma.Evaluation of Skin Fibroblasts from Amyotrophic Lateral Sclerosis Patients for the Rapid Study of Pathological Features.Proteasome Inhibitor Carbobenzoxy-L-Leucyl-L-Leucyl-L-Leucinal (MG132) Enhances Therapeutic Effect of Paclitaxel on Breast Cancer by Inhibiting Nuclear Factor (NF)-κB Signaling.Cytocidal effects of arenobufagin and hellebrigenin, two active bufadienolide compounds, against human glioblastoma cell line U-87
P2860
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P2860
Proteasome inhibitor MG132 induces selective apoptosis in glioblastoma cells through inhibition of PI3K/Akt and NFkappaB pathways, mitochondrial dysfunction, and activation of p38-JNK1/2 signaling.
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年学术文章
@wuu
2012年学术文章
@zh-cn
2012年学术文章
@zh-hans
2012年学术文章
@zh-my
2012年学术文章
@zh-sg
2012年學術文章
@yue
2012年學術文章
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2012年學術文章
@zh-hant
name
Proteasome inhibitor MG132 ind ...... ation of p38-JNK1/2 signaling.
@en
Proteasome inhibitor MG132 ind ...... ation of p38-JNK1/2 signaling.
@nl
type
label
Proteasome inhibitor MG132 ind ...... ation of p38-JNK1/2 signaling.
@en
Proteasome inhibitor MG132 ind ...... ation of p38-JNK1/2 signaling.
@nl
prefLabel
Proteasome inhibitor MG132 ind ...... ation of p38-JNK1/2 signaling.
@en
Proteasome inhibitor MG132 ind ...... ation of p38-JNK1/2 signaling.
@nl
P2093
P2860
P1476
Proteasome inhibitor MG132 ind ...... vation of p38-JNK1/2 signaling
@en
P2093
Ana Maria Oliveira Battastini
Elizandra Braganhol
José Cláudio Fonseca Moreira
P2860
P2888
P304
P356
10.1007/S10637-012-9804-Z
P577
2012-02-28T00:00:00Z