Mer receptor tyrosine kinase inhibition impedes glioblastoma multiforme migration and alters cellular morphology
about
Inhibition of MerTK increases chemosensitivity and decreases oncogenic potential in T-cell acute lymphoblastic leukemiaTargeting the TAM Receptors in LeukemiaMERTK receptor tyrosine kinase is a therapeutic target in melanoma.Gefitinib selectively inhibits tumor cell migration in EGFR-amplified human glioblastomaUNC1062, a new and potent Mer inhibitor.TAM receptor tyrosine kinases: expression, disease and oncogenesis in the central nervous system.UNC2025, a potent and orally bioavailable MER/FLT3 dual inhibitor.Prolonged exposure to a Mer ligand in leukemia: Gas6 favors expression of a partial Mer glycoform and reveals a novel role for Mer in the nucleus.Glioblastoma multiforme - an overview.Mer590, a novel monoclonal antibody targeting MER receptor tyrosine kinase, decreases colony formation and increases chemosensitivity in non-small cell lung cancerIncreased expression of MERTK is associated with a unique form of canine retinopathyMertk deficiency affects macrophage directional migration via disruption of cytoskeletal organization.Mer receptor tyrosine kinase is frequently overexpressed in human non-small cell lung cancer, confirming resistance to erlotinib.Mer or Axl receptor tyrosine kinase inhibition promotes apoptosis, blocks growth and enhances chemosensitivity of human non-small cell lung cancerMERTK as a novel therapeutic target in head and neck cancer.Aberrant Mer receptor tyrosine kinase expression contributes to leukemogenesis in acute myeloid leukemia.Small Molecule Inhibition of MERTK Is Efficacious in Non-Small Cell Lung Cancer Models Independent of Driver Oncogene Status.Axl and Mer Receptor Tyrosine Kinases: Distinct and Nonoverlapping Roles in Inflammation and Cancer?MerTK inhibition is a novel therapeutic approach for glioblastoma multiforme.TAM receptor tyrosine kinases as emerging targets of innate immune checkpoint blockade for cancer therapy.Autocrine and paracrine loops between cancer cells and macrophages promote lymph node metastasis via CCR4/CCL22 in head and neck squamous cell carcinoma.Small molecule inhibition of Axl receptor tyrosine kinase potently suppresses multiple malignant properties of glioma cells.MerTK inhibition by RXDX-106 in MerTK activated gastric cancer cell lines.Signaling pathways and mesenchymal transition in pediatric high-grade glioma.The proto-oncogene Mer tyrosine kinase is a novel therapeutic target in mantle cell lymphoma.The role of TAM family receptors and ligands in the nervous system: From development to pathobiology.Trends in Malignant Glioma Monoclonal Antibody Therapy.
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Mer receptor tyrosine kinase inhibition impedes glioblastoma multiforme migration and alters cellular morphology
description
2011 nî lūn-bûn
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2011年の論文
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2011年学术文章
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2011年学术文章
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2011年学术文章
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2011年学术文章
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2011年学术文章
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name
Mer receptor tyrosine kinase i ...... and alters cellular morphology
@en
Mer receptor tyrosine kinase i ...... nd alters cellular morphology.
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type
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Mer receptor tyrosine kinase i ...... and alters cellular morphology
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Mer receptor tyrosine kinase i ...... nd alters cellular morphology.
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Mer receptor tyrosine kinase i ...... and alters cellular morphology
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Mer receptor tyrosine kinase i ...... nd alters cellular morphology.
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Mer receptor tyrosine kinase i ...... and alters cellular morphology
@en
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A E J Rogers
A K Keating
A M Pierce
D K Graham
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P2888
P304
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10.1038/ONC.2011.588
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P577
2011-12-19T00:00:00Z
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1017947886