PARP-3 is a mono-ADP-ribosylase that activates PARP-1 in the absence of DNA
about
Spermatid head elongation with normal nuclear shaping requires ADP-ribosyltransferase PARP11 (ARTD11) in micePoly(ADP-ribose) polymerase 3 (PARP3), a newcomer in cellular response to DNA damage and mitotic progressionReaders of poly(ADP-ribose): designed to be fit for purposeIntracellular Mono-ADP-Ribosylation in Signaling and DiseasePARPs and the DNA damage responseA key role for poly(ADP-ribose) polymerase 3 in ectodermal specification and neural crest developmentThe role of ADP-ribosylation in regulating DNA interstrand crosslink repairSam68 Is Required for DNA Damage Responses via Regulating Poly(ADP-ribosyl)ationPARP inhibitor treatment in ovarian and breast cancerPARP inhibition: PARP1 and beyondPARP3 is a promoter of chromosomal rearrangements and limits G4 DNA.PARP3 affects the relative contribution of homologous recombination and nonhomologous end-joining pathways.Functional Aspects of PARP1 in DNA Repair and Transcription.Evolutionary history of the poly(ADP-ribose) polymerase gene family in eukaryotes.Family-wide analysis of poly(ADP-ribose) polymerase activityThe role of ADP-ribosylation in regulating DNA double-strand break repairInputs and outputs of poly(ADP-ribosyl)ation: Relevance to oxidative stressPoly(ADP-ribosyl)ation acts in the DNA demethylation of mouse primordial germ cells also with DNA damage-independent roles.Affinity-based assays for the identification and quantitative evaluation of noncovalent poly(ADP-ribose)-binding proteins.New PARP targets for cancer therapyNF-κB transcriptional activation by TNFα requires phospholipase C, extracellular signal-regulated kinase 2 and poly(ADP-ribose) polymerase-1Identification and Functional Characterizations of N-Terminal α-N-Methylation and Phosphorylation of Serine 461 in Human Poly(ADP-ribose) Polymerase 3.Crosstalk between poly(ADP-ribose) polymerase and sirtuin enzymes.A systematic analysis of the PARP protein family identifies new functions critical for cell physiology.Structural Implications for Selective Targeting of PARPs.The Sound of Silence: RNAi in Poly (ADP-Ribose) ResearchPARP Inhibitors in Reproductive System Cancers: Current Use and Developments.Poly(ADP-ribose) polymerase inhibitors as promising cancer therapeutics.The underlying mechanism for the PARP and BRCA synthetic lethality: clearing up the misunderstandings.Functions of the poly(ADP-ribose) polymerase superfamily in plants.Therapeutic intervention by the simultaneous inhibition of DNA repair and type I or type II DNA topoisomerases: one strategy, many outcomes.On PAR with PARP: cellular stress signaling through poly(ADP-ribose) and PARP-1.PARP inhibitors in cancer therapy: an update.Resistance to PARP-Inhibitors in Cancer Therapy.Beyond DNA repair, the immunological role of PARP-1 and its siblings.Drug Monographs: Olaratumab and Rucaparib.The PARP family: insights into functional aspects of poly (ADP-ribose) polymerase-1 in cell growth and survival.The PARP3- and ATM-dependent phosphorylation of APLF facilitates DNA double-strand break repair.Poly (ADP-ribose) polymerase (PARP) is not involved in base excision repair but PARP inhibition traps a single-strand intermediate.Poly(ADP-ribose) regulates post-transcriptional gene regulation in the cytoplasm.
P2860
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P2860
PARP-3 is a mono-ADP-ribosylase that activates PARP-1 in the absence of DNA
description
2010 nî lūn-bûn
@nan
2010年の論文
@ja
2010年学术文章
@wuu
2010年学术文章
@zh-cn
2010年学术文章
@zh-hans
2010年学术文章
@zh-my
2010年学术文章
@zh-sg
2010年學術文章
@yue
2010年學術文章
@zh
2010年學術文章
@zh-hant
name
PARP-3 is a mono-ADP-ribosylase that activates PARP-1 in the absence of DNA
@en
PARP-3 is a mono-ADP-ribosylase that activates PARP-1 in the absence of DNA.
@nl
type
label
PARP-3 is a mono-ADP-ribosylase that activates PARP-1 in the absence of DNA
@en
PARP-3 is a mono-ADP-ribosylase that activates PARP-1 in the absence of DNA.
@nl
prefLabel
PARP-3 is a mono-ADP-ribosylase that activates PARP-1 in the absence of DNA
@en
PARP-3 is a mono-ADP-ribosylase that activates PARP-1 in the absence of DNA.
@nl
P2093
P2860
P50
P356
P1476
PARP-3 is a mono-ADP-ribosylase that activates PARP-1 in the absence of DNA
@en
P2093
Helen E Bryant
Olga Loseva
Tobias Karlberg
P2860
P304
P356
10.1074/JBC.M109.077834
P407
P577
2010-01-11T00:00:00Z