Inhibition of proteasome deubiquitinating activity as a new cancer therapy.
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Proteomic analysis reveals that proteasome subunit beta 6 is involved in hypoxia-induced pulmonary vascular remodeling in ratsDUBbing Cancer: Deubiquitylating Enzymes Involved in Epigenetics, DNA Damage and the Cell Cycle As Therapeutic TargetsDrugging the undruggables: exploring the ubiquitin system for drug developmentThe 26S proteasome is a multifaceted target for anti-cancer therapiesDangER: protein ovERload. Targeting protein degradation to treat myelomaFunctions of the 19S complex in proteasomal degradationDeubiquitinating enzymes as oncotargetsTargeted inhibition of the deubiquitinating enzymes, USP14 and UCHL5, induces proteotoxic stress and apoptosis in Waldenström macroglobulinaemia tumour cellsExpression Atlas of the Deubiquitinating Enzymes in the Adult Mouse Retina, Their Evolutionary Diversification and Phenotypic RolesStabilization of an Unusual Salt Bridge in Ubiquitin by the Extra C-Terminal Domain of the Proteasome-Associated Deubiquitinase UCH37 as a Mechanism of Its Exo SpecificityConformational dynamics control ubiquitin-deubiquitinase interactions and influence in vivo signalingDynamic ubiquitination of the mitogen-activated protein kinase kinase (MAPKK) Ste7 determines mitogen-activated protein kinase (MAPK) specificity.Disassembly of Lys11 and mixed linkage polyubiquitin conjugates provides insights into function of proteasomal deubiquitinases Rpn11 and Ubp6.Inhibition of 19S proteasome-associated deubiquitinases by metal-containing compoundsAutoregulation of the 26S proteasome by in situ ubiquitinationNaturally Occurring Isothiocyanates Exert Anticancer Effects by Inhibiting Deubiquitinating EnzymesPerilous journey: a tour of the ubiquitin-proteasome systemJNK-NQO1 axis drives TAp73-mediated tumor suppression upon oxidative and proteasomal stressA novel small molecule inhibitor of deubiquitylating enzyme USP14 and UCHL5 induces apoptosis in multiple myeloma and overcomes bortezomib resistanceActivity-Based Proteomic Profiling of Deubiquitinating Enzymes in Salmonella-Infected Macrophages Leads to Identification of Putative Function of UCH-L5 in Inflammasome RegulationSynthesis and evaluation of derivatives of the proteasome deubiquitinase inhibitor b-AP15Characterization of the 26S proteasome network in Plasmodium falciparumUbiquitin-specific protease 14 regulates c-Jun N-terminal kinase signaling at the neuromuscular junctionDeubiquitinases Modulate Platelet Proteome Ubiquitination, Aggregation, and Thrombosis.Transcriptional Characterization of Compounds: Lessons Learned from the Public LINCS Data.A novel proteasome inhibitor suppresses tumor growth via targeting both 19S proteasome deubiquitinases and 20S proteolytic peptidases.Platinum-containing compound platinum pyrithione suppresses ovarian tumor proliferation through proteasome inhibitionStructure of the Rpn13-Rpn2 complex provides insights for Rpn13 and Uch37 as anticancer targetsOverexpression of ubiquitin specific peptidase 14 predicts unfavorable prognosis in esophageal squamous cell carcinoma.An optimal ubiquitin-proteasome pathway in the nervous system: the role of deubiquitinating enzymes.Clinically used antirheumatic agent auranofin is a proteasomal deubiquitinase inhibitor and inhibits tumor growthElevation of proteasomal substrate levels sensitizes cells to apoptosis induced by inhibition of proteasomal deubiquitinases.Paradigms of protein degradation by the proteasome.The vasculome of the mouse brain.Induction of tumor cell apoptosis by a proteasome deubiquitinase inhibitor is associated with oxidative stressBetulinic acid selectively increases protein degradation and enhances prostate cancer-specific apoptosis: possible role for inhibition of deubiquitinase activityDiscovery of Sulfonamidebenzamides as Selective Apoptotic CHOP Pathway Activators of the Unfolded Protein Response.Small-molecule RA-9 inhibits proteasome-associated DUBs and ovarian cancer in vitro and in vivo via exacerbating unfolded protein responses.In silico functional analyses and discovery of survival-associated microRNA signatures in pediatric osteosarcoma.Inhibitory effect of b-AP15 on the 20S proteasome
P2860
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P2860
Inhibition of proteasome deubiquitinating activity as a new cancer therapy.
description
2011 nî lūn-bûn
@nan
2011年の論文
@ja
2011年学术文章
@wuu
2011年学术文章
@zh-cn
2011年学术文章
@zh-hans
2011年学术文章
@zh-my
2011年学术文章
@zh-sg
2011年學術文章
@yue
2011年學術文章
@zh
2011年學術文章
@zh-hant
name
Inhibition of proteasome deubiquitinating activity as a new cancer therapy.
@en
Inhibition of proteasome deubiquitinating activity as a new cancer therapy.
@nl
type
label
Inhibition of proteasome deubiquitinating activity as a new cancer therapy.
@en
Inhibition of proteasome deubiquitinating activity as a new cancer therapy.
@nl
prefLabel
Inhibition of proteasome deubiquitinating activity as a new cancer therapy.
@en
Inhibition of proteasome deubiquitinating activity as a new cancer therapy.
@nl
P2093
P50
P356
P1433
P1476
Inhibition of proteasome deubiquitinating activity as a new cancer therapy.
@en
P2093
Kristina Lindsten
Maria Hägg Olofsson
Mårten Fryknäs
Slavica Brnjic
P2888
P304
P356
10.1038/NM.2536
P407
P50
P577
2011-11-06T00:00:00Z