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Processing of pulmonary surfactant protein B by napsin and cathepsin HIdentification of a novel topoisomerase inhibitor effective in cells overexpressing drug efflux transportersTargeted inhibition of the deubiquitinating enzymes, USP14 and UCHL5, induces proteotoxic stress and apoptosis in Waldenström macroglobulinaemia tumour cellsCombining [11C]-AnxA5 PET imaging with serum biomarkers for improved detection in live mice of modest cell death in human solid tumor xenograftsCytokeratin-18 is a useful serum biomarker for early determination of response of breast carcinomas to chemotherapySynthesis and evaluation of derivatives of the proteasome deubiquitinase inhibitor b-AP15Induction of mitochondrial dysfunction as a strategy for targeting tumour cells in metabolically compromised microenvironments.Is translational research compatible with preclinical publication strategies?Label-free detection and dynamic monitoring of drug-induced intracellular vesicle formation enabled using a 2-dimensional matched filter.Induction of the lysosomal apoptosis pathway by inhibitors of the ubiquitin-proteasome system.A novel high-through-put assay for screening of pro-apoptotic drugs.Induction of lysosomal membrane permeabilization by compounds that activate p53-independent apoptosis.Charting calcium-regulated apoptosis pathways using chemical biology: role of calmodulin kinase IIConditional drug screening shows that mitotic inhibitors induce AKT/PKB-insensitive apoptosisPhenotype-based drug screening in primary ovarian carcinoma cultures identifies intracellular iron depletion as a promising strategy for cancer treatment.Identification of agents that induce apoptosis of multicellular tumour spheroids: enrichment for mitotic inhibitors with hydrophobic properties.Novel activity of acriflavine against colorectal cancer tumor cells.Elevation of proteasomal substrate levels sensitizes cells to apoptosis induced by inhibition of proteasomal deubiquitinases.Differentiation between cell death modes using measurements of different soluble forms of extracellular cytokeratin 18.Induction of tumor cell apoptosis by a proteasome deubiquitinase inhibitor is associated with oxidative stressSense and sensibility: the use of cell death biomarker assays in high-throughput anticancer drug screening and monitoring treatment responses.Screening for phenotype selective activity in multidrug resistant cells identifies a novel tubulin active agent insensitive to common forms of cancer drug resistance.Determining tumor apoptosis and necrosis in patient serum using cytokeratin 18 as a biomarker.Proteasome Addiction Defined in Ewing Sarcoma Is Effectively Targeted by a Novel Class of 19S Proteasome InhibitorsLysosomes and endoplasmic reticulum: targets for improved, selective anticancer therapy.Autophagy is a protective mechanism for human melanoma cells under acidic stress.Clinical cancer proteomics: promises and pitfalls.Cytokeratin markers come of age.Mechanisms of action of DNA-damaging anticancer drugs in treatment of carcinomas: is acute apoptosis an "off-target" effect?Utilization of cytokeratin-based biomarkers for pharmacodynamic studies.Serum efficacy biomarkers for oncology.Chemical biology suggests a role for calcium signaling in mediating sustained JNK activation during apoptosis.Proteasome deubiquitinases as novel targets for cancer therapy.Molecular pathways: translational potential of deubiquitinases as drug targets.Deubiquitinase inhibition as a cancer therapeutic strategy.Inhibition of proteasome deubiquitinase activity: a strategy to overcome resistance to conventional proteasome inhibitors?Piperlongumine induces inhibition of the ubiquitin-proteasome system in cancer cells.Inhibition of proteasome deubiquitinating activity as a new cancer therapy.Screening of natural products for therapeutic activity against solid tumors.Calpain-mediated Bid cleavage and calpain-independent Bak modulation: two separate pathways in cisplatin-induced apoptosis.
P50
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P50
description
researcher ORCID ID = 0000-0002-4952-445X
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wetenschapper
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Stig Linder
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Stig Linder
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Stig Linder
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Stig Linder
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Stig Linder
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Stig Linder
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Stig Linder
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Stig Linder
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Stig Linder
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Stig Linder
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Stig Linder
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Stig Linder
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P21
P31
P496
0000-0002-4952-445X