1-Benzyl-3-cetyl-2-methylimidazolium iodide (NH125) induces phosphorylation of eukaryotic elongation factor-2 (eEF2): a cautionary note on the anticancer mechanism of an eEF2 kinase inhibitor.
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Elongation factor-2 phosphorylation in dendrites and the regulation of dendritic mRNA translation in neuronsEukaryotic elongation factor 2 kinase as a drug target in cancer, and in cardiovascular and neurodegenerative diseaseseEF-2 Phosphorylation Down-Regulates P-Glycoprotein Over-Expression in Rat Brain Microvessel Endothelial CellsEukaryotic elongation factor 2 kinase regulates the development of hypertension through oxidative stress-dependent vascular inflammationTargeted silencing of elongation factor 2 kinase suppresses growth and sensitizes tumors to doxorubicin in an orthotopic model of breast cancerHigh-throughput screens for eEF-2 kinase.NH125 reduces the level of CPEB3, an RNA binding protein, to promote synaptic GluA2 expression.A high-throughput screening assay for eukaryotic elongation factor 2 kinase inhibitors.Cancer cell response to anthracyclines effects: mysteries of the hidden proteins associated with these drugsAfferent regulation of chicken auditory brainstem neurons: rapid changes in phosphorylation of elongation factor 2.Investigating the kinetic mechanism of inhibition of elongation factor 2 kinase by NH125: evidence of a common in vitro artifactInvolvement of nucleoside diphosphate kinase b and elongation factor 2 in Leishmania braziliensis antimony resistance phenotypeEukaryotic elongation factor 2 kinase confers tolerance to stress conditions in cancer cells.Elongation factor 2 kinase promotes cell survival by inhibiting protein synthesis without inducing autophagy.Heat shock protein 70 protects cardiomyocytes through suppressing SUMOylation and nucleus translocation of phosphorylated eukaryotic elongation factor 2 during myocardial ischemia and reperfusion.Heat shock protein 70 promotes coxsackievirus B3 translation initiation and elongation via Akt-mTORC1 pathway depending on activation of p70S6K and Cdc2.Integrative bioinformatics and proteomics-based discovery of an eEF2K inhibitor (cefatrizine) with ER stress modulation in breast cancer cells.Molecular Mechanism for the Control of Eukaryotic Elongation Factor 2 Kinase by pH: Role in Cancer Cell Survival.Silencing of EEF2K (eukaryotic elongation factor-2 kinase) reveals AMPK-ULK1-dependent autophagy in colon cancer cells.Eukaryotic elongation factor-2 kinase (eEF2K): a potential therapeutic target in cancer.Using docking and alchemical free energy approach to determine the binding mechanism of eEF2K inhibitors and prioritizing the compound synthesis.Regulated stability of eukaryotic elongation factor 2 kinase requires intrinsic but not ongoing activity.Potentiation of Schaffer-Collateral CA1 Synaptic Transmission by eEF2K and p38 MAPK Mediated Mechanisms.Reversible covalent inhibition of eEF-2K by carbonitriles.eEF2K inhibition blocks Aβ42 neurotoxicity by promoting an NRF2 antioxidant response.Eukaryotic elongation factor 2 kinase mediates monocrotaline-induced pulmonary arterial hypertension via reactive oxygen species-dependent vascular remodeling.Eukaryotic elongation factor 2 kinase upregulates the expression of proteins implicated in cell migration and cancer cell metastasis.Fluoxetine induces autophagic cell death via eEF2K-AMPK-mTOR-ULK complex axis in triple negative breast cancer.A decrease in eukaryotic elongation factor 2 phosphorylation is required for local translation of sensorin and long-term facilitation in Aplysia.MYCN amplified neuroblastoma requires the mRNA translation regulator eEF2 kinase to adapt to nutrient deprivation.A Bivalent Securinine Compound SN3-L6 Induces Neuronal Differentiation via Translational Upregulation of Neurogenic Transcription Factors.1-Benzyl-3-cetyl-2-methylimidazolium Iodide (NH125) Is a Broad-Spectrum Inhibitor of Virus Entry with Lysosomotropic Features.Eukaryotic elongation factor 2 kinase controls proliferation and migration of vascular smooth muscle cells.
P2860
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P2860
1-Benzyl-3-cetyl-2-methylimidazolium iodide (NH125) induces phosphorylation of eukaryotic elongation factor-2 (eEF2): a cautionary note on the anticancer mechanism of an eEF2 kinase inhibitor.
description
2011 nî lūn-bûn
@nan
2011年の論文
@ja
2011年学术文章
@wuu
2011年学术文章
@zh-cn
2011年学术文章
@zh-hans
2011年学术文章
@zh-my
2011年学术文章
@zh-sg
2011年學術文章
@yue
2011年學術文章
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2011年學術文章
@zh-hant
name
1-Benzyl-3-cetyl-2-methylimida ...... m of an eEF2 kinase inhibitor.
@en
1-Benzyl-3-cetyl-2-methylimidazolium iodide
@nl
type
label
1-Benzyl-3-cetyl-2-methylimida ...... m of an eEF2 kinase inhibitor.
@en
1-Benzyl-3-cetyl-2-methylimidazolium iodide
@nl
prefLabel
1-Benzyl-3-cetyl-2-methylimida ...... m of an eEF2 kinase inhibitor.
@en
1-Benzyl-3-cetyl-2-methylimidazolium iodide
@nl
P2093
P2860
P356
P1476
1-Benzyl-3-cetyl-2-methylimida ...... m of an eEF2 kinase inhibitor.
@en
P2093
Eric F Johnson
Jennifer B Donnelly
Keith B Glaser
Mai-Ha Bui
Niru B Soni
Sujatha M Gopalakrishnan
Usha Warrior
Zehan Chen
P2860
P304
43951-43958
P356
10.1074/JBC.M111.301291
P407
P577
2011-10-21T00:00:00Z