MYCN amplified neuroblastoma requires the mRNA translation regulator eEF2 kinase to adapt to nutrient deprivation.

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eEF2K protects MYCN-amplified cells from starvation.Activity of translation regulator eukaryotic elongation factor-2 kinase is increased in Parkinson disease brain and its inhibition reduces alpha synuclein toxicity.

P2860

Q52760378-7527E3E4-23DC-4647-958E-41F0CD6B56F7 Q55496331-C8AA94E8-804F-40A8-9536-23F38425C911

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MYCN amplified neuroblastoma requires the mRNA translation regulator eEF2 kinase to adapt to nutrient deprivation.

Item

http://www.wikidata.org/entity/Q50962833

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2017 nî lūn-bûn

@nan

2017年の論文

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2017年学术文章

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2017年学术文章

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2017年学术文章

@zh-cn

2017年学术文章

@zh-hans

2017年学术文章

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2017年学术文章

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2017年學術文章

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2017年學術文章

@zh-hant

name

MYCN amplified neuroblastoma r ...... adapt to nutrient deprivation.

@en

MYCN amplified neuroblastoma r ...... adapt to nutrient deprivation.

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type

Item

label

MYCN amplified neuroblastoma r ...... adapt to nutrient deprivation.

@en

MYCN amplified neuroblastoma r ...... adapt to nutrient deprivation.

@nl

prefLabel

MYCN amplified neuroblastoma r ...... adapt to nutrient deprivation.

@en

MYCN amplified neuroblastoma r ...... adapt to nutrient deprivation.

@nl

P1476

MYCN amplified neuroblastoma r ...... adapt to nutrient deprivation.

@en

P2093

Alberto Delaidelli

http://www.w3.org/2001/XMLSchema#string

Amal El-Naggar

http://www.w3.org/2001/XMLSchema#string

Brandon Jansonius

http://www.w3.org/2001/XMLSchema#string

Christopher J Carnie

http://www.w3.org/2001/XMLSchema#string

Gabriel Leprivier

http://www.w3.org/2001/XMLSchema#string

Gian Luca Negri

http://www.w3.org/2001/XMLSchema#string

Htoo Zarni Oo

http://www.w3.org/2001/XMLSchema#string

John M Maris

http://www.w3.org/2001/XMLSchema#string

Jonathan K M Lim

http://www.w3.org/2001/XMLSchema#string

Marc Remke

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P2860

Drugging MYCN through an allosteric transition in Aurora kinase A

Identification of a new class of protein kinases represented by eukaryotic elongation factor-2 kinase

Exploitation of the Apoptosis-Primed State of MYCN-Amplified Neuroblastoma to Develop a Potent and Specific Targeted Therapy Combination

c-MYC: more than just a matter of life and death

c-Myc binds to human ribosomal DNA and stimulates transcription of rRNA genes by RNA polymerase I

Outcome prediction in pediatric medulloblastoma based on DNA copy-number aberrations of chromosomes 6q and 17q and the MYC and MYCN loci

Chromosome localization in normal human cells and neuroblastomas of a gene related to c-myc

The eEF2 kinase confers resistance to nutrient deprivation by blocking translation elongation

Phosphorylation of elongation factor 2 by EF-2 kinase affects rate of translation

The Myc transactivation domain promotes global phosphorylation of the RNA polymerase II carboxy-terminal domain independently of direct DNA binding

P2888

cdd.2017.79

P304

1564-1576

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P31

scholarly article

P356

10.1038/CDD.2017.79

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P433

http://www.w3.org/2001/XMLSchema#string

P478

http://www.w3.org/2001/XMLSchema#string

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Asad Jan

Debjit Khan

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2017-06-02T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P698

28574509

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P932

5563988

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MYCN amplified neuroblastoma requires the mRNA translation regulator eEF2 kinase to adapt to nutrient deprivation.

about

P2860

P2860

MYCN amplified neuroblastoma requires the mRNA translation regulator eEF2 kinase to adapt to nutrient deprivation.

description

name

type

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P1433

P1476

P2093

P2860

P2888

P304

P31

P356

P433

P478

P50

P577

P698

P932

P356

P1433

P1476

P2093

P2860

P2888

P304

P31

P356

P433

P478

P50

P577

P698

P932