Increased rates of genomic deletions generated by mutations in the yeast gene encoding DNA polymerase delta or by decreases in the cellular levels of DNA polymerase delta
about
An in-frame deletion at the polymerase active site of POLD1 causes a multisystem disorder with lipodystrophyViable nonsense mutants for the essential gene SUP45 of Saccharomyces cerevisiaeDNA polymerase ε and its roles in genome stabilityDNA polymerase delta in DNA replication and genome maintenanceMismatch repair-independent increase in spontaneous mutagenesis in yeast lacking non-essential subunits of DNA polymerase ε.Pol32, a subunit of Saccharomyces cerevisiae DNA polymerase delta, suppresses genomic deletions and is involved in the mutagenic bypass pathway.Human POLD1 modulates cell cycle progression and DNA damage repairPOLE and POLD1 mutations in 529 kindred with familial colorectal cancer and/or polyposis: review of reported cases and recommendations for genetic testing and surveillanceGermline and somatic polymerase ε and δ mutations define a new class of hypermutated colorectal and endometrial cancersDNA replication fidelity and cancerDistinct function of conserved amino acids in the fingers of Saccharomyces cerevisiae DNA polymerase alpha.Low levels of DNA polymerase alpha induce mitotic and meiotic instability in the ribosomal DNA gene cluster of Saccharomyces cerevisiae.A cancer-associated DNA polymerase delta variant modeled in yeast causes a catastrophic increase in genomic instability.Efficient repair of large DNA loops in Saccharomyces cerevisiaeIsolation and characterization of point mutations in mismatch repair genes that destabilize microsatellites in yeast.The flexible loop of human FEN1 endonuclease is required for flap cleavage during DNA replication and repair.Poly(A)-binding protein acts in translation termination via eukaryotic release factor 3 interaction and does not influence [PSI(+)] propagation.Mechanisms of mutagenesis in vivo due to imbalanced dNTP pools.Regulation of genome stability by TEL1 and MEC1, yeast homologs of the mammalian ATM and ATR genes.Genomic instability induced by mutations in Saccharomyces cerevisiae POL1.Ploidy dictates repair pathway choice under DNA replication stress.Fragile site instability in Saccharomyces cerevisiae causes loss of heterozygosity by mitotic crossovers and break-induced replication.Reciprocal uniparental disomy in yeastMutagenic and recombinagenic responses to defective DNA polymerase delta are facilitated by the Rev1 protein in pol3-t mutants of Saccharomyces cerevisiae.Chronic oxidative DNA damage due to DNA repair defects causes chromosomal instability in Saccharomyces cerevisiae.Palm mutants in DNA polymerases alpha and eta alter DNA replication fidelity and translesion activity.The pol3-t hyperrecombination phenotype and DNA damage-induced recombination in Saccharomyces cerevisiae is RAD50 dependent.Chromosome aberrations resulting from double-strand DNA breaks at a naturally occurring yeast fragile site composed of inverted ty elements are independent of Mre11p and Sae2p.Global analysis of genomic instability caused by DNA replication stress in Saccharomyces cerevisiaeStalled replication forks generate a distinct mutational signature in yeast.Hypermutation signature reveals a slippage and realignment model of translesion synthesis by Rev3 polymerase in cisplatin-treated yeast.Remarkably Long-Tract Gene Conversion Induced by Fragile Site Instability in Saccharomyces cerevisiae.Reconstruction of microsatellite mutation history reveals a strong and consistent deletion bias in invasive clonal snails, Potamopyrgus antipodarum.DNA polymerase proofreading: active site switching catalyzed by the bacteriophage T4 DNA polymerase.Reduced levels of DNA polymerase delta induce chromosome fragile site instability in yeast.Family A and B DNA Polymerases in Cancer: Opportunities for Therapeutic Interventions.
P2860
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P2860
Increased rates of genomic deletions generated by mutations in the yeast gene encoding DNA polymerase delta or by decreases in the cellular levels of DNA polymerase delta
description
2000 nî lūn-bûn
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2000年学术文章
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2000年学术文章
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name
Increased rates of genomic del ...... levels of DNA polymerase delta
@en
Increased rates of genomic del ...... evels of DNA polymerase delta.
@nl
type
label
Increased rates of genomic del ...... levels of DNA polymerase delta
@en
Increased rates of genomic del ...... evels of DNA polymerase delta.
@nl
prefLabel
Increased rates of genomic del ...... levels of DNA polymerase delta
@en
Increased rates of genomic del ...... evels of DNA polymerase delta.
@nl
P2093
P2860
P1476
Increased rates of genomic del ...... levels of DNA polymerase delta
@en
P2093
L Stefanovic
R J Kokoska
P2860
P304
P356
10.1128/MCB.20.20.7490-7504.2000
P407
P577
2000-10-01T00:00:00Z