Withaferin A induces apoptosis in human melanoma cells through generation of reactive oxygen species and down-regulation of Bcl-2.
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Upsides and downsides of reactive oxygen species for cancer: the roles of reactive oxygen species in tumorigenesis, prevention, and therapyWithaferin-A--A Natural Anticancer Agent with Pleitropic Mechanisms of ActionWithania somnifera root extract inhibits mammary cancer metastasis and epithelial to mesenchymal transitionDifferential activities of the two closely related withanolides, Withaferin A and Withanone: bioinformatics and experimental evidencesGolden berry-derived 4β-hydroxywithanolide E for selectively killing oral cancer cells by generating ROS, DNA damage, and apoptotic pathwaysWithaferin a alone and in combination with cisplatin suppresses growth and metastasis of ovarian cancer by targeting putative cancer stem cellsIn vitro propagation and withaferin A production in Withania ashwagandha, a rare medicinal plant of IndiaWithaferin A synergizes the therapeutic effect of doxorubicin through ROS-mediated autophagy in ovarian cancerWithaferin A Inhibits STAT3 and Induces Tumor Cell Death in Neuroblastoma and Multiple MyelomaAutophagy: In the cROSshairs of cancer.Oxidative cytotoxic agent withaferin A resensitizes temozolomide-resistant glioblastomas via MGMT depletion and induces apoptosis through Akt/mTOR pathway inhibitory modulation.Withaferin A Induces Cell Death Selectively in Androgen-Independent Prostate Cancer Cells but Not in Normal Fibroblast Cells.Using the heat-shock response to discover anticancer compounds that target protein homeostasis.Synergistic cytotoxic action of cisplatin and withaferin A on ovarian cancer cell lines.Withaferin A causes activation of Notch2 and Notch4 in human breast cancer cellsWithanolide E sensitizes renal carcinoma cells to TRAIL-induced apoptosis by increasing cFLIP degradation.Withaferin A-induced apoptosis in human breast cancer cells is associated with suppression of inhibitor of apoptosis family protein expressionCytotoxicity of withaferin A in glioblastomas involves induction of an oxidative stress-mediated heat shock response while altering Akt/mTOR and MAPK signaling pathways.Withania somnifera Induces Cytotoxic and Cytostatic Effects on Human T Leukemia Cells.Withania somnifera: From prevention to treatment of cancerAutophagy fails to alter withaferin A-mediated lethality in human breast cancer cells.Role of mitogen-activated protein kinases and Mcl-1 in apoptosis induction by withaferin A in human breast cancer cells.Molecular targets and mechanisms of cancer prevention and treatment by withaferin a, a naturally occurring steroidal lactone.Anticancer steroids: linking natural and semi-synthetic compounds.Bioengineering of plant (tri)terpenoids: from metabolic engineering of plants to synthetic biology in vivo and in vitro.Review of natural compounds for potential skin cancer treatment.Pharmacologic overview of Withania somnifera, the Indian Ginseng.WITHAFERIN A INDUCES APOPTOSIS IN RAT C6 GLIOMA CELLS THROUGH REGULATING NF-KB NUCLEAR TRANSLOCATION AND ACTIVATION OF CASPASE CASCADE.Chemistry of withaferin-A: chemo, regio, and stereoselective synthesis of novel spiro-pyrrolizidino-oxindole adducts of withaferin-A via one-pot three-component [3+2] azomethine ylide cycloaddition and their cytotoxicity evaluation.Mitochondrial dysfunction in cancer chemoprevention by phytochemicals from dietary and medicinal plants.Myeloid-derived suppressor cell function is reduced by Withaferin A, a potent and abundant component of Withania somnifera root extract.Molecular insights into cancer therapeutic effects of the dietary medicinal phytochemical withaferin A.Withanolides are potent novel targeted therapeutic agents against adrenocortical carcinomas.Spatane diterpinoid from the brown algae, Stoechospermum marginatum induces apoptosis via ROS induced mitochondrial mediated caspase dependent pathway in murine B16F10 melanoma cells.Withaferin A inhibits the proliferation of gastric cancer cells by inducing G2/M cell cycle arrest and apoptosis.Withaferin A Induces Oxidative Stress-Mediated Apoptosis and DNA Damage in Oral Cancer Cells.Alantolactone induces apoptosis in HepG2 cells through GSH depletion, inhibition of STAT3 activation, and mitochondrial dysfunction.Apoptosis induction of colorectal cancer cells HTL-9 in vitro by the transformed products of soybean isoflavones by Ganoderma lucidum.
P2860
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P2860
Withaferin A induces apoptosis in human melanoma cells through generation of reactive oxygen species and down-regulation of Bcl-2.
description
2011 nî lūn-bûn
@nan
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
2011年论文
@zh
2011年论文
@zh-cn
name
Withaferin A induces apoptosis ...... and down-regulation of Bcl-2.
@en
Withaferin A induces apoptosis ...... and down-regulation of Bcl-2.
@nl
type
label
Withaferin A induces apoptosis ...... and down-regulation of Bcl-2.
@en
Withaferin A induces apoptosis ...... and down-regulation of Bcl-2.
@nl
prefLabel
Withaferin A induces apoptosis ...... and down-regulation of Bcl-2.
@en
Withaferin A induces apoptosis ...... and down-regulation of Bcl-2.
@nl
P2093
P2860
P1433
P1476
Withaferin A induces apoptosis ...... and down-regulation of Bcl-2.
@en
P2093
Antoinette Lemoine
Brigitte Debuire
Catherine Brenner
Cecile Martel
Christophe Lemaire
Cindy Gallerne
Davide Degli Esposti
Eleonore Mayola
Lionel Larue
Shazib Pervaiz
P2860
P2888
P304
P356
10.1007/S10495-011-0625-X
P577
2011-10-01T00:00:00Z