Withaferin A induces apoptosis in human melanoma cells through generation of reactive oxygen species and down-regulation of Bcl-2. - Wikidata - wikimedia - TriplyDB

Withaferin A induces apoptosis in human melanoma cells through generation of reactive oxygen species and down-regulation of Bcl-2.

Withaferin A induces apoptosis in human melanoma cells through generation of reactive oxygen species and down-regulation of Bcl-2.

http://www.wikidata.org/entity/Q39516815

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Upsides and downsides of reactive oxygen species for cancer: the roles of reactive oxygen species in tumorigenesis, prevention, and therapy Withaferin-A--A Natural Anticancer Agent with Pleitropic Mechanisms of Action Withania somnifera root extract inhibits mammary cancer metastasis and epithelial to mesenchymal transition Differential activities of the two closely related withanolides, Withaferin A and Withanone: bioinformatics and experimental evidences Golden berry-derived 4β-hydroxywithanolide E for selectively killing oral cancer cells by generating ROS, DNA damage, and apoptotic pathways Withaferin a alone and in combination with cisplatin suppresses growth and metastasis of ovarian cancer by targeting putative cancer stem cells In vitro propagation and withaferin A production in Withania ashwagandha, a rare medicinal plant of India Withaferin A synergizes the therapeutic effect of doxorubicin through ROS-mediated autophagy in ovarian cancer Withaferin A Inhibits STAT3 and Induces Tumor Cell Death in Neuroblastoma and Multiple Myeloma Autophagy: In the cROSshairs of cancer.Oxidative cytotoxic agent withaferin A resensitizes temozolomide-resistant glioblastomas via MGMT depletion and induces apoptosis through Akt/mTOR pathway inhibitory modulation.Withaferin A Induces Cell Death Selectively in Androgen-Independent Prostate Cancer Cells but Not in Normal Fibroblast Cells.Using the heat-shock response to discover anticancer compounds that target protein homeostasis.Synergistic cytotoxic action of cisplatin and withaferin A on ovarian cancer cell lines.Withaferin A causes activation of Notch2 and Notch4 in human breast cancer cells Withanolide E sensitizes renal carcinoma cells to TRAIL-induced apoptosis by increasing cFLIP degradation.Withaferin A-induced apoptosis in human breast cancer cells is associated with suppression of inhibitor of apoptosis family protein expression Cytotoxicity of withaferin A in glioblastomas involves induction of an oxidative stress-mediated heat shock response while altering Akt/mTOR and MAPK signaling pathways.Withania somnifera Induces Cytotoxic and Cytostatic Effects on Human T Leukemia Cells.Withania somnifera: From prevention to treatment of cancer Autophagy fails to alter withaferin A-mediated lethality in human breast cancer cells.Role of mitogen-activated protein kinases and Mcl-1 in apoptosis induction by withaferin A in human breast cancer cells.Molecular targets and mechanisms of cancer prevention and treatment by withaferin a, a naturally occurring steroidal lactone.Anticancer steroids: linking natural and semi-synthetic compounds.Bioengineering of plant (tri)terpenoids: from metabolic engineering of plants to synthetic biology in vivo and in vitro.Review of natural compounds for potential skin cancer treatment.Pharmacologic overview of Withania somnifera, the Indian Ginseng.WITHAFERIN A INDUCES APOPTOSIS IN RAT C6 GLIOMA CELLS THROUGH REGULATING NF-KB NUCLEAR TRANSLOCATION AND ACTIVATION OF CASPASE CASCADE.Chemistry of withaferin-A: chemo, regio, and stereoselective synthesis of novel spiro-pyrrolizidino-oxindole adducts of withaferin-A via one-pot three-component [3+2] azomethine ylide cycloaddition and their cytotoxicity evaluation.Mitochondrial dysfunction in cancer chemoprevention by phytochemicals from dietary and medicinal plants.Myeloid-derived suppressor cell function is reduced by Withaferin A, a potent and abundant component of Withania somnifera root extract.Molecular insights into cancer therapeutic effects of the dietary medicinal phytochemical withaferin A.Withanolides are potent novel targeted therapeutic agents against adrenocortical carcinomas.Spatane diterpinoid from the brown algae, Stoechospermum marginatum induces apoptosis via ROS induced mitochondrial mediated caspase dependent pathway in murine B16F10 melanoma cells.Withaferin A inhibits the proliferation of gastric cancer cells by inducing G2/M cell cycle arrest and apoptosis.Withaferin A Induces Oxidative Stress-Mediated Apoptosis and DNA Damage in Oral Cancer Cells.Alantolactone induces apoptosis in HepG2 cells through GSH depletion, inhibition of STAT3 activation, and mitochondrial dysfunction.Apoptosis induction of colorectal cancer cells HTL-9 in vitro by the transformed products of soybean isoflavones by Ganoderma lucidum.

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P2860

Withaferin A induces apoptosis in human melanoma cells through generation of reactive oxygen species and down-regulation of Bcl-2.

http://www.wikidata.org/entity/Q39516815

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Withaferin A induces apoptosis ...... and down-regulation of Bcl-2.

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Withaferin A induces apoptosis ...... and down-regulation of Bcl-2.

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Withaferin A induces apoptosis ...... and down-regulation of Bcl-2.

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Withaferin A induces apoptosis ...... and down-regulation of Bcl-2.

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Withaferin A induces apoptosis ...... and down-regulation of Bcl-2.

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Withaferin A induces apoptosis ...... and down-regulation of Bcl-2.

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Antoinette Lemoine

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Brigitte Debuire

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P2860

Use of human cancer cell lines mitochondria to explore the mechanisms of BH3 peptides and ABT-737-induced mitochondrial membrane permeabilization

The Hallmarks of Cancer

Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade

Glutathione depletion and disruption of intracellular ionic homeostasis regulate lymphoid cell apoptosis

Classification of cell death: recommendations of the Nomenclature Committee on Cell Death 2009

The NOX family of ROS-generating NADPH oxidases: physiology and pathophysiology

The Bax/Bcl-2 ratio determines the susceptibility of human melanoma cells to CD95/Fas-mediated apoptosis

Endoplasmic reticulum stress induces calcium-dependent permeability transition, mitochondrial outer membrane permeabilization and apoptosis

Reactive oxygen species, cellular redox systems, and apoptosis

Mitochondrial membrane permeabilization in cell death

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