Using the heat-shock response to discover anticancer compounds that target protein homeostasis. - Wikidata - wikimedia - TriplyDB

Using the heat-shock response to discover anticancer compounds that target protein homeostasis.

Using the heat-shock response to discover anticancer compounds that target protein homeostasis.

http://www.wikidata.org/entity/Q35794082

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Pleiotropic role of HSF1 in neoplastic transformation Photothermal therapy of glioblastoma multiforme using multiwalled carbon nanotubes optimized for diffusion in extracellular space Characterization of the biosynthetic genes for 10,11-dehydrocurvularin, a heat shock response-modulating anticancer fungal polyketide from Aspergillus terreus Withaferin A Analogs That Target the AAA+ Chaperone p97.Redox regulation of antioxidants, autophagy, and the response to stress: implications for electrophile therapeutics.Selective inhibition of p97 by chlorinated analogues of dehydrocurvularin In Vitro Anticancer Effect of Gedunin on Human Teratocarcinomal (NTERA-2) Cancer Stem-Like Cells.Diversity-oriented combinatorial biosynthesis of benzenediol lactone scaffolds by subunit shuffling of fungal polyketide synthases.HSF1 drives a transcriptional program distinct from heat shock to support highly malignant human cancers.Withaferin A induces proteasome inhibition, endoplasmic reticulum stress, the heat shock response and acquisition of thermotolerance.Small molecule activators of the heat shock response: chemical properties, molecular targets, and therapeutic promise.Regulation of the mammalian heat shock factor 1.The reprogramming of tumor stroma by HSF1 is a potent enabler of malignancy.Recent advances in natural product discovery.HDAC6-ubiquitin interaction controls the duration of HSF1 activation after heat shock.Oxidative cytotoxic agent withaferin A resensitizes temozolomide-resistant glioblastomas via MGMT depletion and induces apoptosis through Akt/mTOR pathway inhibitory modulation.FBXW7 modulates cellular stress response and metastatic potential through HSF1 post-translational modification.High-throughput screening system for inhibitors of human Heat Shock Factor 2.Heat shock factor 1 induces cancer stem cell phenotype in breast cancer cell lines Geopyxins A-E, ent-kaurane diterpenoids from endolichenic fungal strains Geopyxis aff. majalis and Geopyxis sp. AZ0066: structure-activity relationships of geopyxins and their analogues.Recent progress regarding the bioactivities, biosynthesis and synthesis of naturally occurring resorcinolic macrolides.Loss of tumor suppressor NF1 activates HSF1 to promote carcinogenesis The yeast Hsp70 Ssa1 is a sensor for activation of the heat shock response by thiol-reactive compounds.Rational reprogramming of fungal polyketide first-ring cyclization Cytotoxicity of withaferin A in glioblastomas involves induction of an oxidative stress-mediated heat shock response while altering Akt/mTOR and MAPK signaling pathways.Withania somnifera: From prevention to treatment of cancer Oxaspirol B with p97 Inhibitory Activity and Other Oxaspirols from Lecythophora sp. FL1375 and FL1031, Endolichenic Fungi Inhabiting Parmotrema tinctorum and Cladonia evansii.Thioesterase domains of fungal nonreducing polyketide synthases act as decision gates during combinatorial biosynthesis.Matching the power of high throughput screening to the chemical diversity of natural products The Role of Sulfhydryl Reactivity of Small Molecules for the Activation of the KEAP1/NRF2 Pathway and the Heat Shock Response NF-κB-induced IL-6 ensures STAT3 activation and tumor aggressiveness in glioblastoma Structure-activity relationship (SAR) of withanolides to inhibit Hsp90 for its activity in pancreatic cancer cells.Sulphoxythiocarbamates modify cysteine residues in HSP90 causing degradation of client proteins and inhibition of cancer cell proliferation.Diversity in the origins of proteostasis networks--a driver for protein function in evolution Tight coordination of protein translation and HSF1 activation supports the anabolic malignant state.Nuclear inclusion bodies of mutant and wild-type p53 in cancer: a hallmark of p53 inactivation and proteostasis remodelling by p53 aggregation.Cytotoxic, apoptotic, and sensitization properties of ent-kaurane-type diterpenoids from Croton tonkinensis Gagnep on human liver cancer HepG2 and Hep3b cell lines.Treatment of adult and pediatric high-grade gliomas with Withaferin A: antitumor mechanisms and future perspectives.Chlorinated Dehydrocurvularins and Alterperylenepoxide A from Alternaria sp. AST0039, a Fungal Endophyte of Astragalus lentiginosus.Withaferin A and its potential role in glioblastoma (GBM).

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Using the heat-shock response to discover anticancer compounds that target protein homeostasis.

http://www.wikidata.org/entity/Q35794082

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name

Using the heat-shock response ...... at target protein homeostasis.

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Using the heat-shock response ...... at target protein homeostasis.

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Using the heat-shock response ...... at target protein homeostasis.

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Using the heat-shock response ...... at target protein homeostasis.

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ACS Chemical Biology

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Using the heat-shock response ...... at target protein homeostasis.

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A A Leslie Gunatilaka

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Casey C Perley

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Christine Rooney

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E M Kithsiri Wijeratne

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Hyoungtae Kwon

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Jon Clardy

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Renee Kontnik

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Sandro Santagata

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Santosh Kesari

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Ya-Ming Xu

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P2860

Deoxygedunin, a natural product with potent neurotrophic activity in mice

RETRACTED: Selective killing of cancer cells by a small molecule targeting the stress response to ROS

The tumor inhibitor and antiangiogenic agent withaferin A targets the intermediate filament protein vimentin

Aneuploidy: cells losing their balance

Heat shock factor 1 is a powerful multifaceted modifier of carcinogenesis

Adapting proteostasis for disease intervention

The Connectivity Map: using gene-expression signatures to connect small molecules, genes, and disease

Direct multiplexed measurement of gene expression with color-coded probe pairs

HSP90 and the chaperoning of cancer

Protein-reactive natural products.

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340-349

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scholarly article

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10.1021/CB200353M

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2

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7

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Susan Lindquist

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2011-11-30T00:00:00Z

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51767724

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22050377

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3291478

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