Cell stress induces TDP-43 pathological changes associated with ERK1/2 dysfunction: implications in ALS.
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Converging mechanisms in ALS and FTD: disrupted RNA and protein homeostasisMetabolomics of human brain aging and age-related neurodegenerative diseasesTherapeutic and diagnostic challenges for frontotemporal dementiaALS-associated TDP-43 induces endoplasmic reticulum stress, which drives cytoplasmic TDP-43 accumulation and stress granule formationTDP-43 aggregation in neurodegeneration: are stress granules the key?Kinase Inhibitor Screening Identifies Cyclin-Dependent Kinases and Glycogen Synthase Kinase 3 as Potential Modulators of TDP-43 Cytosolic Accumulation during Cell Stress.The extracellular signal-regulated kinase 1/2 pathway in neurological diseases: A potential therapeutic target (Review).The Hsp70/Hsp90 Chaperone Machinery in Neurodegenerative DiseasesC-Jun N-terminal kinase controls TDP-43 accumulation in stress granules induced by oxidative stressPhosphorylation of hnRNP K by cyclin-dependent kinase 2 controls cytosolic accumulation of TDP-43.RNP2 of RNA recognition motif 1 plays a central role in the aberrant modification of TDP-43.Induction of COX-2-PGE2 synthesis by activation of the MAPK/ERK pathway contributes to neuronal death triggered by TDP-43-depleted microglia.Early and gender-specific differences in spinal cord mitochondrial function and oxidative stress markers in a mouse model of ALSSlow development of ALS-like spinal cord pathology in mutant valosin-containing protein gene knock-in mice.ALS-linked SOD1 in glial cells enhances ß-N-Methylamino L-Alanine (BMAA)-induced toxicity in Drosophila.Dysregulation of iron metabolism in Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis.Increased expression of microRNA-29a in ALS mice: functional analysis of its inhibition.TDP-43 expression influences amyloidβ plaque deposition and tau aggregation.The cleavage pattern of TDP-43 determines its rate of clearance and cytotoxicity.Activation of AMP-activated protein kinase α1 mediates mislocalization of TDP-43 in amyotrophic lateral sclerosis.TDP-43 associates with stalled ribosomes and contributes to cell survival during cellular stress.Energy Homeostasis and Abnormal RNA Metabolism in Amyotrophic Lateral SclerosisSignificance of long chain polyunsaturated fatty acids in human health.The Emerging Role of the Major Histocompatibility Complex Class I in Amyotrophic Lateral Sclerosis.Pathological hydrogen peroxide triggers the fibrillization of wild-type SOD1 via sulfenic acid modification of Cys-111.Defective synthesis and release of astrocytic thrombospondin-1 mediates the neuronal TDP-43 proteinopathy, resulting in defects in neuronal integrity associated with chronic traumatic encephalopathy: in vitro studies.Increased cytoplasmic TDP-43 reduces global protein synthesis by interacting with RACK1 on polyribosomes.Accumulation of the sigma-1 receptor is common to neuronal nuclear inclusions in various neurodegenerative diseases.A single N-terminal phosphomimic disrupts TDP-43 polymerization, phase separation, and RNA splicing.Reduced stress granule formation and cell death in fibroblasts with the A382T mutation of TARDBP gene: evidence for loss of TDP-43 nuclear function.Folliculin, a tumor suppressor associated with Birt-Hogg-Dubé (BHD) syndrome, is a novel modifier of TDP-43 cytoplasmic translocation and aggregation.Amyotrophic Lateral Sclerosis (ALS) and Adenosine Receptors.The D2 Dopamine Receptor Interferes With the Protective Effect of the A2A Adenosine Receptor on TDP-43 Mislocalization in Experimental Models of Motor Neuron Degeneration.Excitatory Dendritic Mitochondrial Calcium Toxicity: Implications for Parkinson's and Other Neurodegenerative Diseases
P2860
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P2860
Cell stress induces TDP-43 pathological changes associated with ERK1/2 dysfunction: implications in ALS.
description
2011 nî lūn-bûn
@nan
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
2011年论文
@zh
2011年论文
@zh-cn
name
Cell stress induces TDP-43 pat ...... function: implications in ALS.
@en
Cell stress induces TDP-43 pat ...... function: implications in ALS.
@nl
type
label
Cell stress induces TDP-43 pat ...... function: implications in ALS.
@en
Cell stress induces TDP-43 pat ...... function: implications in ALS.
@nl
prefLabel
Cell stress induces TDP-43 pat ...... function: implications in ALS.
@en
Cell stress induces TDP-43 pat ...... function: implications in ALS.
@nl
P2093
P2860
P50
P1476
Cell stress induces TDP-43 pat ...... sfunction: implications in ALS
@en
P2093
Ana Belén Granado-Serrano
Daniel Cacabelos
Ekaterina V Ilieva
Isidro Ferrer
Jerònia Lladó
Manuel Portero-Otin
Victòria Ayala
Víctor Caraballo-Miralles
P2860
P2888
P304
P356
10.1007/S00401-011-0850-Y
P577
2011-06-25T00:00:00Z