Intergenic transcription in the human beta-globin gene cluster.
about
Genome annotation of a 1.5 Mb region of human chromosome 6q23 encompassing a quantitative trait locus for fetal hemoglobin expression in adultsConserved CTCF insulator elements flank the mouse and human beta-globin lociRegulated chromatin domain comprising cluster of co-expressed genes in Drosophila melanogaster.The human beta-globin locus control regionAll of the human beta-type globin genes compete for LCR enhancer activity in embryonic erythroid cells of yeast artificial chromosome transgenic miceLong non-coding RNAs transcribed by ERV-9 LTR retrotransposon act in cis to modulate long-range LTR enhancer function.The human beta-globin locus control region can silence as well as activate gene expressionDevelopmental stage differences in chromatin subdomains of the beta-globin locus.Evidence for somatic gene conversion and deletion in bipolar disorder, Crohn's disease, coronary artery disease, hypertension, rheumatoid arthritis, type-1 diabetes, and type-2 diabetes.Cooperative activities of hematopoietic regulators recruit RNA polymerase II to a tissue-specific chromatin domain.Impact of transposable elements on the evolution of mammalian gene regulation.Sequences in the (A)gamma-delta intergenic region are not required for stage-specific regulation of the human beta-globin gene locusFurther understanding of the beta-globin locus regulation at the molecular level: looping or linking models?Human beta-globin locus control region HS5 contains CTCF- and developmental stage-dependent enhancer-blocking activity in erythroid cells.Chromatin looping and eRNA transcription precede the transcriptional activation of gene in the β-globin locus.Functional intergenic transcription: a case study of the X-inactivation centre.Evolution and expression of chimeric POTE-actin genes in the human genomeDistinctive signatures of histone methylation in transcribed coding and noncoding human beta-globin sequencesTranscription-coupled deposition of histone modifications during MHC class II gene activation.Highly restricted localization of RNA polymerase II within a locus control region of a tissue-specific chromatin domain.The locus control region activates serpin gene expression through recruitment of liver-specific transcription factors and RNA polymerase II.Linear distance from the locus control region determines epsilon-globin transcriptional activity.Gene activity in primary T cells infected with HIV89.6: intron retention and induction of genomic repeats.Organizing the genome: enhancers and insulators.Regulation of human fetal hemoglobin: new players, new complexities.Analysis of intergenic transcription in the human IL-4/IL-13 gene clusterTurnover and function of noncoding RNA polymerase II transcripts.Comprehensive identification of genes driven by ERV9-LTRs reveals TNFRSF10B as a re-activatable mediator of testicular cancer cell death.The ERV-9 LTR enhancer is not blocked by the HS5 insulator and synthesizes through the HS5 site non-coding, long RNAs that regulate LTR enhancer function.Long-range chromosomal interactions regulate the timing of the transition between poised and active gene expression.Chromatin remodeling and extragenic transcription at the MHC class II locus control region.Polypyrimidine tract binding protein modulates efficiency of polyadenylation.Formation of an active tissue-specific chromatin domain initiated by epigenetic marking at the embryonic stem cell stage.Dicer-dependent turnover of intergenic transcripts from the human beta-globin gene cluster.Strong polyadenylation and weak pausing combine to cause efficient termination of transcription in the human Ggamma-globin gene.Evidence for a bigenic chromatin subdomain in regulation of the fetal-to-adult hemoglobin switch.HS2 enhancer function is blocked by a transcriptional terminator inserted between the enhancer and the promoter.The degree of enhancer or promoter activity is reflected by the levels and directionality of eRNA transcription.An alternative approach to medical genetics based on modern evolutionary biology. Part 2: retroviral symbiosis.Identification of a novel enhancer/chromatin opening element associated with high-level γ-globin gene expression
P2860
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P2860
Intergenic transcription in the human beta-globin gene cluster.
description
2001 nî lūn-bûn
@nan
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
2001年论文
@zh
2001年论文
@zh-cn
name
Intergenic transcription in the human beta-globin gene cluster.
@en
Intergenic transcription in the human beta-globin gene cluster.
@nl
type
label
Intergenic transcription in the human beta-globin gene cluster.
@en
Intergenic transcription in the human beta-globin gene cluster.
@nl
prefLabel
Intergenic transcription in the human beta-globin gene cluster.
@en
Intergenic transcription in the human beta-globin gene cluster.
@nl
P2093
P2860
P1476
Intergenic transcription in the human beta-globin gene cluster.
@en
P2093
N J Proudfoot
S J Routledge
P2860
P304
P356
10.1128/MCB.21.19.6507-6514.2001
P407
P577
2001-10-01T00:00:00Z