New Topoisomerase I mutations are associated with resistance to camptothecin - Wikidata - wikimedia - TriplyDB

New Topoisomerase I mutations are associated with resistance to camptothecin

New Topoisomerase I mutations are associated with resistance to camptothecin

http://www.wikidata.org/entity/Q39534943

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Pharmacologic resistance in colorectal cancer: a review Binding of an Indenoisoquinoline to the topoisomerase-DNA complex induces reduction of linker mobility and strengthening of protein-DNA interaction Decreased camptothecin sensitivity of the stem-cell-like fraction of Caco2 cells correlates with an altered phosphorylation pattern of topoisomerase I Rottlerin potentiates camptothecin-induced cytotoxicity in human hormone refractory prostate cancers through increased formation and stabilization of topoisomerase I-DNA cleavage complexes in a PKCδ-independent pathway.Characterization of DNA topoisomerase-1 in Spodoptera exigua for toxicity evaluation of camptothecin and hydoxy-camptothecin.DNA topoisomerase I domain interactions impact enzyme activity and sensitivity to camptothecin.FL118, a novel camptothecin derivative, is insensitive to ABCG2 expression and shows improved efficacy in comparison with irinotecan in colon and lung cancer models with ABCG2-induced resistance.Novel glass slide preparation system for single DNA molecules analysis.Characterization of DNA topoisomerase I in three SN-38 resistant human colon cancer cell lines reveals a new pair of resistance-associated mutations Molecular mechanism of the camptothecin resistance of Glu710Gly topoisomerase IB mutant analyzed in vitro and in silico.ABCG2 expression in colorectal adenocarcinomas may predict resistance to irinotecan.Sequence selectivity of the cleavage sites induced by topoisomerase I inhibitors: a molecular dynamics study.Topoisomerase I inhibition in colorectal cancer: biomarkers and therapeutic targets.Prediction of novel target genes and pathways involved in irinotecan-resistant colorectal cancer.Topoisomerases: Resistance versus Sensitivity, How Far We Can Go?Resveratrol metabolites inhibit human metastatic colon cancer cells progression and synergize with chemotherapeutic drugs to induce cell death.An overview of quinoline as a privileged scaffold in cancer drug discovery.Distribution bias and biochemical characterization of TOP1MT single nucleotide variants.Camptothecin (CPT) and its derivatives are known to target topoisomerase I (Top1) as their mechanism of action: did we miss something in CPT analogue molecular targets for treating human disease such as cancer?SN38-PEG-PLGA-verapamil nanoparticles inhibit proliferation and downregulate drug transporter ABCG2 gene expression in colorectal cancer cells.Camptothecin exhibits topoisomerase1-independent KMT1A suppression and myogenic differentiation in alveolar rhabdomyosarcoma cells.Liposomal codelivery of an SN38 prodrug and a survivin siRNA for tumor therapy Rational development of synergistic combinations of chemotherapy and molecular targeted agents for colorectal cancer treatment

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New Topoisomerase I mutations are associated with resistance to camptothecin

http://www.wikidata.org/entity/Q39534943

description

2011 nî lūn-bûn

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2011年の論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年论文

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2011年论文

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2011年论文

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name

New Topoisomerase I mutations are associated with resistance to camptothecin

@en

New Topoisomerase I mutations are associated with resistance to camptothecin.

@nl

type

label

New Topoisomerase I mutations are associated with resistance to camptothecin

@en

New Topoisomerase I mutations are associated with resistance to camptothecin.

@nl

prefLabel

New Topoisomerase I mutations are associated with resistance to camptothecin

@en

New Topoisomerase I mutations are associated with resistance to camptothecin.

@nl

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Molecular Cancer

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New Topoisomerase I mutations are associated with resistance to camptothecin

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Annick Causse

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Arnaud Coquelle

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Céline Auzanneau

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Céline Gongora

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Maguy Del Rio

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Nadia Vezzio-Vie

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Philippe Pourquier

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Sandie Tuduri

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Vincent Denis

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P2860

Cellular roles of dna topoisomerases: a molecular perspective

Nonlinear partial differential equations and applications: The mechanism of topoisomerase I poisoning by a camptothecin analog

Repair of and checkpoint response to topoisomerase I-mediated DNA damage

Structural flexibility in human topoisomerase I revealed in multiple non-isomorphous crystal structures

Single-molecule analysis reveals clustering and epigenetic regulation of replication origins at the yeast rDNA locus

Breast cancer resistance protein directly confers SN-38 resistance of lung cancer cells.

Topoisomerase I suppresses genomic instability by preventing interference between replication and transcription

Colorectal cancer chemotherapy: irinotecan.

Dynamic molecular combing: stretching the whole human genome for high-resolution studies.

The yeast Sgs1 helicase is differentially required for genomic and ribosomal DNA replication.

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