about
RNAi-based screening identifies the Mms22L-Nfkbil2 complex as a novel regulator of DNA replication in human cells.An N-terminal domain of Dbf4p mediates interaction with both origin recognition complex (ORC) and Rad53p and can deregulate late origin firing.Histone H3 lysine 56 acetylation and the response to DNA replication fork damageAn essential role for Orc6 in DNA replication through maintenance of pre-replicative complexesRescuing stalled or damaged replication forksSemi-conservative replication in yeast nuclear extracts requires Dna2 helicase and supercoiled template.Mrc1 and Tof1 promote replication fork progression and recovery independently of Rad53.Rtt101 and Mms1 in budding yeast form a CUL4(DDB1)-like ubiquitin ligase that promotes replication through damaged DNASingle-molecule analysis reveals clustering and epigenetic regulation of replication origins at the yeast rDNA locusDomain within the helicase subunit Mcm4 integrates multiple kinase signals to control DNA replication initiation and fork progression.A DNA repair pathway score predicts survival in human multiple myeloma: the potential for therapeutic strategyCyclin B-cdk1 kinase stimulates ORC- and Cdc6-independent steps of semiconservative plasmid replication in yeast nuclear extracts.Think global, act local--how to regulate S phase from individual replication origins.Topoisomerase I suppresses genomic instability by preventing interference between replication and transcriptionInvolvement of a chromatin remodeling complex in damage tolerance during DNA replicationSAMHD1 is mutated recurrently in chronic lymphocytic leukemia and is involved in response to DNA damage.The causes of replication stress and their consequences on genome stability and cell fate.The histone deacetylases sir2 and rpd3 act on ribosomal DNA to control the replication program in budding yeast.In vitro DNA replication assays in yeast extracts.The yeast Sgs1 helicase is differentially required for genomic and ribosomal DNA replication.A role for the Cdc7 kinase regulatory subunit Dbf4p in the formation of initiation-competent origins of replication.Multiple roles of replication forks in S phase checkpoints: sensors, effectors and targets.ORC and the intra-S-phase checkpoint: a threshold regulates Rad53p activation in S phase.RPA Mediates Recruitment of MRX to Forks and Double-Strand Breaks to Hold Sister Chromatids Together.DNA replication stress response involving PLK1, CDC6, POLQ, RAD51 and CLASPIN upregulation prognoses the outcome of early/mid-stage non-small cell lung cancer patients.Mec1, INO80, and the PAF1 complex cooperate to limit transcription replication conflicts through RNAPII removal during replication stressRECQ helicases are deregulated in hematological malignancies in association with a prognostic valueMaintenance of fork integrity at damaged DNA and natural pause sites.Nucleotide-resolution DNA double-strand break mapping by next-generation sequencing.Short DNA fragments without sequence similarity are initiation sites for replication in the chromosome of the yeast Yarrowia lipolyticaPhosphorylation of CMG helicase and Tof1 is required for programmed fork arrest.Specific function of phosphoinositide 3-kinase beta in the control of DNA replication.New histone supply regulates replication fork speed and PCNA unloading.DNA repair pathways in human multiple myeloma: role in oncogenesis and potential targets for treatment.Cohesin association to replication sites depends on rad50 and promotes fork restartDefining replication origin efficiency using DNA fiber assays.Analysis of DNA replication profiles in budding yeast and mammalian cells using DNA combing.Genetic and epigenetic determinants of DNA replication origins, position and activation.Time to be versatile: regulation of the replication timing program in budding yeast.Monitoring S phase progression globally and locally using BrdU incorporation in TK(+) yeast strains.
P50
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P50
description
hulumtues
@sq
onderzoeker
@nl
researcher
@en
հետազոտող
@hy
name
Philippe Pasero
@ast
Philippe Pasero
@en
Philippe Pasero
@es
Philippe Pasero
@nl
Philippe Pasero
@sl
type
label
Philippe Pasero
@ast
Philippe Pasero
@en
Philippe Pasero
@es
Philippe Pasero
@nl
Philippe Pasero
@sl
prefLabel
Philippe Pasero
@ast
Philippe Pasero
@en
Philippe Pasero
@es
Philippe Pasero
@nl
Philippe Pasero
@sl
P1053
O-2340-2018
P106
P21
P31
P3829
P496
0000-0001-5891-0822
P569
2000-01-01T00:00:00Z