Which animal models should be used in the search for new antiepileptic drugs? A proposal based on experimental and clinical considerations.
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Preclinical antiepileptic actions of selective serotonin reuptake inhibitors--implications for clinical trial designModern antiepileptic drug development has failed to deliver: ways out of the current dilemma.Effects of a benzodiazepine, bretazenil (Ro 16-6028), on rhythmic metrazol EEG activity: comparison with standard anticonvulsantsEffects of the non-NMDA antagonists NBQX and the 2,3-benzodiazepine GYKI 52466 on different seizure types in mice: comparison with diazepam and interactions with flumazenilAnticonvulsant activity of B2, an adenosine analog, on chemical convulsant-induced seizuresNew in vitro phenotypic assay for epilepsy: fluorescent measurement of synchronized neuronal calcium oscillationsThe effect of Zataria multiflora Boiss hydroalcoholic extract and fractions in pentylenetetrazole-induced kindling in miceAnimal models of epilepsy: use and limitations.Epilepsies with partial seizures in childhood.Effect of root-extracts of Ficus benghalensis (Banyan) in memory, anxiety, muscle co-ordination and seizure in animal models.Protective role of Ashwagandharishta and flax seed oil against maximal electroshock induced seizures in albino ratsLacosamide: pharmacology, mechanisms of action and pooled efficacy and safety data in partial-onset seizures.Synthesis and anticonvulsant activities of (R)-N-(4'-substituted)benzyl 2-acetamido-3-methoxypropionamidesMerging the structural motifs of functionalized amino acids and alpha-aminoamides: compounds with significant anticonvulsant activities.Substituted N-(biphenyl-4'-yl)methyl (R)-2-acetamido-3-methoxypropionamides: potent anticonvulsants that affect frequency (use) dependence and slow inactivation of sodium channels.A new potential AED, carisbamate, substantially reduces spontaneous motor seizures in rats with kainate-induced epilepsyClinical significance of animal seizure models and mechanism of action studies of potential antiepileptic drugs.Experimental and clinical evidence for loss of effect (tolerance) during prolonged treatment with antiepileptic drugs.Differential contribution of GABA(A) receptor subtypes to the anticonvulsant efficacy of benzodiazepine site ligands.Animal models of limbic epilepsies: what can they tell us?A Multifaceted GABAA Receptor Modulator: Functional Properties and Mechanism of Action of the Sedative-Hypnotic and Recreational Drug Methaqualone (Quaalude)Emerging drugs for epilepsy.Anticonvulsant effect of Cicer arietinum seed in animal models of epilepsy: introduction of an active molecule with novel chemical structure.Anticonvulsant and related neuropharmacological effects of the whole plant extract of Synedrella nodiflora (L.) Gaertn (Asteraceae)Anticonvulsant effects of iridoid glycosides fraction purified from Feretia apodanthera Del. (Rubiaceae) in experimental mice models of generalized tonic-clonic seizures.Influence of sildenafil on the anticonvulsant action of selected antiepileptic drugs against pentylenetetrazole-induced clonic seizures in mice.Experimental study of neuropharmacological profile of Euphorbia pulcherrima in mice and rats.The new KCNQ2 activator 4-Chlor-N-(6-chlor-pyridin-3-yl)-benzamid displays anticonvulsant potential.Retigabine.The pharmacokinetics of antiepileptic drugs in rats: consequences for maintaining effective drug levels during prolonged drug administration in rat models of epilepsy.Enhancement of inhibitory neurotransmission and inhibition of excitatory mechanisms underlie the anticonvulsant effects of Mallotus oppositifolius.Anticonvulsant and hypnotic effects of amiodarone.Anticonvulsant and anxiolytic activity of the peptide fraction isolated from the venom of the social wasp Polybia paulistaEfficacy and tolerability of pregabalin in partial epilepsy.Experimental models of status epilepticus and neuronal injury for evaluation of therapeutic interventionsNeuronal Injury, Gliosis, and Glial Proliferation in Two Models of Temporal Lobe Epilepsy.Anticonvulsant potential of ethanol extracts and their solvent partitioned fractions from Flemingia strobilifera root.Intraventricular and intracerebral delivery of anti-epileptic drugs in the kindling model.Anticonvulsant, Anxiolytic, and Sedative Activities of Verbena officinalis.Creatine Revealed Anticonvulsant Properties on Chemically and Electrically Induced Seizures in Mice.
P2860
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P2860
Which animal models should be used in the search for new antiepileptic drugs? A proposal based on experimental and clinical considerations.
description
1988 nî lūn-bûn
@nan
1988年の論文
@ja
1988年論文
@yue
1988年論文
@zh-hant
1988年論文
@zh-hk
1988年論文
@zh-mo
1988年論文
@zh-tw
1988年论文
@wuu
1988年论文
@zh
1988年论文
@zh-cn
name
Which animal models should be ...... l and clinical considerations.
@en
Which animal models should be ...... l and clinical considerations.
@nl
type
label
Which animal models should be ...... l and clinical considerations.
@en
Which animal models should be ...... l and clinical considerations.
@nl
prefLabel
Which animal models should be ...... l and clinical considerations.
@en
Which animal models should be ...... l and clinical considerations.
@nl
P1433
P1476
Which animal models should be ...... l and clinical considerations.
@en
P2093
P304
P356
10.1016/0920-1211(88)90054-X
P577
1988-05-01T00:00:00Z