Selective treatment of hypoxic tumor cells in vivo: phosphate pre-prodrugs of nitro analogues of the duocarmycins.
about
Radioactive phosphorylation of alcohols to monitor biocatalytic Diels-Alder reactionsA five-membered lactone prodrug of CBI-based analogs of the duocarmycinsA novel, unusually efficacious duocarmycin carbamate prodrug that releases no residual byproduct.Efficacious cyclic N-acyl O-amino phenol duocarmycin prodrugs.Metal-mediated targeting in the body.Preparation and properties of clickable amino analogues of the duocarmycins: factors that affect the efficiency of their fluorescent labelling of DNA.Pseudomonas aeruginosa NfsB and nitro-CBI-DEI--a promising enzyme/prodrug combination for gene directed enzyme prodrug therapy.Photoactivatable prodrugs of highly potent duocarmycin analogues for a selective cancer therapy.Preparation and antitumour properties of the enantiomers of a hypoxia-selective nitro analogue of the duocarmycins.Observation by NMR of cationic Wheland-like intermediates in the deiodination of protected 1-iodonaphthalene-2,4-diamines in acidic media.Mechanism of action of AminoCBIs: highly reactive but highly cytotoxic analogues of the duocarmycins.The cytotoxicity of duocarmycin analogues is mediated through alkylation of DNA, not aldehyde dehydrogenase 1: a comment.Modification of the duocarmycin pharmacophore enables CYP1A1 targeting for biological activity.
P2860
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P2860
Selective treatment of hypoxic tumor cells in vivo: phosphate pre-prodrugs of nitro analogues of the duocarmycins.
description
2011 nî lūn-bûn
@nan
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
2011年论文
@zh
2011年论文
@zh-cn
name
Selective treatment of hypoxic ...... analogues of the duocarmycins.
@en
Selective treatment of hypoxic ...... analogues of the duocarmycins.
@nl
type
label
Selective treatment of hypoxic ...... analogues of the duocarmycins.
@en
Selective treatment of hypoxic ...... analogues of the duocarmycins.
@nl
prefLabel
Selective treatment of hypoxic ...... analogues of the duocarmycins.
@en
Selective treatment of hypoxic ...... analogues of the duocarmycins.
@nl
P2093
P2860
P356
P1476
Selective treatment of hypoxic ...... analogues of the duocarmycins.
@en
P2093
Amir Ashoorzadeh
Frederik B Pruijn
Graham J Atwell
K Jane Botting
Moana Tercel
Ralph J Stevenson
Shangjin Yang
Sunali Y Mehta
William A Denny
William R Wilson
P2860
P304
P356
10.1002/ANIE.201004456
P407
P577
2011-02-17T00:00:00Z