Phosphorylated ubiquitin chain is the genuine Parkin receptor. - Wikidata - wikimedia - TriplyDB

Phosphorylated ubiquitin chain is the genuine Parkin receptor.

Phosphorylated ubiquitin chain is the genuine Parkin receptor.

http://www.wikidata.org/entity/Q39589823

about

Ubiquitin modifications Myosins, Actin and Autophagy Metabolic regulation of mitochondrial dynamics Ubiquitin phosphorylation in Parkinson's disease: Implications for pathogenesis and treatment Expanding the ubiquitin code through post-translational modification The three 'P's of mitophagy: PARKIN, PINK1, and post-translational modifications LRRK2 at the interface of autophagosomes, endosomes and lysosomes Autophagy in the liver: cell's cannibalism and beyond Probes of ubiquitin E3 ligases enable systematic dissection of parkin activation Structural insights into Parkin substrate lysine targeting from minimal Miro substrates Site-specific Interaction Mapping of Phosphorylated Ubiquitin to Uncover Parkin Activation.Structure-guided mutagenesis reveals a hierarchical mechanism of Parkin activation.The PINK1 p.I368N mutation affects protein stability and ubiquitin kinase activity (Patho-)physiological relevance of PINK1-dependent ubiquitin phosphorylation A Ubl/ubiquitin switch in the activation of Parkin The ubiquitin signal and autophagy: an orchestrated dance leading to mitochondrial degradation Metabolism and the UPR(mt).Autophagy in acute kidney injury The ubiquitin kinase PINK1 recruits autophagy receptors to induce mitophagy.PINK1, Parkin, and Mitochondrial Quality Control: What can we Learn about Parkinson's Disease Pathobiology?Heterozygous PINK1 p.G411S increases risk of Parkinson's disease via a dominant-negative mechanism.Mitochondrial dysfunction and Parkinson disease: a Parkin-AMPK alliance in neuroprotection.Genes associated with Parkinson's disease: regulation of autophagy and beyond.Targeting the Autophagy/Lysosomal Degradation Pathway in Parkinson's Disease.Pro- and Antioxidant Functions of the Peroxisome-Mitochondria Connection and Its Impact on Aging and Disease Hydrophobic Patch of Ubiquitin is Important for its Optimal Activation by Ubiquitin Activating Enzyme E1.Phospho-ubiquitin: upending the PINK-Parkin-ubiquitin cascade Parkin and PINK1 functions in oxidative stress and neurodegeneration.Integration of cellular ubiquitin and membrane traffic systems: focus on deubiquitylases.Post translational modification of Parkin.Mitochondrial Quality Control and Disease: Insights into Ischemia-Reperfusion Injury.Twenty years since the discovery of the parkin gene.Mitochondrial quality control in amyotrophic lateral sclerosis: towards a common pathway?How phosphoubiquitin activates Parkin.Binding to serine 65-phosphorylated ubiquitin primes Parkin for optimal PINK1-dependent phosphorylation and activation.Mechanism of phospho-ubiquitin-induced PARKIN activation.Dual Function of Phosphoubiquitin in E3 Activation of Parkin.Hydrogen Sulphide modulating mitochondrial morphology to promote mitophagy in endothelial cells under high-glucose and high-palmitate.Phospho-ubiquitin-PARK2 complex as a marker for mitophagy defects.Superoxide drives progression of Parkin/PINK1-dependent mitophagy following translocation of Parkin to mitochondria.

P2860

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P2860

Phosphorylated ubiquitin chain is the genuine Parkin receptor.

http://www.wikidata.org/entity/Q39589823

description

2015 nî lūn-bûn

@nan

2015年の論文

@ja

2015年論文

@yue

2015年論文

@zh-hant

2015年論文

@zh-hk

2015年論文

@zh-mo

2015年論文

@zh-tw

2015年论文

@wuu

2015年论文

@zh

2015年论文

@zh-cn

name

Phosphorylated ubiquitin chain is the genuine Parkin receptor.

@en

Phosphorylated ubiquitin chain is the genuine Parkin receptor.

@nl

type

label

Phosphorylated ubiquitin chain is the genuine Parkin receptor.

@en

Phosphorylated ubiquitin chain is the genuine Parkin receptor.

@nl

prefLabel

Phosphorylated ubiquitin chain is the genuine Parkin receptor.

@en

Phosphorylated ubiquitin chain is the genuine Parkin receptor.

@nl

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P356

P1433

Journal of Cell Biology

P1476

Phosphorylated ubiquitin chain is the genuine Parkin receptor

@en

P2093

Fumika Koyano

http://www.w3.org/2001/XMLSchema#string

Hidetaka Kosako

http://www.w3.org/2001/XMLSchema#string

Kei Okatsu

http://www.w3.org/2001/XMLSchema#string

Keiji Tanaka

http://www.w3.org/2001/XMLSchema#string

Mayumi Kimura

http://www.w3.org/2001/XMLSchema#string

Yasushi Saeki

http://www.w3.org/2001/XMLSchema#string

P2860

PINK1 is selectively stabilized on impaired mitochondria to activate Parkin

Parkinson's disease-associated kinase PINK1 regulates Miro protein level and axonal transport of mitochondria

Parkin is activated by PINK1-dependent phosphorylation of ubiquitin at Ser65

Ubiquitin is phosphorylated by PINK1 to activate parkin

PINK1 and Parkin target Miro for phosphorylation and degradation to arrest mitochondrial motility

PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1

The mitochondrial deubiquitinase USP30 opposes parkin-mediated mitophagy

UBCH7 reactivity profile reveals parkin and HHARI to be RING/HECT hybrids

Mitofusin 1 and mitofusin 2 are ubiquitinated in a PINK1/parkin-dependent manner upon induction of mitophagy

p62/SQSTM1 is required for Parkin-induced mitochondrial clustering but not mitophagy; VDAC1 is dispensable for both

P304

111-128

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scholarly article

P356

10.1083/JCB.201410050

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P407

P433

1

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P478

209

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P50

Noriyuki Matsuda

P577

2015-04-06T00:00:00Z

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P5875

274644606

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25847540

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P921

phosphorylation

P932

4395490

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