A single-chain triplebody with specificity for CD19 and CD33 mediates effective lysis of mixed lineage leukemia cells by dual targeting.
about
Catch me if you can: Leukemia Escape after CD19-Directed T Cell ImmunotherapiesAntibody-siRNA conjugates: drugging the undruggable for anti-leukemic therapy.T cell-recruiting triplebody 19-3-19 mediates serial lysis of malignant B-lymphoid cells by a single T cellNK cells from an AML patient have recovered in remission and reached comparable cytolytic activity to that of a healthy monozygotic twin mediated by the single-chain triplebody SPM-2.The biology of NK cells and their receptors affects clinical outcomes after hematopoietic cell transplantation (HCT).A dual-targeting triplebody mediates preferential redirected lysis of antigen double-positive over single-positive leukemic cells.Dual targeting strategies with bispecific antibodies.Multi-specific antibodies for cancer immunotherapy.Update on antigen-specific immunotherapy of acute myeloid leukemia.Mono- and dual-targeting triplebodies activate natural killer cells and have anti-tumor activity in vitro and in vivo against chronic lymphocytic leukemia.Simultaneous targeting of prostate stem cell antigen and prostate-specific membrane antigen improves the killing of prostate cancer cells using a novel modular T cell-retargeting system.Acute myeloid leukemia targets for bispecific antibodies.Antigen Loss Variants: Catching Hold of Escaping Foes.Human glioma-initiating cells show a distinct immature phenotype resembling but not identical to NG2 gliaCD19-specific triplebody SPM-1 engages NK and γδ T cells for rapid and efficient lysis of malignant B-lymphoid cells.A recombinant triplebody with specificity for CD19 and HLA-DR mediates preferential binding to antigen double-positive cells by dual-targeting.Dual-targeting triplebody 33-3-19 mediates selective lysis of biphenotypic CD19+ CD33+ leukemia cells.Triplebody Mediates Increased Anti-Leukemic Reactivity of IL-2 Activated Donor Natural Killer (NK) Cells and Impairs Viability of Their CD33-Expressing NK Subset.Novel multispecific heterodimeric antibody format allowing modular assembly of variable domain fragments.The making of bispecific antibodiesT lymphocytes can be effectively recruited for ex vivo and in vivo lysis of AML blasts by a novel CD33/CD3-bispecific BiTE antibody construct.Generation of BiKEs and TriKEs to Improve NK Cell-Mediated Targeting of Tumor Cells.Natural killer cells unleashed: Checkpoint receptor blockade and BiKE/TriKE utilization in NK-mediated anti-tumor immunotherapy.
P2860
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P2860
A single-chain triplebody with specificity for CD19 and CD33 mediates effective lysis of mixed lineage leukemia cells by dual targeting.
description
2011 nî lūn-bûn
@nan
2011年の論文
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2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
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2011年论文
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2011年论文
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name
A single-chain triplebody with ...... kemia cells by dual targeting.
@en
A single-chain triplebody with ...... kemia cells by dual targeting.
@nl
type
label
A single-chain triplebody with ...... kemia cells by dual targeting.
@en
A single-chain triplebody with ...... kemia cells by dual targeting.
@nl
prefLabel
A single-chain triplebody with ...... kemia cells by dual targeting.
@en
A single-chain triplebody with ...... kemia cells by dual targeting.
@nl
P2093
P2860
P356
P1476
A single-chain triplebody with ...... ukemia cells by dual targeting
@en
P2093
Andreas Mackensen
Bernhard Stockmeyer
Christoph Stein
Domenica Saul
Georg H Fey
Heiko Singer
Ingo Schubert
Kristin Mentz
Markus Kügler
Michael Schwenkert
P2860
P356
10.4161/MABS.3.1.14057
P577
2011-01-01T00:00:00Z