Proteasome inhibitors induce nucleolar aggregation of proteasome target proteins and polyadenylated RNA by altering ubiquitin availability.
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C9ORF72, implicated in amytrophic lateral sclerosis and frontotemporal dementia, regulates endosomal traffickingNucleolar activity in neurodegenerative diseases: a missing piece of the puzzle?Emerging roles of the neuronal nucleolusCRM1 and its ribosome export adaptor NMD3 localize to the nucleolus and affect rRNA synthesis.Small RNA expression and deep sequencing analyses of the nucleolus reveal the presence of nucleolus-associated microRNAs.Bowman-Birk inhibitors from legumes as colorectal chemopreventive agents.An intranucleolar body associated with rDNA.Tumor proteomics by multivariate analysis on individual pathway data for characterization of vulvar cancer phenotypes.Parkinson's disease DJ-1 L166P alters rRNA biogenesis by exclusion of TTRAP from the nucleolus and sequestration into cytoplasmic aggregates via TRAF6How the nucleus copes with proteotoxic stress.Functional ultrastructure of the plant nucleolus.Elucidation of motifs in ribosomal protein S9 that mediate its nucleolar localization and binding to NPM1/nucleophosminNucleocytoplasmic shuttling of valosin-containing protein (VCP/p97) regulated by its N domain and C-terminal region.Proteasome activity influences UV-mediated subnuclear localization changes of NPM.Evidence for ubiquitin-regulated nuclear and subnuclear trafficking among Paramyxovirinae matrix proteinsThe nucleolus directly regulates p53 export and degradationQuantitative proteomics and dynamic imaging of the nucleolus reveal distinct responses to UV and ionizing radiation.Dictyostelium discoideum has a highly Q/N-rich proteome and shows an unusual resilience to protein aggregation.Intracellular transport of recombinant adeno-associated virus vectors.Novel insights into renal D-amino acid oxidase accumulation: propiverine changes DAAO localization and peroxisomal size in vivo.Distribution of dipeptide repeat proteins in cellular models and C9orf72 mutation cases suggests link to transcriptional silencingUnderstanding renal nuclear protein accumulation: an in vitro approach to explain an in vivo phenomenon.SUMO regulates p21Cip1 intracellular distribution and with p21Cip1 facilitates multiprotein complex formation in the nucleolus upon DNA damageHuman cytomegalovirus UL76 elicits novel aggresome formation via interaction with S5a of the ubiquitin proteasome system.Nucleolar Enrichment of Brain Proteins with Critical Roles in Human Neurodevelopment.TP53 supports basal-like differentiation of mammary epithelial cells by preventing translocation of deltaNp63 into nucleoli.Nucleolar aggresomes as counterparts of cytoplasmic aggresomes in proteotoxic stress. Proteasome inhibitors induce nuclear ribonucleoprotein inclusions that accumulate several key factors of neurodegenerative diseases and cancer.Molecular targeted agents for gastric and gastroesophageal junction cancer.Nucleolar control of p53: a cellular Achilles' heel and a target for cancer therapy.Expanding the prion concept to cancer biology: dominant-negative effect of aggregates of mutant p53 tumour suppressorCellular maintenance of nuclear protein homeostasisThe aggregation of mutant p53 produces prion-like properties in cancer.Nucleolar aggresomes mediate release of pericentric heterochromatin and nuclear destruction of genotoxically treated cancer cells.Nuclear inclusion bodies of mutant and wild-type p53 in cancer: a hallmark of p53 inactivation and proteostasis remodelling by p53 aggregation.Protein quality control in the nucleus.The proteasome inhibitor lactacystin exerts its therapeutic effects on glioma via apoptosis: an in vitro and in vivo study.Probing the stiffness of isolated nucleoli by atomic force microscopy.Nucleolar Proteome Analysis and Proteasomal Activity Assays Reveal a Link between Nucleolus and 26S Proteasome in A. thaliana.Nucleoplasmic/nucleolar translocation and identification of a nuclear localization signal (NLS) in Dictyostelium BAF60a/SMARCD1 homologue Snf12.Presence of Not5 and ubiquitinated Rps7A in polysome fractions depends upon the Not4 E3 ligase.
P2860
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P2860
Proteasome inhibitors induce nucleolar aggregation of proteasome target proteins and polyadenylated RNA by altering ubiquitin availability.
description
2010 nî lūn-bûn
@nan
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
2010年论文
@zh
2010年论文
@zh-cn
name
Proteasome inhibitors induce n ...... tering ubiquitin availability.
@en
Proteasome inhibitors induce n ...... tering ubiquitin availability.
@nl
type
label
Proteasome inhibitors induce n ...... tering ubiquitin availability.
@en
Proteasome inhibitors induce n ...... tering ubiquitin availability.
@nl
prefLabel
Proteasome inhibitors induce n ...... tering ubiquitin availability.
@en
Proteasome inhibitors induce n ...... tering ubiquitin availability.
@nl
P2093
P2860
P356
P1433
P1476
Proteasome inhibitors induce n ...... tering ubiquitin availability.
@en
P2093
P2860
P2888
P304
P356
10.1038/ONC.2010.469
P407
P577
2010-10-18T00:00:00Z
P6179
1040206426