Expression of Cdc18/Cdc6 and Cdt1 during G2 phase induces initiation of DNA replication.
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The regulated association of Cdt1 with minichromosome maintenance proteins and Cdc6 in mammalian cellsMCM-BP regulates unloading of the MCM2-7 helicase in late S phaseRegulation of CDC6, geminin, and CDT1 in human cells that undergo polyploidizationGenome-wide mapping of DNA synthesis in Saccharomyces cerevisiae reveals that mechanisms preventing reinitiation of DNA replication are not redundant.Loss of rereplication control in Saccharomyces cerevisiae results in extensive DNA damageDNA damage induces Cdt1 proteolysis in fission yeast through a pathway dependent on Cdt2 and Ddb1Licensing for DNA replication requires a strict sequential assembly of Cdc6 and Cdt1 onto chromatin in Xenopus egg extractsCyclin-dependent kinases phosphorylate human Cdt1 and induce its degradationPCNA is a cofactor for Cdt1 degradation by CUL4/DDB1-mediated N-terminal ubiquitinationCheckpoint effects and telomere amplification during DNA re-replication in fission yeast.Cell and plastid division are coordinated through the prereplication factor AtCDT1Specific replication origins promote DNA amplification in fission yeast.Site-specific ORC binding, pre-replication complex assembly and DNA synthesis at Schizosaccharomyces pombe replication origins.Initiation and termination of DNA replication during S phase in relation to cyclins D1, E and A, p21WAF1, Cdt1 and the p12 subunit of DNA polymerase δ revealed in individual cells by cytometryControl of DNA replication licensing in a cell cycle.Replication licensing--defining the proliferative state?Genome-wide analysis of re-replication reveals inhibitory controls that target multiple stages of replication initiationRB deletion disrupts coordination between DNA replication licensing and mitotic entry in vivo.The CENP-B homolog, Abp1, interacts with the initiation protein Cdc23 (MCM10) and is required for efficient DNA replication in fission yeast.Eukaryotic MCM proteins: beyond replication initiation.Modulation of cell cycle-specific gene expressions at the onset of S phase arrest contributes to the robust DNA replication checkpoint response in fission yeast.CRL4-DDB1-VPRBP ubiquitin ligase mediates the stress triggered proteolysis of Mcm10.Sequential steps in DNA replication are inhibited to ensure reduction of ploidy in meiosis.Repression of nascent strand elongation by deregulated Cdt1 during DNA replication in Xenopus egg extracts.DNA replication licensing control and rereplication prevention.Regulating DNA replication in eukarya.Overexpression of the replication licensing regulators hCdt1 and hCdc6 characterizes a subset of non-small-cell lung carcinomas: synergistic effect with mutant p53 on tumor growth and chromosomal instability--evidence of E2F-1 transcriptional controSwi1 prevents replication fork collapse and controls checkpoint kinase Cds1.Swi1 and Swi3 are components of a replication fork protection complex in fission yeast.Rapid degradation of Cdt1 upon UV-induced DNA damage is mediated by SCFSkp2 complex.The role and regulation of the preRC component Cdc6 in the initiation of premeiotic DNA replication.Cdc18/CDC6 activates the Rad3-dependent checkpoint in the fission yeast.C. elegans CUL-4 prevents rereplication by promoting the nuclear export of CDC-6 via a CKI-1-dependent pathwayCell cycle-regulated gene expression in Arabidopsis.CUL-4 ubiquitin ligase maintains genome stability by restraining DNA-replication licensing.DNA replication licensing affects cell proliferation or endoreplication in a cell type-specific manner.RB loss promotes aberrant ploidy by deregulating levels and activity of DNA replication factors.
P2860
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P2860
Expression of Cdc18/Cdc6 and Cdt1 during G2 phase induces initiation of DNA replication.
description
2001 nî lūn-bûn
@nan
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
2001年论文
@zh
2001年论文
@zh-cn
name
Expression of Cdc18/Cdc6 and Cdt1 during G2 phase induces initiation of DNA replication.
@en
Expression of Cdc18/Cdc6 and Cdt1 during G2 phase induces initiation of DNA replication.
@nl
type
label
Expression of Cdc18/Cdc6 and Cdt1 during G2 phase induces initiation of DNA replication.
@en
Expression of Cdc18/Cdc6 and Cdt1 during G2 phase induces initiation of DNA replication.
@nl
prefLabel
Expression of Cdc18/Cdc6 and Cdt1 during G2 phase induces initiation of DNA replication.
@en
Expression of Cdc18/Cdc6 and Cdt1 during G2 phase induces initiation of DNA replication.
@nl
P2093
P2860
P356
P1433
P1476
Expression of Cdc18/Cdc6 and Cdt1 during G2 phase induces initiation of DNA replication.
@en
P2093
P2860
P304
P356
10.1093/EMBOJ/20.17.4648
P407
P577
2001-09-01T00:00:00Z