Cyclin-dependent kinases phosphorylate human Cdt1 and induce its degradation - Wikidata - wikimedia - TriplyDB

Cyclin-dependent kinases phosphorylate human Cdt1 and induce its degradation

Cyclin-dependent kinases phosphorylate human Cdt1 and induce its degradation

http://www.wikidata.org/entity/Q28248715

about

Cdt1 associates dynamically with chromatin throughout G1 and recruits Geminin onto chromatin Two E3 ubiquitin ligases, SCF-Skp2 and DDB1-Cul4, target human Cdt1 for proteolysis.DTL/CDT2 is essential for both CDT1 regulation and the early G2/M checkpoint Human geminin promotes pre-RC formation and DNA replication by stabilizing CDT1 in mitosis Prevention of DNA re-replication in eukaryotic cells Replication licensing and cancer--a fatal entanglement?Regulation of death-associated protein kinase. Stabilization by HSP90 heterocomplexes Preventing re-replication of chromosomal DNA.DNA damage induces Cdt1 proteolysis in fission yeast through a pathway dependent on Cdt2 and Ddb1 The Non-Canonical Role of Aurora-A in DNA Replication Regulation of Unperturbed DNA Replication by Ubiquitylation Genomic instability in cancer.Cyclin E and Cdk2 control GLD-1, the mitosis/meiosis decision, and germline stem cells in Caenorhabditis elegans Regulation and Function of Cdt1; A Key Factor in Cell Proliferation and Genome Stability Targeting the cyclin-dependent kinases (CDK) 4/6 in estrogen receptor-positive breast cancers Helicase loading at chromosomal origins of replication PCNA is a cofactor for Cdt1 degradation by CUL4/DDB1-mediated N-terminal ubiquitination Cellular checkpoint mechanisms monitoring proper initiation of DNA replication Cyclin D1: polymorphism, aberrant splicing and cancer risk USP37 deubiquitinates Cdt1 and contributes to regulate DNA replication Deregulation of F-box proteins and its consequence on cancer development, progression and metastasis.Stress-stimulated mitogen-activated protein kinases control the stability and activity of the Cdt1 DNA replication licensing factor The APC/C inhibitor, Emi1, is essential for prevention of rereplication Replication-dependent destruction of Cdt1 limits DNA replication to a single round per cell cycle in Xenopus egg extracts.DDB1 maintains genome integrity through regulation of Cdt1 Comparison of gene expression profiles between primary tumor and metastatic lesions in gastric cancer patients using laser microdissection and cDNA microarray.Activation of Cdk2 stimulates proteasome-dependent truncation of tyrosine phosphatase SHP-1 in human proliferating intestinal epithelial cells.Proliferating cell nuclear antigen-dependent rapid recruitment of Cdt1 and CRL4Cdt2 at DNA-damaged sites after UV irradiation in HeLa cells.Ras activity regulates cyclin E degradation by the Fbw7 pathway.CDK phosphorylation of a novel NLS-NES module distributed between two subunits of the Mcm2-7 complex prevents chromosomal rereplication SCF-FBXO31 E3 ligase targets DNA replication factor Cdt1 for proteolysis in the G2 phase of cell cycle to prevent re-replication.Cdt1 is differentially targeted for degradation by anticancer chemotherapeutic drugs.Cell type-dependent requirement for PIP box-regulated Cdt1 destruction during S phase.A novel role of proteasomal β1 subunit in tumorigenesis.Replication licensing and the DNA damage checkpoint.CDK1-dependent inhibition of the E3 ubiquitin ligase CRL4CDT2 ensures robust transition from S Phase to Mitosis.Knockdown of SCF(Skp2) function causes double-parked accumulation in the nucleus and DNA re-replication in Drosophila plasmatocytes.Dynamic loading and redistribution of the Mcm2-7 helicase complex through the cell cycle.Cdt1 revisited: complex and tight regulation during the cell cycle and consequences of deregulation in mammalian cells.Regulation of CDK4

P2860

Q24298173-BD893DBE-AB70-43F3-AEFD-E85C430F0D89 Q24304921-9FB33A9D-C166-4B44-87AE-D990DDD762E6 Q24312094-AC526BF3-B72F-496E-B030-26E06E26C0BC Q24563189-C5396BD8-81E9-44D3-8BF5-55224AAF15D9 Q24632601-7A292BA8-CB00-47A5-9DC2-A06FE5E2AD7A Q24644766-D0709C52-5CAE-4B14-BDA4-C42144943FA0 Q24646541-7BF67943-A4AA-4A5B-A676-8CAEE20AACA6 Q24653685-98EBAA64-0177-420A-8AE8-F69252D2E900 Q24672982-0DC4A7AE-46A3-4AAC-B33D-4E79C4AF97F1 Q26784066-308FEAFC-5818-482C-A114-60FF3F2E2569 Q26853389-1561E2D6-6C34-42D4-BB29-C0CA5E3CD351 Q27013707-29BDA59A-29A6-4F24-AE56-877760768280 Q27342769-AEB1208A-9924-4B61-9A9A-A291548D43A7 Q28068574-873C0DB3-4E7B-4E77-9C66-01A9010000FF Q28069910-F7D33EA0-FD57-4983-ACD3-3EE64C682764 Q28289537-ED806B77-77FA-475B-85CB-6F4A2A289FAD Q28291192-EFEB6FC5-0B51-4551-AA07-AA30FE83C68C Q28297754-2A5A3C10-85E6-4651-B6D1-92CEC4978D68 Q28303053-B77CA205-F5AB-4489-A3B4-58EDAA08660E Q28771759-56252B02-38E7-4FED-B94D-CBEB6C5F77C4 Q30278581-3FE5D3AA-3E32-4765-9867-20CA972829F8 Q30427155-DBAC35A2-4EF3-43C8-976D-0D7E58673503 Q30442630-0CAC6678-ACFD-48E5-8498-AFCCBDD18F7C Q31136186-681B7FD8-B937-439D-8250-1720784B00C2 Q33255742-35589996-3A87-4A1E-A945-ADC225F3CC94 Q33263793-8EB397F3-8CF5-41C1-8130-773B98DAF57F Q33350768-2FE409D8-A8DC-4DBA-9F3E-8DFF121493EE Q33712618-3F611343-985E-4D11-919E-9477B7DFF43D Q33892360-1C34C1A2-CF03-4710-8443-1C30E4610FB0 Q34049869-1D7BC704-CC56-475B-937F-CE2363697C16 Q34073816-684BFC37-A247-4F60-A5CA-CDD05DF07309 Q34222698-5BCBD36E-8C08-4F25-AA43-57AEAEB5381C Q34249169-496A0DF6-75FF-49AC-9E13-79A3C1B5F666 Q34347861-6369DA62-16C5-42DD-943A-F6CD127501C7 Q34547673-A94FA660-645B-471C-AF3A-5D2D47E34F63 Q34801657-8E14970D-8860-4D99-AE45-10F378574BBB Q35036898-306159EB-0BC3-49E2-A248-C5C2B67997D8 Q35090675-47528AEF-96D5-4A71-9DAF-BF846DDEDDC8 Q35107397-6939D58A-05CB-493D-93B3-68AF71E04336 Q35147982-F624EE42-6B52-4B3A-802B-DB92BF06E169

P2860

Cyclin-dependent kinases phosphorylate human Cdt1 and induce its degradation

http://www.wikidata.org/entity/Q28248715

description

2004 թուականի Ապրիլին հրատարակուած գիտական յօդուած

@hyw

2004 թվականի ապրիլին հրատարակված գիտական հոդված

@hy

article publié dans la revue scientifique Journal of Biological Chemistry

@fr

artículu científicu espublizáu en 2004

@ast

im April 2004 veröffentlichter wissenschaftlicher Artikel

@de

scientific article (publication date: 23 April 2004)

@en

vedecký článok (publikovaný 2004/04/23)

@sk

vědecký článek publikovaný v roce 2004

@cs

wetenschappelijk artikel (gepubliceerd op 2004/04/23)

@nl

наукова стаття, опублікована у квітні 2004

@uk

name

Cyclin-dependent kinases phosphorylate human Cdt1 and induce its degradation

@ast

Cyclin-dependent kinases phosphorylate human Cdt1 and induce its degradation

@en

Cyclin-dependent kinases phosphorylate human Cdt1 and induce its degradation

@nl

type

label

Cyclin-dependent kinases phosphorylate human Cdt1 and induce its degradation

@ast

Cyclin-dependent kinases phosphorylate human Cdt1 and induce its degradation

@en

Cyclin-dependent kinases phosphorylate human Cdt1 and induce its degradation

@nl

prefLabel

Cyclin-dependent kinases phosphorylate human Cdt1 and induce its degradation

@ast

Cyclin-dependent kinases phosphorylate human Cdt1 and induce its degradation

@en

Cyclin-dependent kinases phosphorylate human Cdt1 and induce its degradation

@nl

P1433

Q28248715-DD58BEBE-D891-41AB-B20D-B2B513A6D224

P1476

Q28248715-7D5C3DC7-FEBC-44E4-9222-B20C88E6D0BF

P2093

Q28248715-1E5CAB3D-800C-469A-9F8D-FF0A0EA6E2EF

Q28248715-37E9F146-30C5-4DB5-A3B5-B579027E82BC

Q28248715-38463323-9350-476D-B28F-027A1E4114B0

Q28248715-52B02FC6-169D-4BB3-BF40-58EA126F30F4

Q28248715-86D23750-547D-47B5-9823-8F7ACF097139

P2860

Q28248715-036DF2A5-9F61-430A-8C35-139C79FF0121

Q28248715-0A7537E5-2F9F-4D0E-B390-0BCEBF36FE54

Q28248715-0F5C93E9-2446-46F2-BB86-2A7D6575AAB5

Q28248715-17693B71-C18C-4E5C-AC48-FCF4463C11F0

Q28248715-23403D5C-58C8-431D-AD60-3802C5888149

Q28248715-34ED6C02-E2F0-47F3-840A-FE4C2F3FC28B

Q28248715-3995FC59-B3E5-491C-B864-1EC488A2822C

Q28248715-3B31E4DC-1393-4D9D-9313-B8C5836076F2

Q28248715-4135B872-A9F5-4019-8E8B-B14720A3EB74

Q28248715-42AC8CA9-AE60-4A28-A0DD-58110394D4CA

P304

Q28248715-F217B82F-7D53-447D-A4BF-DAB7D2FCAAC7

P31

Q28248715-205D83CF-4868-4DD6-BFC9-7D4CA7BE450A

P356

Q28248715-FA8D8534-4296-43D4-8F1D-BC3FE344BE23

P407

Q28248715-DE340441-4911-4E84-996B-71DA6888A5B1

P433

Q28248715-7B8A5258-949B-4224-B3EC-BFBFE2BD9065

P478

Q28248715-DA78AD26-4C8E-4786-9DB3-6012BED0075E

P577

Q28248715-49B783D4-FFA4-403D-870A-BB53067A72C0

P5875

Q28248715-DFF70A26-4D4B-430F-A2E2-73DEBC2C14D8

P698

Q28248715-57994223-449D-4313-94BB-6E1898D978F9

P921

Q28248715-43C32A41-4E38-4288-BBDB-FFB87776C7CE

P356

P1433

Journal of Biological Chemistry

P1476

Cyclin-dependent kinases phosphorylate human Cdt1 and induce its degradation

@en

P2093

Enbo Liu

http://www.w3.org/2001/XMLSchema#string

Feng Yan

http://www.w3.org/2001/XMLSchema#string

Qiping Zhao

http://www.w3.org/2001/XMLSchema#string

Xianghong Li

http://www.w3.org/2001/XMLSchema#string

Xiaohua Wu

http://www.w3.org/2001/XMLSchema#string

P2860

Inhibition of eukaryotic DNA replication by geminin binding to Cdt1

The Cdc4/34/53 pathway targets Cdc6p for proteolysis in budding yeast

Phosphorylation of mammalian CDC6 by cyclin A/CDK2 regulates its subcellular localization

Multistep regulation of DNA replication by Cdk phosphorylation of HsCdc6

DNA replication in eukaryotic cells

XCDT1 is required for the assembly of pre-replicative complexes in Xenopus laevis

The Cdt1 protein is required to license DNA for replication in fission yeast

The SCF(Skp2) ubiquitin ligase complex interacts with the human replication licensing factor Cdt1 and regulates Cdt1 degradation

The human licensing factor for DNA replication Cdt1 accumulates in G1 and is destabilized after initiation of S-phase

Association of BRCA1 with Rad51 in mitotic and meiotic cells

P304

17283-8

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1074/JBC.C300549200

http://www.w3.org/2001/XMLSchema#string

P407

P433

17

http://www.w3.org/2001/XMLSchema#string

P478

279

http://www.w3.org/2001/XMLSchema#string

P577

2004-04-23T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

8678710

http://www.w3.org/2001/XMLSchema#string

P698

15004027

http://www.w3.org/2001/XMLSchema#string

P921

phosphorylation