From preclinical to human--prediction of oral absorption and drug-drug interaction potential using physiologically based pharmacokinetic (PBPK) modeling approach in an industrial setting: a workflow by using case example.
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Developing a Physiologically-Based Pharmacokinetic Model Knowledgebase in Support of Provisional Model ConstructionA physiologically based pharmacokinetic model of the minipig: data compilation and model implementation.Applications of linking PBPK and PD models to predict the impact of genotypic variability, formulation differences, differences in target binding capacity and target site drug concentrations on drug responses and variabilityPreclinical pharmacokinetics of TPN729MA, a novel PDE5 inhibitor, and prediction of its human pharmacokinetics using a PBPK model.Dose selection based on physiologically based pharmacokinetic (PBPK) approaches.Physiologically based pharmacokinetics joined with in vitro-in vivo extrapolation of ADME: a marriage under the arch of systems pharmacology.Predicting drug-drug interactions: application of physiologically based pharmacokinetic models under a systems biology approach.Utility of models of the gastrointestinal tract for assessment of the digestion and absorption of engineered nanomaterials released from food matrices.Dealing with the complex drug-drug interactions: towards mechanistic models.Physiologically based pharmacokinetic modeling in drug discovery and development: a pharmaceutical industry perspective.A strategy for early-risk predictions of clinical drug-drug interactions involving the GastroPlusTM DDI module for time-dependent CYP inhibitors.Development of a Multicompartment Permeability-Limited Lung PBPK Model and Its Application in Predicting Pulmonary Pharmacokinetics of Antituberculosis Drugs.Applied Concepts in PBPK Modeling: How to Build a PBPK/PD Model.Basic concepts in physiologically based pharmacokinetic modeling in drug discovery and development.Transporter-Enzyme Interplay: Deconvoluting Effects of Hepatic Transporters and Enzymes on Drug Disposition Using Static and Dynamic Mechanistic Models.Hepatic transporter drug-drug interactions: an evaluation of approaches and methodologies.Use of a semi-physiological pharmacokinetic model to investigate the influence of itraconazole on tacrolimus absorption, distribution and metabolism in mice.Absolute Oral Bioavailability of Creatine Monohydrate in Rats: Debunking a Myth.
P2860
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P2860
From preclinical to human--prediction of oral absorption and drug-drug interaction potential using physiologically based pharmacokinetic (PBPK) modeling approach in an industrial setting: a workflow by using case example.
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
2012年论文
@zh
2012年论文
@zh-cn
name
From preclinical to human--pre ...... orkflow by using case example.
@en
From preclinical to human--pre ...... ogically based pharmacokinetic
@nl
type
label
From preclinical to human--pre ...... orkflow by using case example.
@en
From preclinical to human--pre ...... ogically based pharmacokinetic
@nl
prefLabel
From preclinical to human--pre ...... orkflow by using case example.
@en
From preclinical to human--pre ...... ogically based pharmacokinetic
@nl
P2093
P2860
P356
P1476
From preclinical to human--pre ...... orkflow by using case example.
@en
P2093
Achiel Van Peer
Claire Mackie
Donald Heald
Jan Snoeys
Nancy Van Osselaer
Vikash Kumar Sinha
P2860
P304
P356
10.1002/BDD.1782
P577
2012-03-01T00:00:00Z