Crosstalk between the PI3K/mTOR and MEK/ERK pathways involved in the maintenance of self-renewal and tumorigenicity of glioblastoma stem-like cells.
about
PI3K/Akt/mTOR signaling pathway in cancer stem cells: from basic research to clinical applicationCellular microenvironment modulates the galvanotaxis of brain tumor initiating cellsTargeting SOX2 as a Therapeutic Strategy in GlioblastomaOvercoming therapeutic resistance in glioblastoma: the way forwardLack of BRAF-V600E Mutation in Papillary Tumor of the Pineal Region.Small G protein Rac GTPases regulate the maintenance of glioblastoma stem-like cells in vitro and in vivo.HMMR maintains the stemness and tumorigenicity of glioblastoma stem-like cells.Recent advances in the use of PI3K inhibitors for glioblastoma multiforme: current preclinical and clinical developmentRole for putative hepatocellular carcinoma stem cell subpopulations in biological response to incomplete thermal ablation: in vitro and in vivo pilot study.The dual PI3K/mTOR inhibitor NVP-BEZ235 induces tumor regression in a genetically engineered mouse model of PIK3CA wild-type colorectal cancer.Systemic approaches identify a garlic-derived chemical, Z-ajoene, as a glioblastoma multiforme cancer stem cell-specific targeting agent.The anti-hypertensive drug prazosin inhibits glioblastoma growth via the PKCĪ“-dependent inhibition of the AKT pathway.Transient mTOR inhibition facilitates continuous growth of liver tumors by modulating the maintenance of CD133+ cell populations.Synergistic therapeutic effect of cisplatin and phosphatidylinositol 3-kinase (PI3K) inhibitors in cancer growth and metastasis of Brca1 mutant tumors.Two hits are better than one: targeting both phosphatidylinositol 3-kinase and mammalian target of rapamycin as a therapeutic strategy for acute leukemia treatment.Side population in human non-muscle invasive bladder cancer enriches for cancer stem cells that are maintained by MAPK signalling.Modulation of A1 and A2B adenosine receptor activity: a new strategy to sensitise glioblastoma stem cells to chemotherapy.NVP-BEZ235, a novel dual PI3K/mTOR inhibitor, enhances the radiosensitivity of human glioma stem cells in vitro.Propagation of human prostate cancer stem-like cells occurs through EGFR-mediated ERK activation.A preclinical orthotopic model for glioblastoma recapitulates key features of human tumors and demonstrates sensitivity to a combination of MEK and PI3K pathway inhibitors.Maintenance of stemness in oxaliplatin-resistant hepatocellular carcinoma is associated with increased autocrine of IGF1.Akt signaling is required for glioblastoma maintenance in vivoCombined inhibition of AKT/mTOR and MDM2 enhances Glioblastoma Multiforme cell apoptosis and differentiation of cancer stem cells.HGUE-C-1 is an atypical and novel colon carcinoma cell line.Small-Molecule ONC201/TIC10 Targets Chemotherapy-Resistant Colorectal Cancer Stem-like Cells in an Akt/Foxo3a/TRAIL-Dependent Manner.Honokiol inhibits sphere formation and xenograft growth of oral cancer side population cells accompanied with JAK/STAT signaling pathway suppression and apoptosis inductionTargeting JNK for therapeutic depletion of stem-like glioblastoma cellsInhibition of histamine receptor 3 suppresses glioblastoma tumor growth, invasion, and epithelial-to-mesenchymal transition.Molecular-Based Recursive Partitioning Analysis Model for Glioblastoma in the Temozolomide Era: A Correlative Analysis Based on NRG Oncology RTOG 0525.Therapeutics targeting CD90-integrin-AMPK-CD133 signal axis in liver cancer.Estradiol-induced object recognition memory consolidation is dependent on activation of mTOR signaling in the dorsal hippocampusSingle-Cell Phosphoproteomics Resolves Adaptive Signaling Dynamics and Informs Targeted Combination Therapy in GlioblastomaGlioma-initiating cell elimination by metformin activation of FOXO3 via AMPK.Caveolin-1 is a negative regulator of tumor growth in glioblastoma and modulates chemosensitivity to temozolomideTranscriptional signaling pathways inversely regulated in Alzheimer's disease and glioblastoma multiform.Xtalk: a path-based approach for identifying crosstalk between signaling pathwaysEssential gene pathways for glioblastoma stem cells: clinical implications for prevention of tumor recurrence.A c-Met inhibitor increases the chemosensitivity of cancer stem cells to the irinotecan in gastric carcinoma.YB-1 dependent oncolytic adenovirus efficiently inhibits tumor growth of glioma cancer stem like cells.Signal transduction molecule patterns indicating potential glioblastoma therapy approaches.
P2860
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P2860
Crosstalk between the PI3K/mTOR and MEK/ERK pathways involved in the maintenance of self-renewal and tumorigenicity of glioblastoma stem-like cells.
description
2010 nĆ® lÅ«n-bĆ»n
@nan
2010幓ć®č«ę
@ja
2010幓č«ę
@yue
2010幓č«ę
@zh-hant
2010幓č«ę
@zh-hk
2010幓č«ę
@zh-mo
2010幓č«ę
@zh-tw
2010幓č®ŗę
@wuu
2010幓č®ŗę
@zh
2010幓č®ŗę
@zh-cn
name
Crosstalk between the PI3K/mTO ...... glioblastoma stem-like cells.
@en
Crosstalk between the PI3K/mTO ...... glioblastoma stem-like cells.
@nl
type
label
Crosstalk between the PI3K/mTO ...... glioblastoma stem-like cells.
@en
Crosstalk between the PI3K/mTO ...... glioblastoma stem-like cells.
@nl
prefLabel
Crosstalk between the PI3K/mTO ...... glioblastoma stem-like cells.
@en
Crosstalk between the PI3K/mTO ...... glioblastoma stem-like cells.
@nl
P2093
P356
P1433
P1476
Crosstalk between the PI3K/mTO ...... f glioblastoma stem-like cells
@en
P2093
Atsushi Sato
Chifumi Kitanaka
Jun Sunayama
Kaori Sakurada
Kaori Suzuki
Ken Tachibana
Ken-Ichiro Matsuda
Soichiro Shibui
Takamasa Kayama
Yoshitaka Narita
P2860
P304
P356
10.1002/STEM.521
P577
2010-11-01T00:00:00Z