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The multiple roles of the CD8 coreceptor in T cell biology: opportunities for the selective modulation of self-reactive cytotoxic T cellsMore tricks with tetramers: a practical guide to staining T cells with peptide-MHC multimersT-cell Receptor-optimized Peptide Skewing of the T-cell Repertoire Can Enhance Antigen TargetingPeptide length determines the outcome of TCR/peptide-MHCI engagementComparison of peptide-major histocompatibility complex tetramers and dextramers for the identification of antigen-specific T cells.Evidence that the density of self peptide-MHC ligands regulates T-cell receptor signaling.The human CD8β M-4 isoform dominant in effector memory T cells has distinct cytoplasmic motifs that confer unique properties.Antibody stabilization of peptide-MHC multimers reveals functional T cells bearing extremely low-affinity TCRsCD8(+) T cell cross-reactivity profiles and HIV-1 immune escape towards an HLA-B35-restricted immunodominant Nef epitope.Anti-CD8 antibodies can trigger CD8+ T cell effector function in the absence of TCR engagement and improve peptide-MHCI tetramer staining.A single autoimmune T cell receptor recognizes more than a million different peptides.Identification of human viral protein-derived ligands recognized by individual MHCI-restricted T-cell receptors.Enzymatic discovery of a HER-2/neu epitope that generates cross-reactive T cells.Cross-reactivity of T cells and its role in the immune systemCD4(+) and CD8(+) TCRβ repertoires possess different potentials to generate extraordinarily high-avidity T cells.HIV-1-Specific CD8 T Cells Exhibit Limited Cross-Reactivity during Acute Infection.Coreceptor affinity for MHC defines peptide specificity requirements for TCR interaction with coagonist peptide-MHC.Cellular-level versus receptor-level response threshold hierarchies in T-cell activation.Functional role of T-cell receptor nanoclusters in signal initiation and antigen discriminationTargeted suppression of autoreactive CD8(+) T-cell activation using blocking anti-CD8 antibodies.CD8+ T-cell specificity is compromised at a defined MHCI/CD8 affinity threshold.Advances in direct T-cell alloreactivity: function, avidity, biophysics and structure.The molecular determinants of CD8 co-receptor function.Co-Receptor CD8-Mediated Modulation of T-Cell Receptor Functional Sensitivity and Epitope Recognition Degeneracy.The T cell antigen receptor: the Swiss army knife of the immune system.Human leucocyte antigen class I-redirected anti-tumour CD4+ T cells require a higher T cell receptor binding affinity for optimal activity than CD8+ T cells.Structural Mechanism Underpinning Cross-reactivity of a CD8+ T-cell Clone That Recognizes a Peptide Derived from Human Telomerase Reverse Transcriptase.T cell Receptor Alpha Variable 12-2 bias in the immunodominant response to Yellow fever virus.Selective induction of CTL helper rather than killer activity by natural epitope variants promotes dendritic cell-mediated HIV-1 dissemination.Modulation of T-cell receptor functional sensitivity via the opposing actions of protein tyrosine kinases and phosphatases: a mathematical model.Peptide mimic for influenza vaccination using nonnatural combinatorial chemistry.Preclinical Strategies to Identify Off-Target Toxicity of High-Affinity TCRs.
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P2860
description
2010 nî lūn-bûn
@nan
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
2010年论文
@zh
2010年论文
@zh-cn
name
CD8 controls T cell cross-reactivity.
@en
CD8 controls T cell cross-reactivity.
@nl
type
label
CD8 controls T cell cross-reactivity.
@en
CD8 controls T cell cross-reactivity.
@nl
prefLabel
CD8 controls T cell cross-reactivity.
@en
CD8 controls T cell cross-reactivity.
@nl
P2093
P2860
P356
P1476
CD8 controls T cell cross-reactivity.
@en
P2093
Bruno Laugel
Hugo A van den Berg
Julia Ekeruche
Linda Wooldridge
Mathew Clement
P2860
P304
P356
10.4049/JIMMUNOL.1001480
P407
P577
2010-09-15T00:00:00Z