A critical role of integrin-linked kinase, ch-TOG and TACC3 in centrosome clustering in cancer cells.
about
ILK: a pseudokinase in the center stage of cell-matrix adhesion and signalingIntegrin-linked kinase regulates interphase and mitotic microtubule dynamicsMultiple cancer testis antigens function to support tumor cell mitotic fidelity.The novel actin/focal adhesion-associated protein MISP is involved in mitotic spindle positioning in human cells.Prolactin-induced protein is required for cell cycle progression in breast cancer.Causes and consequences of centrosome abnormalities in cancer.A phenanthrene derived PARP inhibitor is an extra-centrosomes de-clustering agent exclusively eradicating human cancer cellsp53 dependent centrosome clustering prevents multipolar mitosis in tetraploid cellsIntegrin-linked kinase modulates lipopolysaccharide- and Helicobacter pylori-induced nuclear factor κB-activated tumor necrosis factor-α production via regulation of p65 serine 536 phosphorylation.Anaphase catastrophe is a target for cancer therapyRegulation of mitotic cytoskeleton dynamics and cytokinesis by integrin-linked kinase in retinoblastoma cells.TACC3 promotes stemness and is a potential therapeutic target in hepatocellular carcinoma.Using Pharmacokinetic Profiles and Digital Quantification of Stained Tissue Microarrays as a Medium-Throughput, Quantitative Method for Measuring the Kinetics of Early Signaling Changes Following Integrin-Linked Kinase Inhibition in an In Vivo ModelA double-edged sword: how oncogenes and tumor suppressor genes can contribute to chromosomal instabilityIdentification of novel small molecule inhibitors of centrosome clustering in cancer cellsInactivation of the Hippo tumour suppressor pathway by integrin-linked kinase.Integrin-Linked Kinase (ILK) Deletion Disrupts Oligodendrocyte Development by Altering Cell CycleIntegrin-linked kinase: not so 'pseudo' after all.Centrosome clustering and chromosomal (in)stability: a matter of life and death.Centrosomes and cilia in human disease.Pulling it together: The mitotic function of TACC3.Let's huddle to prevent a muddle: centrosome declustering as an attractive anticancer strategy.Mitotic spindle multipolarity without centrosome amplification.Centrosome amplification, chromosomal instability and cancer: mechanistic, clinical and therapeutic issues.miR-543 functions as a tumor suppressor in glioma in vitro and in vivo.Integrin-linked kinase regulates senescence in an Rb-dependent manner in cancer cell lines.Integrin-linked kinase links dynactin-1/dynactin-2 with cortical integrin receptors to orient the mitotic spindle relative to the substratum.Quantitative multi-parametric evaluation of centrosome declustering drugs: centrosome amplification, mitotic phenotype, cell cycle and deathFunctions of the Tumor Suppressors p53 and Rb in Actin Cytoskeleton RemodelingA small compound targeting TACC3 revealed its different spatiotemporal contributions for spindle assembly in cancer cells.The centrosomal adaptor TACC3 and the microtubule polymerase chTOG interact via defined C-terminal subdomains in an Aurora-A kinase-independent manner.Bayesian inference of negative and positive selection in human cancers.Disruption of Tacc3 function leads to in vivo tumor regression.Using Cell Culture Models of Centrosome Amplification to Study Centrosome Clustering in Cancer.Transforming acidic coiled-coil-containing protein 3 (TACC3) overexpression in hepatocellular carcinomas is associated with "stemness" and epithelial-mesenchymal transition-related marker expression and a poor prognosis.
P2860
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P2860
A critical role of integrin-linked kinase, ch-TOG and TACC3 in centrosome clustering in cancer cells.
description
2010 nî lūn-bûn
@nan
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
2010年论文
@zh
2010年论文
@zh-cn
name
A critical role of integrin-li ...... me clustering in cancer cells.
@en
A critical role of integrin-li ...... me clustering in cancer cells.
@nl
type
label
A critical role of integrin-li ...... me clustering in cancer cells.
@en
A critical role of integrin-li ...... me clustering in cancer cells.
@nl
prefLabel
A critical role of integrin-li ...... me clustering in cancer cells.
@en
A critical role of integrin-li ...... me clustering in cancer cells.
@nl
P2093
P356
P1433
P1476
A critical role of integrin-li ...... me clustering in cancer cells.
@en
P2093
P2888
P304
P356
10.1038/ONC.2010.431
P407
P577
2010-09-13T00:00:00Z
P5875
P6179
1023195369