Decreased virulence of a pneumolysin-deficient strain of Streptococcus pneumoniae in murine meningitis. - Wikidata - wikimedia - TriplyDB

Decreased virulence of a pneumolysin-deficient strain of Streptococcus pneumoniae in murine meningitis.

Decreased virulence of a pneumolysin-deficient strain of Streptococcus pneumoniae in murine meningitis.

http://www.wikidata.org/entity/Q39663269

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Defense at the border: the blood-brain barrier versus bacterial foreigners The role of pneumolysin in pneumococcal pneumonia and meningitis Method for inducing experimental pneumococcal meningitis in outbred mice Global functional analyses of cellular responses to pore-forming toxins Rapid evolution of virulence and drug resistance in the emerging zoonotic pathogen Streptococcus suis Streptococcus pneumoniae stabilizes tumor necrosis factor alpha mRNA through a pathway dependent on p38 MAPK but independent of Toll-like receptors PavA of Streptococcus pneumoniae modulates adherence, invasion, and meningeal inflammation.Detection of large numbers of pneumococcal virulence genes in streptococci of the mitis group.Identification of invasive serotype 1 pneumococcal isolates that express nonhemolytic pneumolysin.Role of pore-forming toxins in bacterial infectious diseases.Pneumococcal neuraminidases A and B both have essential roles during infection of the respiratory tract and sepsis.Bacterial pore-forming cytolysins induce neuronal damage in a rat model of neonatal meningitis.Bacterial cytolysin during meningitis disrupts the regulation of glutamate in the brain, leading to synaptic damage.Contribution of different pneumococcal virulence factors to experimental meningitis in mice.Reduced release of pneumolysin by Streptococcus pneumoniae in vitro and in vivo after treatment with nonbacteriolytic antibiotics in comparison to ceftriaxone Extracellular calcium reduction strongly increases the lytic capacity of pneumolysin from streptococcus pneumoniae in brain tissue.Changes in astrocyte shape induced by sublytic concentrations of the cholesterol-dependent cytolysin pneumolysin still require pore-forming capacity.Persistence of pneumolysin in the cerebrospinal fluid of patients with pneumococcal meningitis is associated with mortality Pneumolysin in the immunopathogenesis and treatment of pneumococcal disease.Animal models of Streptococcus pneumoniae disease The surface-anchored NanA protein promotes pneumococcal brain endothelial cell invasion.Knockdown of the MAPK p38 pathway increases the susceptibility of Chilo suppressalis larvae to Bacillus thuringiensis Cry1Ca toxin.Airborne dust and high temperatures are risk factors for invasive bacterial disease.Recognition of Streptococcus pneumoniae by the innate immune system.Inflammasomes in Pneumococcal Infection: Innate Immune Sensing and Bacterial Evasion Strategies.Magnesium therapy improves outcome in Streptococcus pneumoniae meningitis by altering pneumolysin pore formation.Streptococcus pneumoniae-induced inhibition of rat ependymal cilia is attenuated by antipneumolysin antibody.Intermedilysin is essential for the invasion of hepatoma HepG2 cells by Streptococcus intermedius.MyD88 is required for mounting a robust host immune response to Streptococcus pneumoniae in the CNS.Astrocytic tissue remodeling by the meningitis neurotoxin pneumolysin facilitates pathogen tissue penetration and produces interstitial brain edema.Innate immunity to pneumococcal infection of the central nervous system depends on toll-like receptor (TLR) 2 and TLR4.

P2860

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P2860

Decreased virulence of a pneumolysin-deficient strain of Streptococcus pneumoniae in murine meningitis.

http://www.wikidata.org/entity/Q39663269

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2002 nî lūn-bûn

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Decreased virulence of a pneum ...... eumoniae in murine meningitis.

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Decreased virulence of a pneum ...... eumoniae in murine meningitis.

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Decreased virulence of a pneum ...... eumoniae in murine meningitis.

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Decreased virulence of a pneum ...... eumoniae in murine meningitis.

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Decreased virulence of a pneum ...... eumoniae in murine meningitis.

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Decreased virulence of a pneum ...... eumoniae in murine meningitis.

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IAI.70.11.6504-6508.2002

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Infection and Immunity

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Decreased virulence of a pneum ...... eumoniae in murine meningitis.

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Andreas Wellmer

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Gregor Zysk

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Helmut Eiffert

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Joachim Gerber

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Matthias Von Mering

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Roland Nau

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Stefanie Bunkowski

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Tammo Kunst

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P2860

Pneumolysin is the main inducer of cytotoxicity to brain microvascular endothelial cells caused by Streptococcus pneumoniae

Pneumococcal pneumolysin and H(2)O(2) mediate brain cell apoptosis during meningitis

Organotypic hippocampal cultures. A model of brain tissue damage in Streptococcus pneumoniae meningitis.

Proinflammatory interactions of pneumolysin with human neutrophils.

Protection against bacteremic pneumococcal infection by antibody to pneumolysin.

Molecular and cellular biology of pneumococcal infection.

Effect of deficiency of tumor necrosis factor alpha or both of its receptors on Streptococcus pneumoniae central nervous system infection and peritonitis.

The autolytic enzyme LytA of Streptococcus pneumoniae is not responsible for releasing pneumolysin

Comparative virulence of Streptococcus pneumoniae strains with insertion-duplication, point, and deletion mutations in the pneumolysin gene

Additive attenuation of virulence of Streptococcus pneumoniae by mutation of the genes encoding pneumolysin and other putative pneumococcal virulence proteins.

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6504-6508

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