The centrosomal protein TACC3 controls paclitaxel sensitivity by modulating a premature senescence program. - Wikidata - wikimedia - TriplyDB

The centrosomal protein TACC3 controls paclitaxel sensitivity by modulating a premature senescence program.

The centrosomal protein TACC3 controls paclitaxel sensitivity by modulating a premature senescence program.

http://www.wikidata.org/entity/Q39664652

about

Multiple cancer testis antigens function to support tumor cell mitotic fidelity.Cancer cell death induced by novel small molecules degrading the TACC3 protein via the ubiquitin-proteasome pathway.The mesh is a network of microtubule connectors that stabilizes individual kinetochore fibers of the mitotic spindle.High expression of TACC3 in esophageal squamous cell carcinoma correlates with poor prognosis.MicroRNA-15b regulates mitochondrial ROS production and the senescence-associated secretory phenotype through sirtuin 4/SIRT4 miR-30e controls DNA damage-induced stress responses by modulating expression of the CDK inhibitor p21WAF1/CIP1 and caspase-3.Cellular senescence or EGFR signaling induces Interleukin 6 (IL-6) receptor expression controlled by mammalian target of rapamycin (mTOR).Pulling it together: The mitotic function of TACC3.Aurora-A Kinase: A Potent Oncogene and Target for Cancer Therapy.PKCι depletion initiates mitotic slippage-induced senescence in glioblastoma Oncogenic FGFR3 gene fusions in bladder cancer.Centrosome aberrations associated with cellular senescence and p53 localization at supernumerary centrosomes.Regulation of paclitaxel activity by microtubule-associated proteins in cancer chemotherapy.FGFR3-TACC3 cancer gene fusions cause mitotic defects by removal of endogenous TACC3 from the mitotic spindle The centrosomal adaptor TACC3 and the microtubule polymerase chTOG interact via defined C-terminal subdomains in an Aurora-A kinase-independent manner.TACC3 in personalized medicine TACC3 as an independent prognostic marker for solid tumors: a systematic review and meta-analysis.Clinicopathological and prognostic value of transforming acidic coiled-coil-containing protein 3 (TACC3) expression in soft tissue sarcomas.Disruption of Tacc3 function leads to in vivo tumor regression.Transforming acidic coiled-coil-containing protein 3 (TACC3) overexpression in hepatocellular carcinomas is associated with "stemness" and epithelial-mesenchymal transition-related marker expression and a poor prognosis.Oncogenic driver FGFR3-TACC3 is dependent on membrane trafficking and ERK signaling

P2860

Q29871492-506DE0C8-A880-4D9A-A75F-230A8665B845 Q34662199-F4AE7AA6-F520-4E58-A1E1-1C03EF3D3B55 Q35668564-00C9D7EE-EA61-4CCF-90C7-937364AB73F9 Q35740091-AFE9071F-76F1-4C40-870C-752D563C2991 Q36802020-42864F6F-FFD0-45D9-9B10-D6282D3C0869 Q37085916-C7A2B19E-C282-45E8-9758-53E7199CEA31 Q37492314-CACC8B78-7252-4CA2-B32B-37D86F6D583B Q37933071-717DF801-7010-4CE6-B857-E0F84213121A Q38894287-5BB70224-1CDE-47CD-B90B-345CBDF89A9D Q38981503-07344347-3C3D-4308-8FBD-2A71952EC197 Q39240290-B92A87E3-1D9B-443F-AC49-3AF334A2D895 Q39254584-2296CF52-4FB7-418F-9152-A4D463067533 Q39456292-2E4909FE-4BC7-4CFE-83D1-C9E84A784350 Q41567166-10C447D8-1009-46B5-8852-6771F89D7FF8 Q41848433-1CD4705C-83B3-4D28-9E07-FA94CF250AF4 Q42087478-A4EDE5DF-897D-4C62-AC2B-8267CE1BC88D Q43050437-5EC3998D-AE50-477A-A8DC-A135BC18ACFB Q45994976-D99F5E66-3294-407E-983C-C670946FEC69 Q52612716-4120C10E-CA9D-4ECF-AFE1-E5E40D226676 Q53204532-6D959B2E-3614-4916-9BA0-A5471037661C Q57821064-2C132768-2A42-4D14-8686-6F8BEE395CFB

P2860

The centrosomal protein TACC3 controls paclitaxel sensitivity by modulating a premature senescence program.

http://www.wikidata.org/entity/Q39664652

description

2010 nî lūn-bûn

@nan

2010年の論文

@ja

2010年論文

@yue

2010年論文

@zh-hant

2010年論文

@zh-hk

2010年論文

@zh-mo

2010年論文

@zh-tw

2010年论文

@wuu

2010年论文

@zh

2010年论文

@zh-cn

name

The centrosomal protein TACC3 ...... premature senescence program.

@en

The centrosomal protein TACC3 ...... premature senescence program.

@nl

type

label

The centrosomal protein TACC3 ...... premature senescence program.

@en

The centrosomal protein TACC3 ...... premature senescence program.

@nl

prefLabel

The centrosomal protein TACC3 ...... premature senescence program.

@en

The centrosomal protein TACC3 ...... premature senescence program.

@nl

P1433

Q39664652-C716505C-7B35-4DB0-93A6-8AF1F8293B31

P1476

Q39664652-CFE72670-CB8F-4724-A251-8090DEA075C6

P2093

Q39664652-009D4AF0-299C-4179-BB4F-519183FB427F

Q39664652-2523EB90-0058-49BA-A99C-0899288AD261

Q39664652-480DC025-76B0-4859-99A2-317C31A4C37B

Q39664652-53C54682-8A8A-4F15-9F99-CA068159549C

Q39664652-60727518-7954-4896-835A-7585E8EAF0D2

Q39664652-76AD2915-F1A9-4E44-8736-FA4D2A558714

Q39664652-87BE1386-A282-4FD0-99BB-A0C821C67DA4

Q39664652-CECE15C5-231B-4FCE-AC0F-397CF3693A46

Q39664652-D085E49D-C601-4046-BA03-7D2506425D92

Q39664652-EAB93BF0-1453-43AE-A15B-5E94D07450FF

P2860

Q39664652-01BA4C7C-56F1-4817-8CA9-CD2F9BBED458

Q39664652-04392A4B-70E0-43C9-B374-7752D77CD50D

Q39664652-0F013531-BD40-4840-B4D6-897463A8BAD3

Q39664652-14621406-0ECE-46F3-8A39-9AB72D687434

Q39664652-15255C9A-450A-4BDC-9457-341E9ACA3E05

Q39664652-180C4BB3-48BB-4CBA-941B-CA8034FB277F

Q39664652-1834E75A-65C5-4C37-80AE-057A16762E3A

Q39664652-1A31CD61-D814-4988-8F98-B6ACDDC3E95C

Q39664652-1EB618E3-FA5C-4F94-88AB-143D796D9F19

Q39664652-227DA185-7F27-4B29-A83B-244909F98744

P2888

Q39664652-C2ADBD63-C635-4707-A6C8-41F6D204579F

P304

Q39664652-087BEC57-30CD-4148-8C0B-0F591A3F253F

P31

Q39664652-EC1E277D-FD86-4DBE-B3C3-FE7FF46338DD

P356

Q39664652-F6051CE1-5553-4DEE-B34C-8FBBA861E4B4

P407

Q39664652-BD9236B1-0FE7-4067-A6AB-0B3F1F8BCF81

P433

Q39664652-C7E04559-CAF7-4CB4-83A4-E9D71365557C

P478

Q39664652-35AD88B2-A63F-48E8-A534-7E9DEDB8333E

P50

Q39664652-7CFBA820-4105-4B35-8429-05612C9F905B

P577

Q39664652-8DDC536C-C815-45D8-A217-3E7F557DC21C

P5875

Q39664652-5B1B444F-66B6-4734-9B04-E739D93ACF27

P698

Q39664652-849ECAFC-7B72-43CA-AD73-49129501314D

P356

P1433

P1476

The centrosomal protein TACC3 ...... premature senescence program.

@en

P2093

A Kletke

http://www.w3.org/2001/XMLSchema#string

B Nürnberg

http://www.w3.org/2001/XMLSchema#string

C Wiek

http://www.w3.org/2001/XMLSchema#string

F Essmann

http://www.w3.org/2001/XMLSchema#string

F Kuck

http://www.w3.org/2001/XMLSchema#string

H Hanenberg

http://www.w3.org/2001/XMLSchema#string

I C Cirstea

http://www.w3.org/2001/XMLSchema#string

K Schulze-Osthoff

http://www.w3.org/2001/XMLSchema#string

M R Ahmadian

http://www.w3.org/2001/XMLSchema#string

R P Piekorz

http://www.w3.org/2001/XMLSchema#string

P2860

TOGp, the human homolog of XMAP215/Dis1, is required for centrosome integrity, spindle pole organization, and bipolar spindle assembly

The centrosomal protein TACC3 is essential for hematopoietic stem cell function and genetically interfaces with p53-regulated apoptosis

Mitotic checkpoint slippage in humans occurs via cyclin B destruction in the presence of an active checkpoint.

The ch-TOG/XMAP215 protein is essential for spindle pole organization in human somatic cells

Aberrations of TACC1 and TACC3 are associated with ovarian cancer

CENP-A phosphorylation by Aurora-A in prophase is required for enrichment of Aurora-B at inner centromeres and for kinetochore function

The transcriptional targets of p53 in apoptosis control

PEA-15 is inhibited by adenovirus E1A and plays a role in ERK nuclear export and Ras-induced senescence

Acute mutation of retinoblastoma gene function is sufficient for cell cycle re-entry

Caspase-3 is required for DNA fragmentation and morphological changes associated with apoptosis

P2888

P304

6184-6192

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1038/ONC.2010.354

http://www.w3.org/2001/XMLSchema#string

P407

P433

46

http://www.w3.org/2001/XMLSchema#string

P478

29

http://www.w3.org/2001/XMLSchema#string

P50

Leonid Schneider

P577

2010-08-23T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

45800329

http://www.w3.org/2001/XMLSchema#string

P698

20729911

http://www.w3.org/2001/XMLSchema#string