14-3-3 adaptor proteins recruit AID to 5'-AGCT-3'-rich switch regions for class switch recombination.
about
Solubility-based genetic screen identifies RING finger protein 126 as an E3 ligase for activation-induced cytidine deaminaseEndonuclease G plays a role in immunoglobulin class switch DNA recombination by introducing double-strand breaks in switch regionsBCR-signalling synergizes with TLR-signalling for induction of AID and immunoglobulin class-switching through the non-canonical NF-κB pathwayEpigenetics of Peripheral B-Cell Differentiation and the Antibody ResponseMolecular programming of B cell memoryRegulation of Aicda expression and AID activityTranscriptional stalling in B-lymphocytes: a mechanism for antibody diversification and maintenance of genomic integrityIgH chain class switch recombination: mechanism and regulationAID targeting is dependent on RNA polymerase II pausing.AID/APOBEC deaminases and cancerAID targeting: old mysteries and new challengesAID and Apobec3G haphazard deamination and mutational diversityProximity to AGCT sequences dictates MMR-independent versus MMR-dependent mechanisms for AID-induced mutation via UNG2.Binding of AID to DNA does not correlate with mutator activity.B cell TLRs and induction of immunoglobulin class-switch DNA recombination.Clustered and genome-wide transient mutagenesis in human cancers: Hypermutation without permanent mutators or loss of fitnessRegulation of immunoglobulin class-switch recombination: choreography of noncoding transcription, targeted DNA deamination, and long-range DNA repair.Lysine residue at position 22 of the AID protein regulates its class switch activity.Estrogen receptors bind to and activate the HOXC4/HoxC4 promoter to potentiate HoxC4-mediated activation-induced cytosine deaminase induction, immunoglobulin class switch DNA recombination, and somatic hypermutationHistone deacetylase inhibitors upregulate B cell microRNAs that silence AID and Blimp-1 expression for epigenetic modulation of antibody and autoantibody responses.Complex regulation and function of activation-induced cytidine deaminase.Scaffold functions of 14-3-3 adaptors in B cell immunoglobulin class switch DNA recombination.Epigenetic tethering of AID to the donor switch region during immunoglobulin class switch recombination.14-3-3 proteins restrain the Exo1 nuclease to prevent overresection.Non-coding RNA Generated following Lariat Debranching Mediates Targeting of AID to DNAActivation-induced cytidine deaminase (AID)-dependent somatic hypermutation requires a splice isoform of the serine/arginine-rich (SR) protein SRSF1Iron inhibits activation-induced cytidine deaminase enzymatic activity and modulates immunoglobulin class switch DNA recombination.Role of glial 14-3-3 gamma protein in autoimmune demyelination.AIDing antibody diversity by error-prone mismatch repair.A structural basis for the biochemical behavior of activation-induced deoxycytidine deaminase class-switch recombination-defective hyper-IgM-2 mutantsCombinatorial mechanisms regulating AID-dependent DNA deamination: interacting proteins and post-translational modifications.Genome-Wide Analysis Reveals Selective Modulation of microRNAs and mRNAs by Histone Deacetylase Inhibitor in B Cells Induced to Undergo Class-Switch DNA Recombination and Plasma Cell Differentiation.Immunoglobulin class-switch DNA recombination: induction, targeting and beyond.Activation-induced Cytidine Deaminase in B Cell Immunity and Cancers.Interplay between Target Sequences and Repair Pathways Determines Distinct Outcomes of AID-Initiated LesionsClose proximity to Igh is a contributing factor to AID-mediated translocations.Hotspots for Vitamin-Steroid-Thyroid Hormone Response Elements Within Switch Regions of Immunoglobulin Heavy Chain Loci Predict a Direct Influence of Vitamins and Hormones on B Cell Class Switch Recombination.GANP regulates recruitment of AID to immunoglobulin variable regions by modulating transcription and nucleosome occupancy.Epigenetics of the antibody responseAID dysregulation in lupus-prone MRL/Fas(lpr/lpr) mice increases class switch DNA recombination and promotes interchromosomal c-Myc/IgH loci translocations: modulation by HoxC4
P2860
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P2860
14-3-3 adaptor proteins recruit AID to 5'-AGCT-3'-rich switch regions for class switch recombination.
description
2010 nî lūn-bûn
@nan
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
2010年论文
@zh
2010年论文
@zh-cn
name
14-3-3 adaptor proteins recrui ...... or class switch recombination.
@en
14-3-3 adaptor proteins recrui ...... or class switch recombination.
@nl
type
label
14-3-3 adaptor proteins recrui ...... or class switch recombination.
@en
14-3-3 adaptor proteins recrui ...... or class switch recombination.
@nl
prefLabel
14-3-3 adaptor proteins recrui ...... or class switch recombination.
@en
14-3-3 adaptor proteins recrui ...... or class switch recombination.
@nl
P2093
P2860
P356
P1476
14-3-3 adaptor proteins recrui ...... for class switch recombination
@en
P2093
Ahmed Al-Qahtani
Bruce Herron
Clayton A White
Egest J Pone
John Yates
Lisa M Thomas
Markus Otto
P2860
P2888
P304
P356
10.1038/NSMB.1884
P577
2010-08-22T00:00:00Z