Molecular steps of G-overhang generation at human telomeres and its function in chromosome end protection
about
CTC1 deletion results in defective telomere replication, leading to catastrophic telomere loss and stem cell exhaustionMERISTEM DISORGANIZATION1 encodes TEN1, an essential telomere protein that modulates telomerase processivity in Arabidopsis.Xenopus laevis Ctc1-Stn1-Ten1 (xCST) protein complex is involved in priming DNA synthesis on single-stranded DNA template in Xenopus egg extract.Human CST promotes telomere duplex replication and general replication restart after fork stalling.The role of double-strand break repair pathways at functional and dysfunctional telomeres.POT1a and components of CST engage telomerase and regulate its activity in Arabidopsis.Stn1 is critical for telomere maintenance and long-term viability of somatic human cells.Early and late steps in telomere overhang processing in normal human cells: the position of the final RNA primer drives telomere shorteningNEK6-mediated phosphorylation of human TPP1 regulates telomere length through telomerase recruitment.Tying up the Ends: Plasticity in the Recognition of Single-Stranded DNA at Telomeres.STN1 OB Fold Mutation Alters DNA Binding and Affects Selective Aspects of CST Function.CDK1 differentially regulates G-overhang generation at leading- and lagging-strand telomeres in telomerase-negative cells in G2 phase.HnRNP A1 phosphorylated by VRK1 stimulates telomerase and its binding to telomeric DNA sequence.Complex interactions between the DNA-damage response and mammalian telomeres.Suppression of STN1 enhances the cytotoxicity of chemotherapeutic agents in cancer cells by elevating DNA damage.Mutations in STN1 cause Coats plus syndrome and are associated with genomic and telomere defects.Telomere replication: poised but puzzlingTelomere-end processing: mechanisms and regulation.Modelling the regulation of telomere length: the effects of telomerase and G-quadruplex stabilising drugs.Beyond Telomerase: Telomere Instability as a Novel Target for Cancer Therapy.Potential Risks in the Paradigm of Basic to Translational Research: A Critical Evaluation of qPCR Telomere Size Techniques.Telomeres in cancer: tumour suppression and genome instability.Telomerase Mechanism of Telomere Synthesis.Human Stn1 protects telomere integrity by promoting efficient lagging-strand synthesis at telomeres and mediating C-strand fill-in.Mapping the FEN1 interaction domain with hTERT.For cancers there is more to life than a longer G-strand.Telomeric 3' overhangs derive from resection by Exo1 and Apollo and fill-in by POT1b-associated CST.Oligonucleotide models of telomeric DNA and RNA form a Hybrid G-quadruplex structure as a potential component of telomeresTelomerase-dependent 3' G-strand overhang maintenance facilitates GTBP1-mediated telomere protection from misplaced homologous recombination.Telomerase activity is required for the telomere G-overhang structure in Trypanosoma brucei.The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer on the G strand of the telomere
P2860
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P2860
Molecular steps of G-overhang generation at human telomeres and its function in chromosome end protection
description
2010 nî lūn-bûn
@nan
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
2010年论文
@zh
2010年论文
@zh-cn
name
Molecular steps of G-overhang ...... n in chromosome end protection
@en
Molecular steps of G-overhang ...... in chromosome end protection.
@nl
type
label
Molecular steps of G-overhang ...... n in chromosome end protection
@en
Molecular steps of G-overhang ...... in chromosome end protection.
@nl
prefLabel
Molecular steps of G-overhang ...... n in chromosome end protection
@en
Molecular steps of G-overhang ...... in chromosome end protection.
@nl
P2093
P2860
P356
P1433
P1476
Molecular steps of G-overhang ...... n in chromosome end protection
@en
P2093
Amruta Bhusari
Chenhui Huang
Kathryn Schubert
Shilpa Sampathi
Weihang Chai
P2860
P304
P356
10.1038/EMBOJ.2010.156
P407
P577
2010-07-16T00:00:00Z