Ikaros null mice display defects in T cell selection and CD4 versus CD8 lineage decisions.
about
The Ikaros transcription factor regulates responsiveness to IL-12 and expression of IL-2 receptor alpha in mature, activated CD8 T cells.Transcriptional repressors, corepressors and chromatin modifying enzymes in T cell development.Lineage fate and intense debate: myths, models and mechanisms of CD4- versus CD8-lineage choice.Specificity and dynamics of effector and memory CD8 T cell responses in human tick-borne encephalitis virus infection.Regulation of gene expression dynamics during developmental transitions by the Ikaros transcription factor.Regulation of chromatin structure during thymic T cell development.Ikaros mediates gene silencing in T cells through Polycomb repressive complex 2.Commitment issues: linking positive selection signals and lineage diversification in the thymus.Insulin-InsR signaling drives multipotent progenitor differentiation toward lymphoid lineages.Ikaros is required to survive positive selection and to maintain clonal diversity during T-cell development in the thymus.Ikaros sets the potential for Th17 lineage gene expression through effects on chromatin state in early T cell development.Cutting Edge: Ikaros null thymocytes mature into the CD4 lineage with reduced TCR signal: A study using CD3{zeta} immunoreceptor tyrosine-based activation motif transgenic mice.Ikaros regulates Notch target gene expression in developing thymocytes.B-lineage transcription factors and cooperating gene lesions required for leukemia development.Ikaros directly represses the notch target gene Hes1 in a leukemia T cell line: implications for CD4 regulationIkaros' suspended flight in the thymus.Ikaros in B cell development and function.Suppression of SRCAP chromatin remodelling complex and restriction of lymphoid lineage commitment by Pcid2.Expression patterns of Ikaros family members during positive selection and lineage commitment of human thymocytes.
P2860
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P2860
Ikaros null mice display defects in T cell selection and CD4 versus CD8 lineage decisions.
description
2004 nî lūn-bûn
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2004年の論文
@ja
2004年学术文章
@wuu
2004年学术文章
@zh-cn
2004年学术文章
@zh-hans
2004年学术文章
@zh-my
2004年学术文章
@zh-sg
2004年學術文章
@yue
2004年學術文章
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2004年學術文章
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name
Ikaros null mice display defec ...... versus CD8 lineage decisions.
@en
Ikaros null mice display defec ...... versus CD8 lineage decisions.
@nl
type
label
Ikaros null mice display defec ...... versus CD8 lineage decisions.
@en
Ikaros null mice display defec ...... versus CD8 lineage decisions.
@nl
prefLabel
Ikaros null mice display defec ...... versus CD8 lineage decisions.
@en
Ikaros null mice display defec ...... versus CD8 lineage decisions.
@nl
P1476
Ikaros null mice display defec ...... versus CD8 lineage decisions.
@en
P2093
Julie A Urban
Susan Winandy
P304
P356
10.4049/JIMMUNOL.173.7.4470
P407
P577
2004-10-01T00:00:00Z