Lineage fate and intense debate: myths, models and mechanisms of CD4- versus CD8-lineage choice. - Wikidata - wikimedia - TriplyDB

Lineage fate and intense debate: myths, models and mechanisms of CD4- versus CD8-lineage choice.

Lineage fate and intense debate: myths, models and mechanisms of CD4- versus CD8-lineage choice.

http://www.wikidata.org/entity/Q34831201

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Tespa1 is involved in late thymocyte development through the regulation of TCR-mediated signaling Interchangeability of Themis1 and Themis2 in thymocyte development reveals two related proteins with conserved molecular function GATA3 and the T-cell lineage: essential functions before and after T-helper-2-cell differentiation Themis, a T cell-specific protein important for late thymocyte development Control of the thymic medulla and its influence on αβT-cell development Laminin-Mediated Interactions in Thymocyte Migration and Development A Tale from TGF-β Superfamily for Thymus Ontogeny and Function Translating transitions - how to decipher peripheral human B cell development T Cell Adolescence: Maturation Events Beyond Positive Selection The multiple roles of the CD8 coreceptor in T cell biology: opportunities for the selective modulation of self-reactive cytotoxic T cells Double-negative T cells during HIV/SIV infections: potential pinch hitters in the T-cell lineup Transcriptional control of CD4 and CD8 coreceptor expression during T cell development The epigenetic landscape of lineage choice: lessons from the heritability of CD4 and CD8 expression EBV promotes human CD8 NKT cell development The thymus and rheumatology: should we care?The sequential activity of Gata3 and Thpok is required for the differentiation of CD1d-restricted CD4+ NKT cells Regulation of GATA-3 expression during CD4 lineage differentiation.LKB1 regulates TCR-mediated PLCγ1 activation and thymocyte positive selection Regulatory T cells: mechanisms of differentiation and function ShcA regulates late stages of T cell development and peripheral CD4+ T cell numbers.Inhibins tune the thymocyte selection process by regulating thymic stromal cell differentiation ATP-binding cassette transporter G1 negatively regulates thymocyte and peripheral lymphocyte proliferation.c-Myb promotes the survival of CD4+CD8+ double-positive thymocytes through upregulation of Bcl-xL Wishbone identifies bifurcating developmental trajectories from single-cell data.Ubc9 Is Required for Positive Selection and Late-Stage Maturation of Thymocytes.The transcription factor Ets1 is important for CD4 repression and Runx3 up-regulation during CD8 T cell differentiation in the thymus.Overlapping and asymmetric functions of TCR signaling during thymic selection of CD4 and CD8 lineages Unexpected role of clathrin adaptor AP-1 in MHC-dependent positive selection of T cells The transcription factors Thpok and LRF are necessary and partly redundant for T helper cell differentiation A silencer-proximal intronic region is required for sustained CD4 expression in postselection thymocytes TCF-1 and LEF-1 act upstream of Th-POK to promote the CD4(+) T cell fate and interact with Runx3 to silence Cd4 in CD8(+) T cells Co-receptor choice by V alpha14i NKT cells is driven by Th-POK expression rather than avoidance of CD8-mediated negative selection.TCF1 and beta-catenin regulate T cell development and function Gene enrichment profiles reveal T-cell development, differentiation, and lineage-specific transcription factors including ZBTB25 as a novel NF-AT repressor.Fine-tuning T cell receptor signaling to control T cell development TCR ligand density and affinity determine peripheral induction of Foxp3 in vivo.Controlled major histocompatibility complex-T cell receptor signaling allows efficient generation of functional, antigen-specific CD8+ T cells from embryonic stem cells and thymic progenitors.Tenuous paths in unexplored territory: From T cell receptor signaling to effector gene expression during thymocyte selection.Transcriptional control of invariant NKT cell development.The microRNA biogenesis machinery modulates lineage commitment during αβ T cell development.

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Lineage fate and intense debate: myths, models and mechanisms of CD4- versus CD8-lineage choice.

http://www.wikidata.org/entity/Q34831201

description

2008 nî lūn-bûn

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2008 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած

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2008 թվականի հոտեմբերին հրատարակված գիտական հոդված

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2008年の論文

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2008年論文

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2008年論文

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2008年論文

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2008年論文

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2008年论文

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name

Lineage fate and intense debat ...... D4- versus CD8-lineage choice.

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Lineage fate and intense debat ...... D4- versus CD8-lineage choice.

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Lineage fate and intense debat ...... D4- versus CD8-lineage choice.

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type

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Lineage fate and intense debat ...... D4- versus CD8-lineage choice.

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Lineage fate and intense debat ...... D4- versus CD8-lineage choice.

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Lineage fate and intense debat ...... D4- versus CD8-lineage choice.

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Lineage fate and intense debat ...... D4- versus CD8-lineage choice.

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Lineage fate and intense debat ...... D4- versus CD8-lineage choice.

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Lineage fate and intense debat ...... D4- versus CD8-lineage choice.

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Nature Reviews Immunology

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Lineage fate and intense debat ...... D4- versus CD8-lineage choice.

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P2093

Alfred Singer

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Jung-Hyun Park

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Stanley Adoro

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P2860

Signal for T-cell differentiation to a CD4 cell lineage is delivered by CD4 transmembrane region and/or cytoplasmic tail

Essential role for ZAP-70 in both positive and negative selection of thymocytes

c-Krox, a transcriptional regulator of type I collagen gene expression, is preferentially expressed in skin

Interaction between CD4 and class II MHC molecules mediates cell adhesion

TOX provides a link between calcineurin activation and CD8 lineage commitment

Development of all CD4 T lineages requires nuclear factor TOX

Functional cleavage of the common cytokine receptor gamma chain (gammac) by calpain

Reciprocal regulation of CD4/CD8 expression by SWI/SNF-like BAF complexes

The chromatin remodeler Mi-2beta is required for CD4 expression and T cell development

Critical roles for transcription factor GATA-3 in thymocyte development

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788-801

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10.1038/NRI2416

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10

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8

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