Transient ATM kinase inhibition disrupts DNA damage-induced sister chromatid exchange. - Wikidata - wikimedia - TriplyDB

Transient ATM kinase inhibition disrupts DNA damage-induced sister chromatid exchange.

Transient ATM kinase inhibition disrupts DNA damage-induced sister chromatid exchange.

http://www.wikidata.org/entity/Q39697685

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Evidence that BRCA1- or BRCA2-associated cancers are not inevitable Recombination phenotypes of the NCI-60 collection of human cancer cells.ATM signalling and cancer.The role of ATM in the deficiency in nonhomologous end-joining near telomeres in a human cancer cell line.ATR kinase activation in G1 phase facilitates the repair of ionizing radiation-induced DNA damage.Tug of war between survival and death: exploring ATM function in cancer.Differential phosphorylation of DNA-PKcs regulates the interplay between end-processing and end-ligation during nonhomologous end-joining.ATM protein physically and functionally interacts with proliferating cell nuclear antigen to regulate DNA synthesis.Homologous chromosomes make contact at the sites of double-strand breaks in genes in somatic G0/G1-phase human cells.Kinase-dead ATM protein causes genomic instability and early embryonic lethality in mice Quantitative proteomics reveal ATM kinase-dependent exchange in DNA damage response complexes.Ataxia telangiectasia mutated (ATM) is dispensable for endonuclease I-SceI-induced homologous recombination in mouse embryonic stem cells.The orally active and bioavailable ATR kinase inhibitor AZD6738 potentiates the anti-tumor effects of cisplatin to resolve ATM-deficient non-small cell lung cancer in vivo.Double-strand break repair by homologous recombination in primary mouse somatic cells requires BRCA1 but not the ATM kinase ATM kinase inhibition preferentially sensitizes p53-mutant glioma to ionizing radiation Kinase-dead ATM protein is highly oncogenic and can be preferentially targeted by Topo-isomerase I inhibitors X Chromosome Crossover Formation and Genome Stability in Caenorhabditis elegans Are Independently Regulated by xnd-1.Pharmacologic ATM but not ATR kinase inhibition abrogates p21-dependent G1 arrest and promotes gastrointestinal syndrome after total body irradiation.ATM protein is deficient in over 40% of lung adenocarcinomas.The ATM kinase signaling induced by the low-energy β-particles emitted by (33)P is essential for the suppression of chromosome aberrations and is greater than that induced by the energetic β-particles emitted by (32)P.CGK733 does not inhibit ATM or ATR kinase activity in H460 human lung cancer cells.LC-MS/MS assay for the simultaneous quantitation of the ATM inhibitor AZ31 and the ATR inhibitor AZD6738 in mouse plasma.Emerging targets for radioprotection and radiosensitization in radiotherapy.Discordance between phosphorylation and recruitment of 53BP1 in response to DNA double-strand breaks.Dynamic inhibition of ATM kinase provides a strategy for glioblastoma multiforme radiosensitization and growth control.Aurora-B mediated ATM serine 1403 phosphorylation is required for mitotic ATM activation and the spindle checkpoint.Inhibition of ATM kinase activity does not phenocopy ATM protein disruption: implications for the clinical utility of ATM kinase inhibitors.Human papillomavirus episome stability is reduced by aphidicolin and controlled by DNA damage response pathways.The genomics of lung adenocarcinoma: opportunities for targeted therapies.Differential epithelium DNA damage response to ATM and DNA-PK pathway inhibition in human prostate tissue culture.Mdmx promotes genomic instability independent of p53 and Mdm2.ATM loss leads to synthetic lethality in BRCA1 BRCT mutant mice associated with exacerbated defects in homology-directed repair.Nuclear myosin/actin-motored contact between homologous chromosomes is initiated by ATM kinase and homology-directed repair proteins at double-strand DNA breaks to suppress chromosome rearrangements.The brain-penetrant clinical ATM inhibitor AZD1390 radiosensitizes and improves survival of preclinical brain tumor models.Homology-Directed Repair and the Role of BRCA1, BRCA2, and Related Proteins in Genome Integrity and Cancer

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Transient ATM kinase inhibition disrupts DNA damage-induced sister chromatid exchange.

http://www.wikidata.org/entity/Q39697685

description

2010 nî lūn-bûn

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2010年の論文

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2010年学术文章

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2010年学术文章

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2010年学术文章

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2010年学术文章

@zh-my

2010年学术文章

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2010年學術文章

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2010年學術文章

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2010年學術文章

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name

Transient ATM kinase inhibition disrupts DNA damage-induced sister chromatid exchange.

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Transient ATM kinase inhibition disrupts DNA damage-induced sister chromatid exchange.

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type

label

Transient ATM kinase inhibition disrupts DNA damage-induced sister chromatid exchange.

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Transient ATM kinase inhibition disrupts DNA damage-induced sister chromatid exchange.

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prefLabel

Transient ATM kinase inhibition disrupts DNA damage-induced sister chromatid exchange.

@en

Transient ATM kinase inhibition disrupts DNA damage-induced sister chromatid exchange.

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Science Signaling

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Transient ATM kinase inhibition disrupts DNA damage-induced sister chromatid exchange.

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Christopher J Bakkenist

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Jason S White

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Serah Choi

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P2860

Linkage of ATM to cell cycle regulation by the Chk2 protein kinase

DNA T OPOISOMERASES : Structure, Function, and Mechanism

Cellular roles of dna topoisomerases: a molecular perspective

Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis

ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage

Activation of the ATM kinase by ionizing radiation and phosphorylation of p53

A single ataxia telangiectasia gene with a product similar to PI-3 kinase

CDK targets Sae2 to control DNA-end resection and homologous recombination

Normal cell cycle and checkpoint responses in mice and cells lacking Cdc25B and Cdc25C protein phosphatases.

How the fanconi anemia pathway guards the genome

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