Tolerance for mutations and chemical modifications in a siRNA. - Wikidata - wikimedia - TriplyDB

Tolerance for mutations and chemical modifications in a siRNA.

Tolerance for mutations and chemical modifications in a siRNA.

http://www.wikidata.org/entity/Q39698017

about

Designing of highly effective complementary and mismatch siRNAs for silencing a gene Small interfering RNAs containing full 2'-O-methylribonucleotide-modified sense strands display Argonaute2/eIF2C2-dependent activity.Light-dependent RNA interference with nucleobase-caged siRNAs siRNA target site secondary structure predictions using local stable substructures Towards in vivo application of RNA interference - new toys, old problems Locked nucleic acid (LNA) mediated improvements in siRNA stability and functionality HIV-1 can escape from RNA interference by evolving an alternative structure in its RNA genome A systematic analysis of the silencing effects of an active siRNA at all single-nucleotide mismatched target sites A rapid and sensitive assay for quantification of siRNA efficiency and specificity Tolerated wobble mutations in siRNAs decrease specificity, but can enhance activity in vivo.Improvements in siRNA properties mediated by 2'-deoxy-2'-fluoro-beta-D-arabinonucleic acid (FANA)Therapeutic Oligonucleotides Targeting Liver Disease: TTR Amyloidosis siRNA Versus miRNA as Therapeutics for Gene Silencing RNA mediated Toll-like receptor stimulation in health and disease Argonaute-dependent small RNAs derived from single-stranded, non-structured precursors Amides are excellent mimics of phosphate internucleoside linkages and are well tolerated in short interfering RNAs Technologies for controlled, local delivery of siRNA Structural basis for overhang-specific small interfering RNA recognition by the PAZ domain A combined computational-experimental approach predicts human microRNA targets Small RNAs with imperfect match to endogenous mRNA repress translation. Implications for off-target activity of small inhibitory RNA in mammalian cells.Sniffing for gene-silencing efficiency of siRNAs in HeLa cells in comparison with that in HEK293T cells: correlation between knockdown efficiency and sustainability of sirnas revealed by FRET-based probing A universal plasmid library encoding all permutations of small interfering RNA.Short interfering RNA (siRNA) as a novel therapeutic.Designing siRNA that distinguish between genes that differ by a single nucleotide Improving model predictions for RNA interference activities that use support vector machine regression by combining and filtering features.Chemical modification: the key to clinical application of RNA interference?Analysis of siRNA specificity on targets with double-nucleotide mismatches RNA modulators of complex phenotypes in mammalian cells.Inhibitors of MyD88-dependent proinflammatory cytokine production identified utilizing a novel RNA interference screening approach Effects of chemical modification on the potency, serum stability, and immunostimulatory properties of short shRNAs.High-density lipoproteins for the systemic delivery of short interfering RNA.siRNA-like double-stranded RNAs are specifically protected against degradation in human cell extract.Effect of chemical modifications on modulation of gene expression by duplex antigene RNAs that are complementary to non-coding transcripts at gene promoters.Improved siRNA/shRNA functionality by mismatched duplex.Global analysis of the mammalian RNA degradome reveals widespread miRNA-dependent and miRNA-independent endonucleolytic cleavage.Optimizations of siRNA design for the activation of gene transcription by targeting the TATA-box motif.siRNA therapeutics: big potential from small RNAs.siRNAmod: A database of experimentally validated chemically modified siRNAs SiRNA sequence model: redesign algorithm based on available genome-wide libraries.A role for human Dicer in pre-RISC loading of siRNAs.

P2860

Q21560930-B97140E2-ED7A-4AAA-9B8A-DE3B828FE8E9 Q24537508-366B4DF5-4364-472D-9CEC-3BDA72E89594 Q24676555-F29A30FD-0D60-4744-91A3-5C2B878E4757 Q24791835-135BF288-7C0C-47BB-BAFB-2D182ED6DBC1 Q24793831-84F61400-500F-45AF-A847-049D8FD4F890 Q24794430-BAF2232C-6B8A-4AB6-804B-63F7503A94E2 Q24802185-E31079E3-4C24-473C-94A1-4D00513CBEF8 Q24804835-97F62820-8EA7-4460-BC8B-001176E69398 Q24809319-C2696776-A285-4EAF-9FE7-586DF6B59836 Q24814716-A62E3190-01D0-4DBB-A267-61F6159DC55E Q25257267-B776F589-FF76-4C26-8F15-65D0712F87AF Q26782089-6F7926C9-7B4A-4D25-9154-45DDAAE9CD29 Q26786876-19913EF3-9FF9-423C-8BD2-27C30CBE2E5A Q26999252-0813BE24-82EE-4C09-8572-91AC3DE7044A Q27008193-CAF98EDA-622F-40ED-84CB-41DA501D4536 Q27683696-21F86876-9A70-4E98-9AB3-ABE6614B0085 Q28087657-0D1FD3C3-7845-4F22-A1A5-2A56FD5AB412 Q28262499-3435C340-A49F-4D36-A1F2-EDF07F815BEA Q29619021-BF308027-53B8-4EAB-914E-32FA11A12789 Q30311189-845E0136-37CF-418C-8841-41F96366DE2F Q30538460-29B79135-239D-4178-8D7F-52C80E2A7517 Q31146643-33FAB38D-790D-4E80-8AEB-82038A6AFFA9 Q33243420-6C9EE551-602E-490A-BCAF-C6E99C6962E4 Q33257088-5AA5C1D4-F488-41FD-9525-0717F791DF34 Q33286950-42462F37-9247-4626-A3CF-1D10123C765D Q33308712-8E930D01-0299-423E-9EBB-CF1CC5E98692 Q33329034-0AA0C833-17A5-45DD-9F04-32BF4EE0A4A6 Q33416000-CDB29801-2975-4318-A844-B056C88A2DB3 Q33503250-DC727C3F-BCBC-4AD1-BEE1-F3E9471D1BA1 Q33572902-E39B622A-105E-4B6D-B9FE-7C005F234994 Q33786171-27AECEDA-99E7-475C-AAEE-5AB0F20EA656 Q33925270-69C72FDF-90FF-4A4D-9CFA-91FA6C53CEA4 Q34080079-32496596-6519-4677-A31E-42A52ED623FE Q34103204-9F69AA21-716D-4C6B-B4F5-28888610E785 Q34172575-13081B8F-DB23-4A8A-8312-F55150E36ACD Q34252830-78035039-D862-4D7E-8E66-02C9D46F7FDA Q34360881-363698FD-8836-4943-AFAA-706F246308E5 Q34511095-677B5AC9-9672-4FFC-B778-BCE2E5F5E5E5 Q34517922-AD9CF892-1DA8-4A4F-93E9-1E0C0064CD9F Q34609180-A634629E-038D-46E2-A31C-F0CDF5B41181

P2860

Tolerance for mutations and chemical modifications in a siRNA.

http://www.wikidata.org/entity/Q39698017

description

2003 nî lūn-bûn

@nan

2003年の論文

@ja

2003年学术文章

@wuu

2003年学术文章

@zh-cn

2003年学术文章

@zh-hans

2003年学术文章

@zh-my

2003年学术文章

@zh-sg

2003年學術文章

@yue

2003年學術文章

@zh

2003年學術文章

@zh-hant

name

Tolerance for mutations and chemical modifications in a siRNA.

@en

Tolerance for mutations and chemical modifications in a siRNA.

@nl

type

label

Tolerance for mutations and chemical modifications in a siRNA.

@en

Tolerance for mutations and chemical modifications in a siRNA.

@nl

prefLabel

Tolerance for mutations and chemical modifications in a siRNA.

@en

Tolerance for mutations and chemical modifications in a siRNA.

@nl

P1433

Q39698017-9EE25FBD-6FCF-44B3-BCAF-0B6CC10B5100

P1476

Q39698017-5A7E2B43-F4C7-4322-BEB7-5859440A049E

P2093

Q39698017-60EE7A57-D539-487A-8DBE-95F8D8EF7FC7

Q39698017-9993B94B-07FA-4EB4-9530-BCC53A79B822

Q39698017-B1175482-5C92-41C5-8BF2-BBD8BF686784

Q39698017-E028F92C-C9CE-43C9-A128-D4194805C765

P2860

Q39698017-003EC130-238D-4A01-9612-6C4FCDAF8E1C

Q39698017-0A485F44-FB6B-497B-A8F9-75275AD94A42

Q39698017-0D00BD37-1725-4C6C-B74D-E48133409371

Q39698017-13819429-80C8-4161-895C-8432FC0062B1

Q39698017-2810BEA1-3F9D-47A3-9B31-7B23B750EF04

Q39698017-2A90723A-1147-4B11-8BD9-5055BCCF092B

Q39698017-2AF0D068-14E8-47A3-9948-E7A0C102E466

Q39698017-2B53B3FC-810D-4946-B022-6B9AE1AD59D7

Q39698017-347EACB0-F740-4B4A-BD12-6FC49FDE03E4

Q39698017-37E9D1C8-F06F-4F2F-B4A0-A0682F47F906

P304

Q39698017-4C69C84B-6DAE-44E9-A7FC-DFB912310AF0

P31

Q39698017-4A61376E-FD82-4D3B-A68D-DB517733493F

P356

Q39698017-71AC1138-7595-4BC7-9B87-5ECB22995FE6

P407

Q39698017-C4D7C324-15CF-40E8-96E3-FC06A6E117F6

P433

Q39698017-9FC3BD7C-EF5D-4C1C-A9B9-806C75ED0330

P478

Q39698017-CE5FA963-77DF-44C4-ABEA-EA20850532CF

P577

Q39698017-55564AA9-1018-4DBF-B785-30C0EA9C7468

P698

Q39698017-6EA5886A-6EF7-4FED-A0FD-63DAE556B8CF

P932

Q39698017-DC2784A7-7E6B-41FF-8B38-14F72F05BE4D

P356

P1433

Nucleic Acids Research

P1476

Tolerance for mutations and chemical modifications in a siRNA.

@en

P2093

Eshrat Babaie

http://www.w3.org/2001/XMLSchema#string

Hans Prydz

http://www.w3.org/2001/XMLSchema#string

Mohammed Amarzguioui

http://www.w3.org/2001/XMLSchema#string

Torgeir Holen

http://www.w3.org/2001/XMLSchema#string

P2860

Tsg101 and the vacuolar protein sorting pathway are essential for HIV-1 budding

Secondary structure prediction and in vitro accessibility of mRNA as tools in the selection of target sites for ribozymes

Human Dicer preferentially cleaves dsRNAs at their termini without a requirement for ATP

RNA interference is mediated by 21- and 22-nucleotide RNAs

A cellular function for the RNA-interference enzyme Dicer in the maturation of the let-7 small temporal RNA

Role for a bidentate ribonuclease in the initiation step of RNA interference

The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14

Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans

A system for stable expression of short interfering RNAs in mammalian cells

Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells

P304

589-595

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1093/NAR/GKG147

http://www.w3.org/2001/XMLSchema#string

P407

P433

2

http://www.w3.org/2001/XMLSchema#string

P478

31

http://www.w3.org/2001/XMLSchema#string

P577

2003-01-01T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P698

12527766

http://www.w3.org/2001/XMLSchema#string

P932

140512

http://www.w3.org/2001/XMLSchema#string