Tolerance for mutations and chemical modifications in a siRNA.
about
Designing of highly effective complementary and mismatch siRNAs for silencing a geneSmall interfering RNAs containing full 2'-O-methylribonucleotide-modified sense strands display Argonaute2/eIF2C2-dependent activity.Light-dependent RNA interference with nucleobase-caged siRNAssiRNA target site secondary structure predictions using local stable substructuresTowards in vivo application of RNA interference - new toys, old problemsLocked nucleic acid (LNA) mediated improvements in siRNA stability and functionalityHIV-1 can escape from RNA interference by evolving an alternative structure in its RNA genomeA systematic analysis of the silencing effects of an active siRNA at all single-nucleotide mismatched target sitesA rapid and sensitive assay for quantification of siRNA efficiency and specificityTolerated wobble mutations in siRNAs decrease specificity, but can enhance activity in vivo.Improvements in siRNA properties mediated by 2'-deoxy-2'-fluoro-beta-D-arabinonucleic acid (FANA)Therapeutic Oligonucleotides Targeting Liver Disease: TTR AmyloidosissiRNA Versus miRNA as Therapeutics for Gene SilencingRNA mediated Toll-like receptor stimulation in health and diseaseArgonaute-dependent small RNAs derived from single-stranded, non-structured precursorsAmides are excellent mimics of phosphate internucleoside linkages and are well tolerated in short interfering RNAsTechnologies for controlled, local delivery of siRNAStructural basis for overhang-specific small interfering RNA recognition by the PAZ domainA combined computational-experimental approach predicts human microRNA targetsSmall RNAs with imperfect match to endogenous mRNA repress translation. Implications for off-target activity of small inhibitory RNA in mammalian cells.Sniffing for gene-silencing efficiency of siRNAs in HeLa cells in comparison with that in HEK293T cells: correlation between knockdown efficiency and sustainability of sirnas revealed by FRET-based probingA universal plasmid library encoding all permutations of small interfering RNA.Short interfering RNA (siRNA) as a novel therapeutic.Designing siRNA that distinguish between genes that differ by a single nucleotideImproving model predictions for RNA interference activities that use support vector machine regression by combining and filtering features.Chemical modification: the key to clinical application of RNA interference?Analysis of siRNA specificity on targets with double-nucleotide mismatchesRNA modulators of complex phenotypes in mammalian cells.Inhibitors of MyD88-dependent proinflammatory cytokine production identified utilizing a novel RNA interference screening approachEffects of chemical modification on the potency, serum stability, and immunostimulatory properties of short shRNAs.High-density lipoproteins for the systemic delivery of short interfering RNA.siRNA-like double-stranded RNAs are specifically protected against degradation in human cell extract.Effect of chemical modifications on modulation of gene expression by duplex antigene RNAs that are complementary to non-coding transcripts at gene promoters.Improved siRNA/shRNA functionality by mismatched duplex.Global analysis of the mammalian RNA degradome reveals widespread miRNA-dependent and miRNA-independent endonucleolytic cleavage.Optimizations of siRNA design for the activation of gene transcription by targeting the TATA-box motif.siRNA therapeutics: big potential from small RNAs.siRNAmod: A database of experimentally validated chemically modified siRNAsSiRNA sequence model: redesign algorithm based on available genome-wide libraries.A role for human Dicer in pre-RISC loading of siRNAs.
P2860
Q21560930-B97140E2-ED7A-4AAA-9B8A-DE3B828FE8E9Q24537508-366B4DF5-4364-472D-9CEC-3BDA72E89594Q24676555-F29A30FD-0D60-4744-91A3-5C2B878E4757Q24791835-135BF288-7C0C-47BB-BAFB-2D182ED6DBC1Q24793831-84F61400-500F-45AF-A847-049D8FD4F890Q24794430-BAF2232C-6B8A-4AB6-804B-63F7503A94E2Q24802185-E31079E3-4C24-473C-94A1-4D00513CBEF8Q24804835-97F62820-8EA7-4460-BC8B-001176E69398Q24809319-C2696776-A285-4EAF-9FE7-586DF6B59836Q24814716-A62E3190-01D0-4DBB-A267-61F6159DC55EQ25257267-B776F589-FF76-4C26-8F15-65D0712F87AFQ26782089-6F7926C9-7B4A-4D25-9154-45DDAAE9CD29Q26786876-19913EF3-9FF9-423C-8BD2-27C30CBE2E5AQ26999252-0813BE24-82EE-4C09-8572-91AC3DE7044AQ27008193-CAF98EDA-622F-40ED-84CB-41DA501D4536Q27683696-21F86876-9A70-4E98-9AB3-ABE6614B0085Q28087657-0D1FD3C3-7845-4F22-A1A5-2A56FD5AB412Q28262499-3435C340-A49F-4D36-A1F2-EDF07F815BEAQ29619021-BF308027-53B8-4EAB-914E-32FA11A12789Q30311189-845E0136-37CF-418C-8841-41F96366DE2FQ30538460-29B79135-239D-4178-8D7F-52C80E2A7517Q31146643-33FAB38D-790D-4E80-8AEB-82038A6AFFA9Q33243420-6C9EE551-602E-490A-BCAF-C6E99C6962E4Q33257088-5AA5C1D4-F488-41FD-9525-0717F791DF34Q33286950-42462F37-9247-4626-A3CF-1D10123C765DQ33308712-8E930D01-0299-423E-9EBB-CF1CC5E98692Q33329034-0AA0C833-17A5-45DD-9F04-32BF4EE0A4A6Q33416000-CDB29801-2975-4318-A844-B056C88A2DB3Q33503250-DC727C3F-BCBC-4AD1-BEE1-F3E9471D1BA1Q33572902-E39B622A-105E-4B6D-B9FE-7C005F234994Q33786171-27AECEDA-99E7-475C-AAEE-5AB0F20EA656Q33925270-69C72FDF-90FF-4A4D-9CFA-91FA6C53CEA4Q34080079-32496596-6519-4677-A31E-42A52ED623FEQ34103204-9F69AA21-716D-4C6B-B4F5-28888610E785Q34172575-13081B8F-DB23-4A8A-8312-F55150E36ACDQ34252830-78035039-D862-4D7E-8E66-02C9D46F7FDAQ34360881-363698FD-8836-4943-AFAA-706F246308E5Q34511095-677B5AC9-9672-4FFC-B778-BCE2E5F5E5E5Q34517922-AD9CF892-1DA8-4A4F-93E9-1E0C0064CD9FQ34609180-A634629E-038D-46E2-A31C-F0CDF5B41181
P2860
Tolerance for mutations and chemical modifications in a siRNA.
description
2003 nî lūn-bûn
@nan
2003年の論文
@ja
2003年学术文章
@wuu
2003年学术文章
@zh-cn
2003年学术文章
@zh-hans
2003年学术文章
@zh-my
2003年学术文章
@zh-sg
2003年學術文章
@yue
2003年學術文章
@zh
2003年學術文章
@zh-hant
name
Tolerance for mutations and chemical modifications in a siRNA.
@en
Tolerance for mutations and chemical modifications in a siRNA.
@nl
type
label
Tolerance for mutations and chemical modifications in a siRNA.
@en
Tolerance for mutations and chemical modifications in a siRNA.
@nl
prefLabel
Tolerance for mutations and chemical modifications in a siRNA.
@en
Tolerance for mutations and chemical modifications in a siRNA.
@nl
P2093
P2860
P356
P1476
Tolerance for mutations and chemical modifications in a siRNA.
@en
P2093
Eshrat Babaie
Hans Prydz
Mohammed Amarzguioui
Torgeir Holen
P2860
P304
P356
10.1093/NAR/GKG147
P407
P577
2003-01-01T00:00:00Z