Effects of chemical modification on the potency, serum stability, and immunostimulatory properties of short shRNAs.
about
Progress toward in vivo use of siRNAs-IIMinimal-length short hairpin RNAs: the relationship of structure and RNAi activityMinimal-length Synthetic shRNAs Formulated with Lipid Nanoparticles are Potent Inhibitors of Hepatitis C Virus IRES-linked Gene Expression in MiceProtection of HIV neutralizing aptamers against rectal and vaginal nucleases: implications for RNA-based therapeutics.8-Oxoguanosine switches modulate the activity of alkylated siRNAs by controlling steric effects in the major versus minor grooves.Formulated minimal-length synthetic small hairpin RNAs are potent inhibitors of hepatitis C virus in mice with humanized livers.Transcription yield of fully 2'-modified RNA can be increased by the addition of thermostabilizing mutations to T7 RNA polymerase mutants.Development of Therapeutic-Grade Small Interfering RNAs by Chemical Engineering.Ribozyme-enhanced single-stranded Ago2-processed interfering RNA triggers efficient gene silencing with fewer off-target effectsDevelopment of a 2',4'-BNA/LNA-based siRNA for Dyslipidemia and Assessment of the Effects of Its Chemical Modifications In VivoRight- and left-loop short shRNAs have distinct and unusual mechanisms of gene silencingEmbedding siRNA sequences targeting apolipoprotein B100 in shRNA and miRNA scaffolds results in differential processing and in vivo efficacyTuning response curves for synthetic biology.Inhibition of hepatitis C virus in chimeric mice by short synthetic hairpin RNAs: sequence analysis of surviving virus shows added selective pressure of combination therapy.Subcellular fate and off-target effects of siRNA, shRNA, and miRNA.Lentiviral vector-mediated RNA silencing in the central nervous system.Current progress on aptamer-targeted oligonucleotide therapeutics.An intracellular buildup reaction of active siRNA species from short RNA fragments.Efficient delivery of RNA interference oligonucleotides to polarized airway epithelia in vitroMolecular Properties, Functional Mechanisms, and Applications of Sliced siRNA.Induction of RNAi Responses by Short Left-Handed Hairpin RNAi Triggers.Minimal 2'-O-methyl phosphorothioate linkage modification pattern of synthetic guide RNAs for increased stability and efficient CRISPR-Cas9 gene editing avoiding cellular toxicity.Chemical Modification of the siRNA Seed Region Suppresses Off-Target Effects by Steric Hindrance to Base-Pairing with Targets.Transforming growth factor β1 (TGFβ1) regulates CD44V6 expression and activity through extracellular signal-regulated kinase (ERK)-induced EGR1 in pulmonary fibrogenic fibroblasts.
P2860
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P2860
Effects of chemical modification on the potency, serum stability, and immunostimulatory properties of short shRNAs.
description
2009 nî lūn-bûn
@nan
2009 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
Effects of chemical modificati ...... ry properties of short shRNAs.
@ast
Effects of chemical modificati ...... ry properties of short shRNAs.
@en
Effects of chemical modificati ...... ry properties of short shRNAs.
@nl
type
label
Effects of chemical modificati ...... ry properties of short shRNAs.
@ast
Effects of chemical modificati ...... ry properties of short shRNAs.
@en
Effects of chemical modificati ...... ry properties of short shRNAs.
@nl
prefLabel
Effects of chemical modificati ...... ry properties of short shRNAs.
@ast
Effects of chemical modificati ...... ry properties of short shRNAs.
@en
Effects of chemical modificati ...... ry properties of short shRNAs.
@nl
P2093
P2860
P356
P1433
P1476
Effects of chemical modificati ...... ry properties of short shRNAs.
@en
P2093
Anne Dallas
Heini Ilves
Joshua Shorenstein
P2860
P304
P356
10.1261/RNA.1901810
P407
P577
2009-11-30T00:00:00Z