HTS-Compatible Patient-Derived Cell-Based Assay to Identify Small Molecule Modulators of Aberrant Splicing in Myotonic Dystrophy Type 1.
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Studying a Drug-like, RNA-Focused Small Molecule Library Identifies Compounds That Inhibit RNA Toxicity in Myotonic DystrophyDevelopment of an AP-FRET based analysis for characterizing RNA-protein interactions in myotonic dystrophy (DM1)Lomofungin and dilomofungin: inhibitors of MBNL1-CUG RNA binding with distinct cellular effects.Myoblasts generated by lentiviral mediated MyoD transduction of myotonic dystrophy type 1 (DM1) fibroblasts can be used for assays of therapeutic molecules.High-content screening identifies small molecules that remove nuclear foci, affect MBNL distribution and CELF1 protein levels via a PKC-independent pathway in myotonic dystrophy cell lines.Development of a Drosophila melanogaster spliceosensor system for in vivo high-throughput screening in myotonic dystrophy type 1.Cells of Matter-In Vitro Models for Myotonic Dystrophy.
P2860
Q28830592-97D4625B-B58E-4506-AA20-DD31084511F4Q30413238-C8CA7D89-B030-4316-AF5E-B0861AE42D8DQ33698593-8BEBD5E5-DAB1-48A8-BAA6-322B0156A919Q34073069-AF84AA63-A8C3-478B-A4FE-46084F202919Q35030106-8B083562-D448-477D-9D23-379ABDAEE3D2Q41997886-C9B68275-4960-4C83-93D0-A32AD51C76A4Q55100992-1D4E0A15-4852-49D2-A72F-9E74ED87F81C
P2860
HTS-Compatible Patient-Derived Cell-Based Assay to Identify Small Molecule Modulators of Aberrant Splicing in Myotonic Dystrophy Type 1.
description
2010 nî lūn-bûn
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name
HTS-Compatible Patient-Derived ...... in Myotonic Dystrophy Type 1.
@en
HTS-Compatible Patient-Derived ...... in Myotonic Dystrophy Type 1.
@nl
type
label
HTS-Compatible Patient-Derived ...... in Myotonic Dystrophy Type 1.
@en
HTS-Compatible Patient-Derived ...... in Myotonic Dystrophy Type 1.
@nl
prefLabel
HTS-Compatible Patient-Derived ...... in Myotonic Dystrophy Type 1.
@en
HTS-Compatible Patient-Derived ...... in Myotonic Dystrophy Type 1.
@nl
P2093
P2860
P1476
HTS-Compatible Patient-Derived ...... in Myotonic Dystrophy Type 1.
@en
P2093
Achim Brinker
Christian Schmedt
Debra A O'Leary
Ingo H Engels
Jeremy S Caldwell
Leonardo Vargas
Michael E Garcia
Orzala Sharif
Siu-Kei Chow
Yury J Sigal
P2860
P356
10.2174/1875397301004010009
P577
2010-03-19T00:00:00Z