Evidence for a TCR affinity threshold delimiting maximal CD8 T cell function. - Wikidata - wikimedia - TriplyDB

Evidence for a TCR affinity threshold delimiting maximal CD8 T cell function.

Evidence for a TCR affinity threshold delimiting maximal CD8 T cell function.

http://www.wikidata.org/entity/Q39721263

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TCR-Engineered T Cells Meet New Challenges to Treat Solid Tumors: Choice of Antigen, T Cell Fitness, and Sensitization of Tumor Milieu Identifying Individual T Cell Receptors of Optimal Avidity for Tumor Antigens Genetically modified T cells in cancer therapy: opportunities and challenges T-cell receptor gene therapy--ready to go viral?Smart CARs engineered for cancer immunotherapy Ecological analysis of antigen-specific CTL repertoires defines the relationship between naive and immune T-cell populations Polarized alloantigen presentation by airway epithelial cells contributes to direct CD8+ T cell activation in the airway.Identification of multiple public TCR repertoires in chronic beryllium disease.T cell therapy targeting a public neoantigen in microsatellite instable colon cancer reduces in vivo tumor growth.TCRep 3D: an automated in silico approach to study the structural properties of TCR repertoires.T cell avidity and tumor immunity: problems and solutions Profile of a serial killer: cellular and molecular approaches to study individual cytotoxic T-cells following therapeutic vaccination.Specific increase in potency via structure-based design of a TCR.Peptide-pulsed dendritic cells have superior ability to induce immune-mediated tissue destruction compared to peptide with adjuvant Specific roles of each TCR hemichain in generating functional chain-centric TCR.T cell receptor binding affinity governs the functional profile of cancer-specific CD8+ T cells Correlating RANK ligand/RANK binding kinetics with osteoclast formation and function Multiformat T-cell-engaging bispecific antibodies targeting human breast cancers.TCR affinity and specificity requirements for human regulatory T-cell function Chimeric antigen receptor-engineered T cells for the treatment of metastatic prostate cancer.Affinity-Tuned ErbB2 or EGFR Chimeric Antigen Receptor T Cells Exhibit an Increased Therapeutic Index against Tumors in Mice Interplay between T cell receptor binding kinetics and the level of cognate peptide presented by major histocompatibility complexes governs CD8+ T cell responsiveness.Molecular and Translational Classifications of DAMPs in Immunogenic Cell Death.Increased frequency of suppressive regulatory T cells and T cell-mediated antigen loss results in murine melanoma recurrence SHP-1 phosphatase activity counteracts increased T cell receptor affinity.CD4(+) and CD8(+) TCRβ repertoires possess different potentials to generate extraordinarily high-avidity T cells.T-cell receptor affinity and avidity defines antitumor response and autoimmunity in T-cell immunotherapy Enhanced-affinity murine T-cell receptors for tumor/self-antigens can be safe in gene therapy despite surpassing the threshold for thymic selection.Role of T cell receptor affinity in the efficacy and specificity of adoptive T cell therapies.Structure-Based, Rational Design of T Cell Receptors.MicroRNA-155 is required for effector CD8+ T cell responses to virus infection and cancer Architecture of a minimal signaling pathway explains the T-cell response to a 1 million-fold variation in antigen affinity and dose.Enhancement of tumor-reactive cytotoxic CD4+ T cell responses after ipilimumab treatment in four advanced melanoma patients.Transnuclear TRP1-specific CD8 T cells with high or low affinity TCRs show equivalent antitumor activity.Reproducible selection of high avidity CD8+ T-cell clones following secondary acute virus infection.2D TCR-pMHC-CD8 kinetics determines T-cell responses in a self-antigen-specific TCR system.Antigen-driven T-cell repertoire selection during adaptive immune responses.Structural and biophysical determinants of αβ T-cell antigen recognition.T-cell-receptor-like antibodies - generation, function and applications.Uncovering new aspects of protein interactions through analysis of specificity landscapes in peptide recognition domains.

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P2860

Evidence for a TCR affinity threshold delimiting maximal CD8 T cell function.

http://www.wikidata.org/entity/Q39721263

description

2010 nî lūn-bûn

@nan

2010年の論文

@ja

2010年論文

@yue

2010年論文

@zh-hant

2010年論文

@zh-hk

2010年論文

@zh-mo

2010年論文

@zh-tw

2010年论文

@wuu

2010年论文

@zh

2010年论文

@zh-cn

name

Evidence for a TCR affinity threshold delimiting maximal CD8 T cell function.

@en

Evidence for a TCR affinity threshold delimiting maximal CD8 T cell function.

@nl

type

label

Evidence for a TCR affinity threshold delimiting maximal CD8 T cell function.

@en

Evidence for a TCR affinity threshold delimiting maximal CD8 T cell function.

@nl

prefLabel

Evidence for a TCR affinity threshold delimiting maximal CD8 T cell function.

@en

Evidence for a TCR affinity threshold delimiting maximal CD8 T cell function.

@nl

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JIMMUNOL.1000173

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Journal of Immunology

P1476

Evidence for a TCR affinity threshold delimiting maximal CD8 T cell function

@en

P2093

Anita Posevitz-Fejfar

http://www.w3.org/2001/XMLSchema#string

Daniel E Speiser

http://www.w3.org/2001/XMLSchema#string

Daphné A Schmid

http://www.w3.org/2001/XMLSchema#string

J-C Floyd Sarria

http://www.w3.org/2001/XMLSchema#string

Melita B Irving

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Michael Hebeisen

http://www.w3.org/2001/XMLSchema#string

Nathalie Rufer

http://www.w3.org/2001/XMLSchema#string

Olivier Michielin

http://www.w3.org/2001/XMLSchema#string

Pedro Romero

http://www.w3.org/2001/XMLSchema#string

Raquel Gomez-Eerland

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4936-4946

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scholarly article

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10.4049/JIMMUNOL.1000173

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9

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184

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2010-03-29T00:00:00Z

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42639079

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20351194

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