CTLA-4 suppresses the pathogenicity of self antigen-specific T cells by cell-intrinsic and cell-extrinsic mechanisms.
about
Homeostasis and function of regulatory T cells (Tregs) in vivo: lessons from TCR-transgenic TregsA bispecific protein capable of engaging CTLA-4 and MHCII protects non-obese diabetic mice from autoimmune diabetesT-cell exhaustion in chronic hepatitis B infection: current knowledge and clinical significanceMurine regulatory T cells differ from conventional T cells in resisting the CTLA-4 reversal of TCR stop-signal.CD28 and ITK signals regulate autoreactive T cell trafficking.The role of co-inhibitory signals in spontaneous tolerance of weakly mismatched transplantsProtein kinase C-η controls CTLA-4-mediated regulatory T cell function.Foxo transcription factors control regulatory T cell development and functionFocused specificity of intestinal TH17 cells towards commensal bacterial antigens.[The role of co-inhibitory signals driven by CTLA-4 in immune system].T-cell regulation by casitas B-lineage lymphoma (Cblb) is a critical failsafe against autoimmune disease due to autoimmune regulator (Aire) deficiency.Immune inhibitory molecules LAG-3 and PD-1 synergistically regulate T-cell function to promote tumoral immune escapeA critical role for regulatory T cell-mediated control of inflammation in the absence of commensal microbiota.Inhibitory receptors are expressed by Trypanosoma cruzi-specific effector T cells and in hearts of subjects with chronic Chagas diseaseInduction of T cell anergy: integration of environmental cues and infectious tolerance.Opposing effects of CTLA4 insufficiency on regulatory versus conventional T cells in autoimmunity converge on effector memory in target tissue.Genetic susceptibility to autoimmune liver diseaseThe coinhibitory receptor CTLA-4 controls B cell responses by modulating T follicular helper, T follicular regulatory, and T regulatory cells.The soluble CTLA-4 splice variant protects from type 1 diabetes and potentiates regulatory T-cell functionPeripheral education of the immune system by colonic commensal microbiota.Higher proportions of circulating FOXP3+ and CTLA-4+ regulatory T cells are associated with lower fractions of memory CD4+ T cells in infants.Ligation of cytotoxic T lymphocyte antigen-4 to T cell receptor inhibits T cell activation and directs differentiation into Foxp3+ regulatory T cellsA transendocytosis model of CTLA-4 function predicts its suppressive behavior on regulatory T cells.Deletion of CTLA-4 on regulatory T cells during adulthood leads to resistance to autoimmunity.A broad range of self-reactivity drives thymic regulatory T cell selection to limit responses to self.From biomarkers to a clue of biology: a computation-aided perspective of immune gene expression profiles in human type 1 diabetes.Induction of autoimmune disease by deletion of CTLA-4 in mice in adulthood.Severe acute interstitial nephritis after combination immune-checkpoint inhibitor therapy for metastatic melanoma.Coinhibitory Pathways in the B7-CD28 Ligand-Receptor Family.Increased T regulatory cells lead to development of Th2 immune response in male SJL miceCD117+CD44+ Stem T Cells Develop in the Thymus and Potently Suppress T-cell Proliferation by Modulating the CTLA-4 Pathway.Tumor infiltrating regulatory T cells: tractable targets for immunotherapy.Regulatory T-cell differentiation versus clonal deletion of autoreactive thymocytes.Intrinsic and extrinsic control of peripheral T-cell tolerance by costimulatory molecules of the CD28/ B7 familyImmune checkpoints in central nervous system autoimmunity.Treg and CTLA-4: two intertwining pathways to immune tolerance.Understanding the CD28/CTLA-4 (CD152) pathway and its implications for costimulatory blockade.Diverse mechanisms regulate the surface expression of immunotherapeutic target ctla-4.Pharmacological Modulation of Proton Channel Hv1 in Cancer Therapy: Future Perspectives.Co-stimulate or Co-inhibit Regulatory T Cells, Which Side to Go?
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P2860
CTLA-4 suppresses the pathogenicity of self antigen-specific T cells by cell-intrinsic and cell-extrinsic mechanisms.
description
2009 nî lūn-bûn
@nan
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
2009年论文
@zh
2009年论文
@zh-cn
name
CTLA-4 suppresses the pathogen ...... and cell-extrinsic mechanisms.
@en
CTLA-4 suppresses the pathogen ...... and cell-extrinsic mechanisms.
@nl
type
label
CTLA-4 suppresses the pathogen ...... and cell-extrinsic mechanisms.
@en
CTLA-4 suppresses the pathogen ...... and cell-extrinsic mechanisms.
@nl
prefLabel
CTLA-4 suppresses the pathogen ...... and cell-extrinsic mechanisms.
@en
CTLA-4 suppresses the pathogen ...... and cell-extrinsic mechanisms.
@nl
P2093
P2860
P356
P1433
P1476
CTLA-4 suppresses the pathogen ...... and cell-extrinsic mechanisms.
@en
P2093
Anish Suri
Hyang Mi Lee
Katherine M Nutsch
Kenneth M Murphy
Masako Kohyama
Theresa L Murphy
Wataru Ise
P2860
P2888
P304
P356
10.1038/NI.1835
P407
P577
2009-12-27T00:00:00Z
P5875
P6179
1021874855