Discovery of Brain-Penetrant, Irreversible Kynurenine Aminotransferase II Inhibitors for Schizophrenia.
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Kynurenine Aminotransferase Isozyme Inhibitors: A ReviewBioactive heterocycles containing endocyclic N-hydroxy groupsCrystal structures of Mycobacterium tuberculosis HspAT and ArAT reveal structural basis of their distinct substrate specificities.Structural Basis for Substrate Specificity in ArnB. A Key Enzyme in the Polymyxin Resistance Pathway of Gram-Negative BacteriaStructure-Based Design of Irreversible Human KAT II Inhibitors: Discovery of New Potency-Enhancing InteractionsImportance of purity evaluation and the potential of quantitative ¹H NMR as a purity assay.The kynurenine pathway as a therapeutic target in cognitive and neurodegenerative disorders.Synthesis of 2',3',4'-trihydroxyflavone (2-D08), an inhibitor of protein sumoylationLysine-Targeting Covalent Inhibitors.Elevated kynurenine pathway metabolism during neurodevelopment: Implications for brain and behavior.Major developments in the design of inhibitors along the kynurenine pathway.The kynurenine pathway and the brain: Challenges, controversies and promises.Inhibitors of the kynurenine pathway as neurotherapeutics: a patent review (2012-2015).Abnormal kynurenine pathway of tryptophan catabolism in cardiovascular diseases.Ligand-enabled β-C-H arylation of α-amino acids using a simple and practical auxiliary.Amino acids inhibit kynurenic acid formation via suppression of kynurenine uptake or kynurenic acid synthesis in rat brain in vitro.Inhibition of human kynurenine aminotransferase isozymes by estrogen and its derivatives.Inhibition of Large Neutral Amino Acid Transporters Suppresses Kynurenic Acid Production Via Inhibition of Kynurenine Uptake in Rodent Brain.High resolution crystal structures of human kynurenine aminotransferase-I bound to PLP cofactor, and in complex with aminooxyacetate.Study of the Activity and Possible Mechanism of Action of a Reversible Inhibitor of Recombinant Human KAT-2: A Promising Lead in Neurodegenerative and Cognitive Disorders.Catalytic substitution/cyclization sequences of O-substituted Isocyanates: synthesis of 1-alkoxybenzimidazolones and 1-alkoxy-3,4-dihydroquinazolin-2(1H)-ones.Improvement of kynurenine aminotransferase-II inhibitors guided by mimicking sulfate esters.
P2860
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P2860
Discovery of Brain-Penetrant, Irreversible Kynurenine Aminotransferase II Inhibitors for Schizophrenia.
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年学术文章
@wuu
2012年学术文章
@zh-cn
2012年学术文章
@zh-hans
2012年学术文章
@zh-my
2012年学术文章
@zh-sg
2012年學術文章
@yue
2012年學術文章
@zh
2012年學術文章
@zh-hant
name
Discovery of Brain-Penetrant, ...... Inhibitors for Schizophrenia.
@en
Discovery of Brain-Penetrant, ...... Inhibitors for Schizophrenia.
@nl
type
label
Discovery of Brain-Penetrant, ...... Inhibitors for Schizophrenia.
@en
Discovery of Brain-Penetrant, ...... Inhibitors for Schizophrenia.
@nl
prefLabel
Discovery of Brain-Penetrant, ...... Inhibitors for Schizophrenia.
@en
Discovery of Brain-Penetrant, ...... Inhibitors for Schizophrenia.
@nl
P2093
P2860
P356
P1476
Discovery of Brain-Penetrant, ...... I Inhibitors for Schizophrenia
@en
P2093
Amy B Dounay
Artem Evdokimov
Brian M Campbell
Bruce M Bechle
Christine A Strick
Edelweiss Evrard
James Valentine
Jamison B Tuttle
Ji-Young Kim
P2860
P304
P356
10.1021/ML200204M
P577
2012-01-25T00:00:00Z