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Importin alpha-regulated nucleation of microtubules by TPX2.

Importin alpha-regulated nucleation of microtubules by TPX2.

http://www.wikidata.org/entity/Q39756365

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Identification of a TPX2-like microtubule-associated protein in Drosophila Phosphorylation of RCC1 in mitosis is essential for producing a high RanGTP concentration on chromosomes and for spindle assembly in mammalian cells Building a spindle of the correct length in human cells requires the interaction between TPX2 and Aurora A GM130 Regulates Golgi-Derived Spindle Assembly by Activating TPX2 and Capturing Microtubules Spindle pole regulation by a discrete Eg5-interacting domain in TPX2 The mechanism of spindle assembly: functions of Ran and its target TPX2 "HURP on" we're off to the kinetochore!Ahead of the Curve: New Insights into Microtubule Dynamics The base of the cilium: roles for transition fibres and the transition zone in ciliary formation, maintenance and compartmentalization TPX2 phosphorylation maintains metaphase spindle length by regulating microtubule flux.Complementary activities of TPX2 and chTOG constitute an efficient importin-regulated microtubule nucleation module.An epigenetic regulator emerges as microtubule minus-end binding and stabilizing factor in mitosis.Novel Binding of the Mitotic Regulator TPX2 (Target Protein for Xenopus Kinesin-like Protein 2) to Importin-α Putting things in place for fertilization: discovering roles for importin proteins in cell fate and spermatogenesis Eukaryotic cells and their cell bodies: Cell Theory revised Ran is required before metaphase for spindle assembly and chromosome alignment and after metaphase for chromosome segregation and spindle midbody organization.Functional overlap of microtubule assembly factors in chromatin-promoted spindle assembly.Dynamic release of nuclear RanGTP triggers TPX2-dependent microtubule assembly during the apoptotic execution phase.Poleward transport of TPX2 in the mammalian mitotic spindle requires dynein, Eg5, and microtubule flux.Phosphorylation of β-Tubulin by the Down Syndrome Kinase, Minibrain/DYRK1a, Regulates Microtubule Dynamics and Dendrite Morphogenesis.Ran-dependent TPX2 activation promotes acentrosomal microtubule nucleation in neurons.Xenopus importin beta validates human importin beta as a cell cycle negative regulator Genome-wide microarray evidence that 8-cell human blastomeres over-express cell cycle drivers and under-express checkpoints.The elegans of spindle assembly.TPX2 levels modulate meiotic spindle size and architecture in Xenopus egg extracts.Branching microtubule nucleation in Xenopus egg extracts mediated by augmin and TPX2.Importin alpha/beta and Ran-GTP regulate XCTK2 microtubule binding through a bipartite nuclear localization signal.Regulation of interkinetic nuclear migration by cell cycle-coupled active and passive mechanisms in the developing brain.A novel strategy for targeted killing of tumor cells: Induction of multipolar acentrosomal mitotic spindles with a quinazolinone derivative mdivi-1.Karyopherin alpha2 is essential for rRNA transcription and protein synthesis in proliferative keratinocytes Phosphorylation of targeting protein for Xenopus kinesin-like protein 2 (TPX2) at threonine 72 in spindle assembly.Nucleocytoplasmic transport in the midzone membrane domain controls yeast mitotic spindle disassembly Nuclear retention of importin α coordinates cell fate through changes in gene expression.Specific Cooperation Between Imp-α2 and Imp-β/Ketel in Spindle Assembly During Drosophila Early Nuclear Divisions Emergent Properties of the Metaphase Spindle.TPX2 regulates neuronal morphology through kinesin-5 interaction.Conservation of inner nuclear membrane targeting sequences in mammalian Pom121 and yeast Heh2 membrane proteins.TPX2 is required for postmitotic nuclear assembly in cell-free Xenopus laevis egg extracts.Drosophila importin alpha1 performs paralog-specific functions essential for gametogenesis.Aurora A phosphorylates MCAK to control ran-dependent spindle bipolarity.

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Importin alpha-regulated nucleation of microtubules by TPX2.

http://www.wikidata.org/entity/Q39756365

description

2003 nî lūn-bûn

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2003年の論文

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2003年学术文章

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2003年学术文章

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2003年学术文章

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2003年学术文章

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2003年學術文章

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2003年學術文章

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2003年學術文章

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name

Importin alpha-regulated nucleation of microtubules by TPX2.

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Importin alpha-regulated nucleation of microtubules by TPX2.

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Importin alpha-regulated nucleation of microtubules by TPX2.

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type

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Importin alpha-regulated nucleation of microtubules by TPX2.

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Importin alpha-regulated nucleation of microtubules by TPX2.

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Importin alpha-regulated nucleation of microtubules by TPX2.

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prefLabel

Importin alpha-regulated nucleation of microtubules by TPX2.

@en

Importin alpha-regulated nucleation of microtubules by TPX2.

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Importin alpha-regulated nucleation of microtubules by TPX2.

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The EMBO Journal

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Importin alpha-regulated nucleation of microtubules by TPX2.

@en

P2093

Christoph A Schatz

http://www.w3.org/2001/XMLSchema#string

Eric Karsenti

http://www.w3.org/2001/XMLSchema#string

Oliver J Gruss

http://www.w3.org/2001/XMLSchema#string

Rachel Santarella

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P2860

Generation of GTP-bound Ran by RCC1 is required for chromatin-induced mitotic spindle formation

p100: a novel proliferation-associated nuclear protein specifically restricted to cell cycle phases S, G2, and M

RanGAP1 induces GTPase activity of nuclear Ras-related Ran

TPX2, A novel xenopus MAP involved in spindle pole organization

Cleavage of structural proteins during the assembly of the head of bacteriophage T4

PSORT: a program for detecting sorting signals in proteins and predicting their subcellular localization

Chromosome-induced microtubule assembly mediated by TPX2 is required for spindle formation in HeLa cells

Isolation of a protein that is essential for the first step of nuclear protein import

Ran GTPase cycle and importins alpha and beta are essential for spindle formation and nuclear envelope assembly in living Caenorhabditis elegans embryos.

Role of importin-beta in coupling Ran to downstream targets in microtubule assembly.

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2060-2070

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10.1093/EMBOJ/CDG195

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9

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22

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Iain William Mattaj

Andreas Hoenger

Rafael E Carazo-Salas

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2003-05-01T00:00:00Z

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10776960

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12727873

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156067

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