Deubiquitinase USP9X stabilizes MCL1 and promotes tumour cell survival.
about
Mutations in USP9X are associated with X-linked intellectual disability and disrupt neuronal cell migration and growthTaspase1 functions as a non-oncogene addiction protease that coordinates cancer cell proliferation and apoptosisDUBbing Cancer: Deubiquitylating Enzymes Involved in Epigenetics, DNA Damage and the Cell Cycle As Therapeutic TargetsDrugging the undruggables: exploring the ubiquitin system for drug developmentTargeting Cell Survival Proteins for Cancer Cell DeathCross Talk of Proteostasis and Mitostasis in Cellular Homeodynamics, Ageing, and DiseaseNovel strategies to target the ubiquitin proteasome system in multiple myelomaRole of Deubiquitinating Enzymes in DNA RepairRegulation of Bim in Health and DiseaseBcl-2 antagonists: a proof of concept for CLL therapyTargeting the Bcl-2 family for cancer therapyGenetically engineered mouse models of pancreatic adenocarcinomaTargeting Mcl-1 for the therapy of cancerLa FAM fatale: USP9X in development and diseaseCDK Inhibitors Roscovitine and CR8 Trigger Mcl-1 Down-Regulation and Apoptotic Cell Death in Neuroblastoma CellsThe ubiquitin system: a critical regulator of innate immunity and pathogen-host interactionsMitochondrial apoptosis and BH3 mimeticsInhibition of 19S proteasome-associated deubiquitinases by metal-containing compoundsTrial Watch: Proteasomal inhibitors for anticancer therapyThe deubiquitinase Usp27x stabilizes the BH3-only protein Bim and enhances apoptosisNaturally Occurring Isothiocyanates Exert Anticancer Effects by Inhibiting Deubiquitinating EnzymesThe AAA-ATPase p97 is essential for outer mitochondrial membrane protein turnoverThr 163 phosphorylation causes Mcl-1 stabilization when degradation is independent of the adjacent GSK3-targeted phosphodegron, promoting drug resistance in cancerSeizures are regulated by ubiquitin-specific peptidase 9 X-linked (USP9X), a de-ubiquitinaseLoss of Usp9x disrupts cortical architecture, hippocampal development and TGFβ-mediated axonogenesisKinase-Independent Small-Molecule Inhibition of JAK-STAT SignalingSynthesis and evaluation of derivatives of the proteasome deubiquitinase inhibitor b-AP15Usp12 stabilizes the T-cell receptor complex at the cell surface during signalingNoncanonical regulation of alkylation damage resistance by the OTUD4 deubiquitinase.Spindle poisons and cell fate: a tale of two pathways.USP9X regulates centrosome duplication and promotes breast carcinogenesis.Identification of a deubiquitinating enzyme as a novel AGS3-interacting proteinUSP9X expression correlates with tumor progression and poor prognosis in esophageal squamous cell carcinoma.WP1130 increases cisplatin sensitivity through inhibition of usp9x in estrogen receptor-negative breast cancer cells.USP9X deubiquitylating enzyme maintains RAPTOR protein levels, mTORC1 signalling and proliferation in neural progenitors.MicroRNA-26b inhibits epithelial-mesenchymal transition in hepatocellular carcinoma by targeting USP9X.An atlas of altered expression of deubiquitinating enzymes in human cancerProlyl hydroxylation by EglN2 destabilizes FOXO3a by blocking its interaction with the USP9x deubiquitinase.PDK1 regulates B cell differentiation and homeostasis.Mcl-1 ubiquitination: unique regulation of an essential survival protein.
P2860
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P2860
Deubiquitinase USP9X stabilizes MCL1 and promotes tumour cell survival.
description
2009 nî lūn-bûn
@nan
2009年の論文
@ja
2009年学术文章
@wuu
2009年学术文章
@zh-cn
2009年学术文章
@zh-hans
2009年学术文章
@zh-my
2009年学术文章
@zh-sg
2009年學術文章
@yue
2009年學術文章
@zh
2009年學術文章
@zh-hant
name
Deubiquitinase USP9X stabilizes MCL1 and promotes tumour cell survival.
@en
Deubiquitinase USP9X stabilizes MCL1 and promotes tumour cell survival.
@nl
type
label
Deubiquitinase USP9X stabilizes MCL1 and promotes tumour cell survival.
@en
Deubiquitinase USP9X stabilizes MCL1 and promotes tumour cell survival.
@nl
prefLabel
Deubiquitinase USP9X stabilizes MCL1 and promotes tumour cell survival.
@en
Deubiquitinase USP9X stabilizes MCL1 and promotes tumour cell survival.
@nl
P2093
P356
P1433
P1476
Deubiquitinase USP9X stabilizes MCL1 and promotes tumour cell survival.
@en
P2093
David C S Huang
David Dornan
Dorothy M French
Fernando Bazan
Heather Maecker
Jennie R Lill
Karen O'Rourke
Martin Schwickart
Ronald Ferrando
P2888
P304
P356
10.1038/NATURE08646
P407
P577
2009-12-20T00:00:00Z
P5875
P6179
1041625366