Resistance to arginine deiminase treatment in melanoma cells is associated with induced argininosuccinate synthetase expression involving c-Myc/HIF-1alpha/Sp4.
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Argininosuccinate synthase: at the center of arginine metabolismArginine deprivation therapy for malignant melanomaA transgenic approach to study argininosuccinate synthetase gene expression.Argininosuccinate synthase 1 is an intrinsic Akt repressor transactivated by p53The Combination of Arginine Deprivation and 5-Fluorouracil Improves Therapeutic Efficacy in Argininosuccinate Synthetase Negative Hepatocellular Carcinoma.Phase I/II study of pegylated arginine deiminase (ADI-PEG 20) in patients with advanced melanoma.Arginine starvation impairs mitochondrial respiratory function in ASS1-deficient breast cancer cells.Expression profile and down-regulation of argininosuccinate synthetase in hepatocellular carcinoma in a transgenic mouse modelDown-regulation of argininosuccinate synthetase is associated with cisplatin resistance in hepatocellular carcinoma cell lines: implications for PEGylated arginine deiminase combination therapy.Arginine deiminase PEG20 inhibits growth of small cell lung cancers lacking expression of argininosuccinate synthetaseSpecificity protein 1 (sp1) oscillation is involved in copper homeostasis maintenance by regulating human high-affinity copper transporter 1 expression.The relationship of thioredoxin-1 and cisplatin resistance: its impact on ROS and oxidative metabolism in lung cancer cells.Negative argininosuccinate synthetase expression in melanoma tumours may predict clinical benefit from arginine-depleting therapy with pegylated arginine deiminase.Promoter methylation of argininosuccinate synthetase-1 sensitises lymphomas to arginine deiminase treatment, autophagy and caspase-dependent apoptosis.Activation of Ras/PI3K/ERK pathway induces c-Myc stabilization to upregulate argininosuccinate synthetase, leading to arginine deiminase resistance in melanoma cells.Arginine deprivation by arginine deiminase of Streptococcus pyogenes controls primary glioblastoma growth in vitro and in vivo.Gas6/Axl is the sensor of arginine-auxotrophic response in targeted chemotherapy with arginine-depleting agents.BRAF inhibitor resistance enhances vulnerability to arginine deprivation in melanoma.TRAIL induces autophagic protein cleavage through caspase activation in melanoma cell lines under arginine deprivationRecombinant human arginase induced caspase-dependent apoptosis and autophagy in non-Hodgkin's lymphoma cellsArginine deiminase resistance in melanoma cells is associated with metabolic reprogramming, glucose dependence, and glutamine addiction.Co-application of canavanine and irradiation uncouples anticancer potential of arginine deprivation from citrulline availabilityCisplatin-induced synthetic lethality to arginine-starvation therapy by transcriptional suppression of ASS1 is regulated by DEC1, HIF-1α, and c-Myc transcription network and is independent of ASS1 promoter DNA methylation.Arginine deprivation, autophagy, apoptosis (AAA) for the treatment of melanoma.Targeted cellular metabolism for cancer chemotherapy with recombinant arginine-degrading enzymes.Targeting arginine-dependent cancers with arginine-degrading enzymes: opportunities and challenges.The role of arginine and the modified arginine deiminase enzyme ADI-PEG 20 in cancer therapy with special emphasis on Phase I/II clinical trials.Parallel Expression of Enzyme Inhibitors of CD8T Cell Activity in Tumor Microenvironments and Secretory Endometrium.Reconstitution of T Cell Proliferation under Arginine Limitation: Activated Human T Cells Take Up Citrulline via L-Type Amino Acid Transporter 1 and Use It to Regenerate Arginine after Induction of Argininosuccinate Synthase Expression.Arginine deiminase: recent advances in discovery, crystal structure, and protein engineering for improved properties as an anti-tumor drug.Hypoxia-induced nitric oxide production and tumour perfusion is inhibited by pegylated arginine deiminase (ADI-PEG20).Targeting Cancer Metabolism: Dietary and Pharmacologic Interventions.Selective Intracellular Delivery of Recombinant Arginine Deiminase (ADI) Using pH-Sensitive Cell Penetrating Peptides To Overcome ADI Resistance in Hypoxic Breast Cancer CellsArginine dependence of tumor cells: targeting a chink in cancer's armor.Pegylated arginine deiminase synergistically increases the cytotoxicity of gemcitabine in human pancreatic cancerArginine-Dual roles as an onconutrient and immunonutrient.Three-dimensional environment renders cancer cells profoundly less susceptible to a single amino acid starvation.Single amino acid arginine starvation efficiently sensitizes cancer cells to canavanine treatment and irradiation.Recombinant human arginase inhibits the in vitro and in vivo proliferation of human melanoma by inducing cell cycle arrest and apoptosis.Chromatin remodeling system p300-HDAC2-Sin3A is involved in Arginine Starvation-Induced HIF-1α Degradation at the ASS1 promoter for ASS1 Derepression.
P2860
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P2860
Resistance to arginine deiminase treatment in melanoma cells is associated with induced argininosuccinate synthetase expression involving c-Myc/HIF-1alpha/Sp4.
description
2009 nî lūn-bûn
@nan
2009年の論文
@ja
2009年学术文章
@wuu
2009年学术文章
@zh-cn
2009年学术文章
@zh-hans
2009年学术文章
@zh-my
2009年学术文章
@zh-sg
2009年學術文章
@yue
2009年學術文章
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2009年學術文章
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name
Resistance to arginine deimina ...... nvolving c-Myc/HIF-1alpha/Sp4.
@en
Resistance to arginine deimina ...... nvolving c-Myc/HIF-1alpha/Sp4.
@nl
type
label
Resistance to arginine deimina ...... nvolving c-Myc/HIF-1alpha/Sp4.
@en
Resistance to arginine deimina ...... nvolving c-Myc/HIF-1alpha/Sp4.
@nl
prefLabel
Resistance to arginine deimina ...... nvolving c-Myc/HIF-1alpha/Sp4.
@en
Resistance to arginine deimina ...... nvolving c-Myc/HIF-1alpha/Sp4.
@nl
P2093
P2860
P1476
Resistance to arginine deimina ...... nvolving c-Myc/HIF-1alpha/Sp4.
@en
P2093
Isamu Aiba
Macus Tien Kuo
Niramol Savaraj
Soo-yong Lee
Wen-Bin Tsai
P2860
P304
P356
10.1158/1535-7163.MCT-09-0794
P577
2009-12-01T00:00:00Z