JNJ-28312141, a novel orally active colony-stimulating factor-1 receptor/FMS-related receptor tyrosine kinase-3 receptor tyrosine kinase inhibitor with potential utility in solid tumors, bone metastases, and acute myeloid leukemia.
about
Cancer-Associated Myeloid Regulatory CellsThe interaction of anticancer therapies with tumor-associated macrophagesMacrophage plasticity and polarization: in vivo veritasLeukocyte complexity predicts breast cancer survival and functionally regulates response to chemotherapyTherapeutic effects of anti-CD115 monoclonal antibody in mouse cancer models through dual inhibition of tumor-associated macrophages and osteoclasts.Inhibition of CSF-1R supports T-cell mediated melanoma therapyTumor associated macrophages and neutrophils in tumor progression.CSF-1R inhibition alters macrophage polarization and blocks glioma progression.CSF1 receptor targeting in prostate cancer reverses macrophage-mediated resistance to androgen blockade therapy.MRI of tumor-associated macrophages with clinically applicable iron oxide nanoparticlesPleiotropic effects of extended blockade of CSF1R signaling in adult mice.CSF1R Protein Expression in Reactive Lymphoid Tissues and Lymphoma: Its Relevance in Classical Hodgkin Lymphoma.Donor and recipient cell surface colony stimulating factor-1 promote neointimal formation in transplant-associated arteriosclerosisPharmacological targeting of CSF1R inhibits microglial proliferation and prevents the progression of Alzheimer's-like pathology.Targeting myeloid-derived suppressor cells with colony stimulating factor-1 receptor blockade can reverse immune resistance to immunotherapy in indoleamine 2,3-dioxygenase-expressing tumorsAutocrine inhibition of the c-fms proto-oncogene reduces breast cancer bone metastasis assessed with in vivo dual-modality imagingTiming of CSF-1/CSF-1R signaling blockade is critical to improving responses to CTLA-4 based immunotherapy.Targeting the tumor microenvironment: from understanding pathways to effective clinical trials.Inhibition of the colony-stimulating-factor-1 receptor affects the resistance of lung cancer cells to cisplatinBench to bedside targeting of FLT3 in acute leukemia.Tumor-associated macrophages in breast cancer as potential biomarkers for new treatments and diagnostics.c-FMS inhibitors: a patent review.FMS-like tyrosine kinase 3 inhibitors: a patent review.FMS Kinase Inhibitors: Current Status and Future Prospects.Anti-tumour strategies aiming to target tumour-associated macrophages.Angiogenesis inhibitors in cancer therapy: mechanistic perspective on classification and treatment rationales.Immunosuppressive networks and checkpoints controlling antitumor immunity and their blockade in the development of cancer immunotherapeutics and vaccines.The Promise of Targeting Macrophages in Cancer Therapy.Biological role of granulocyte macrophage colony-stimulating factor (GM-CSF) and macrophage colony-stimulating factor (M-CSF) on cells of the myeloid lineage.Macrophage Polarization: Anti-Cancer Strategies to Target Tumor-Associated Macrophage in Breast Cancer.Tumour-associated macrophages as treatment targets in oncology.Tumor-Associated Macrophages as Target for Antitumor Therapy.Discovery of AC710, a Globally Selective Inhibitor of Platelet-Derived Growth Factor Receptor-Family Kinases.Solid Tumor Immunotherapy with T Cell Engager-Armed Oncolytic Viruses.Differential Ly6C Expression after Renal Ischemia-Reperfusion Identifies Unique Macrophage Populations.Electrochemotherapy is effective in the treatment of rat bone metastases.Dynamic stroma reorganization drives blood vessel dysmorphia during glioma growth.MRI monitoring of monocytes to detect immune stimulating treatment response in brain tumor.The role of macrophage phenotype in regulating the response to radiation therapy.In Vivo MR Imaging of Tumor-Associated Macrophages: The Next Frontier in Cancer Imaging.
P2860
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P2860
JNJ-28312141, a novel orally active colony-stimulating factor-1 receptor/FMS-related receptor tyrosine kinase-3 receptor tyrosine kinase inhibitor with potential utility in solid tumors, bone metastases, and acute myeloid leukemia.
description
2009 nî lūn-bûn
@nan
2009年の論文
@ja
2009年学术文章
@wuu
2009年学术文章
@zh-cn
2009年学术文章
@zh-hans
2009年学术文章
@zh-my
2009年学术文章
@zh-sg
2009年學術文章
@yue
2009年學術文章
@zh
2009年學術文章
@zh-hant
name
JNJ-28312141, a novel orally a ...... s, and acute myeloid leukemia.
@en
JNJ-28312141, a novel orally a ...... s, and acute myeloid leukemia.
@nl
type
label
JNJ-28312141, a novel orally a ...... s, and acute myeloid leukemia.
@en
JNJ-28312141, a novel orally a ...... s, and acute myeloid leukemia.
@nl
prefLabel
JNJ-28312141, a novel orally a ...... s, and acute myeloid leukemia.
@en
JNJ-28312141, a novel orally a ...... s, and acute myeloid leukemia.
@nl
P2093
P1476
JNJ-28312141, a novel orally a ...... es, and acute myeloid leukemia
@en
P2093
Bruce E Tomczuk
Carl Crysler
Carl L Manthey
Carl R Illig
Carol F Franks
Christian Baumann
Dana L Johnson
Danielle Lawrence
Edward J Yurkow
P304
P356
10.1158/1535-7163.MCT-09-0255
P577
2009-11-03T00:00:00Z