Mutation G827R in matriptase causing autosomal recessive ichthyosis with hypotrichosis yields an inactive protease.
about
Matriptase autoactivation is tightly regulated by the cellular chemical environmentsProteolysis-induced N-terminal ectodomain shedding of the integral membrane glycoprotein CUB domain-containing protein 1 (CDCP1) is accompanied by tyrosine phosphorylation of its C-terminal domain and recruitment of Src and PKCdelta.Matriptase protects against experimental colitis and promotes intestinal barrier recoveryProbing the interaction mechanism of small molecule inhibitors with matriptase based on molecular dynamics simulation and free energy calculations.Activity and inhibition of prostasin and matriptase on apical and basolateral surfaces of human airway epithelial cellsProstasin is required for matriptase activation in intestinal epithelial cells to regulate closure of the paracellular pathway.The cutting edge: membrane-anchored serine protease activities in the pericellular microenvironment.Membrane-anchored serine proteases in health and disease.Matriptase-deficient mice exhibit ichthyotic skin with a selective shift in skin microbiota.Matriptase regulates proliferation and early, but not terminal, differentiation of human keratinocytesThe Transmembrane Serine Protease HAT-like 4 Is Important for Epidermal Barrier Function to Prevent Body Fluid Loss.Cleavage of hepatocyte growth factor activator inhibitor-1 by membrane-type MMP-1 activates matriptase.The structural requirements of matriptase in its ectodomain release in polarized epithelial cells.Proteolytic processing of the serine protease matriptase-2: identification of the cleavage sites required for its autocatalytic release from the cell surface.Matriptase does not require hepatocyte growth factor activator inhibitor type-1 for activation in an epithelial cell expression model.Design and synthesis of potent, selective inhibitors of matriptase.Requirement of the activity of hepatocyte growth factor activator inhibitor type 1 for the extracellular appearance of a transmembrane serine protease matriptase in monkey kidney COS-1 cells.Involvement of the cytoplasmic juxtamembrane region of matriptase in its exclusive localization to the basolateral membrane domain of Madin-Darby canine kidney epithelial cells.Roles of CUB and LDL receptor class A domain repeats of a transmembrane serine protease matriptase in its zymogen activation.The type II transmembrane serine protease matriptase cleaves the amyloid precursor protein and reduces its processing to β amyloid.Transcriptome analysis reveals TMPRSS6 isoforms with distinct functionalities.HAI-2 stabilizes, inhibits and regulates SEA-cleavage-dependent secretory transport of matriptase.
P2860
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P2860
Mutation G827R in matriptase causing autosomal recessive ichthyosis with hypotrichosis yields an inactive protease.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
2008年论文
@zh
2008年论文
@zh-cn
name
Mutation G827R in matriptase c ...... s yields an inactive protease.
@en
Mutation G827R in matriptase c ...... s yields an inactive protease.
@nl
type
label
Mutation G827R in matriptase c ...... s yields an inactive protease.
@en
Mutation G827R in matriptase c ...... s yields an inactive protease.
@nl
prefLabel
Mutation G827R in matriptase c ...... s yields an inactive protease.
@en
Mutation G827R in matriptase c ...... s yields an inactive protease.
@nl
P2093
P2860
P356
P1476
Mutation G827R in matriptase c ...... is yields an inactive protease
@en
P2093
Antoine Désilets
François-Olivier McDuff
Guillaume Vandal
Pierre Lavigne
Richard Leduc
P2860
P304
10535-10542
P356
10.1074/JBC.M707012200
P407
P577
2008-02-08T00:00:00Z