p53-dependent inhibition of TrxR1 contributes to the tumor-specific induction of apoptosis by RITA.
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JNK-NQO1 axis drives TAp73-mediated tumor suppression upon oxidative and proteasomal stressKEAP1-dependent synthetic lethality induced by AKT and TXNRD1 inhibitors in lung cancerAlteration of thioredoxin reductase 1 levels in elucidating cancer etiology.Effect of 2-chloro-substitution of adenine moiety in mixed-ligand gold(I) triphenylphosphine complexes on anti-inflammatory activity: the discrepancy between the in vivo and in vitro models.Wild type p53 reactivation: from lab bench to clinic.The conserved Trp114 residue of thioredoxin reductase 1 has a redox sensor-like function triggering oligomerization and crosslinking upon oxidative stress related to cell deathCooperative effects of Akt-1 and Raf-1 on the induction of cellular senescence in doxorubicin or tamoxifen treated breast cancer cells.Recent progress in targeting cancer.Inhibition of glycolytic enzymes mediated by pharmacologically activated p53: targeting Warburg effect to fight cancer.Redox effects and cytotoxic profiles of MJ25 and auranofin towards malignant melanoma cells.Cyclin D1 rare variants in UK multiple adenoma and early-onset colorectal cancer patients.APR-246/PRIMA-1MET inhibits thioredoxin reductase 1 and converts the enzyme to a dedicated NADPH oxidaseROS-dependent activation of JNK converts p53 into an efficient inhibitor of oncogenes leading to robust apoptosis.Anticancer activity of metal complexes: involvement of redox processes.RITA can induce cell death in p53-defective cells independently of p53 function via activation of JNK/SAPK and p38.Pharmacological targeting of p53 through RITA is an effective antitumoral strategy for malignant pleural mesothelioma.Chk2 mediates RITA-induced apoptosisCRISPR-Cas9-based target validation for p53-reactivating model compounds.Pipoxolan inhibits proliferation of HL-60 human leukaemia cancer cells by arresting the cell cycle at the G0/G1 phase.Ruthenium polypyridyl complexes as inducer of ROS-mediated apoptosis in cancer cells by targeting thioredoxin reductase.
P2860
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P2860
p53-dependent inhibition of TrxR1 contributes to the tumor-specific induction of apoptosis by RITA.
description
2009 nî lūn-bûn
@nan
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
2009年论文
@zh
2009年论文
@zh-cn
name
p53-dependent inhibition of Tr ...... nduction of apoptosis by RITA.
@en
p53-dependent inhibition of Tr ...... nduction of apoptosis by RITA.
@nl
type
label
p53-dependent inhibition of Tr ...... nduction of apoptosis by RITA.
@en
p53-dependent inhibition of Tr ...... nduction of apoptosis by RITA.
@nl
prefLabel
p53-dependent inhibition of Tr ...... nduction of apoptosis by RITA.
@en
p53-dependent inhibition of Tr ...... nduction of apoptosis by RITA.
@nl
P2093
P356
P1433
P1476
p53-dependent inhibition of Tr ...... induction of apoptosis by RITA
@en
P2093
Elias S J Arnér
Elisabeth Hedström
Joanna Zawacka-Pankau
Sofi Eriksson
P304
P356
10.4161/CC.8.21.9977
P577
2009-11-01T00:00:00Z